Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease by Mattia Cocco (1697905)

“…The in vitro determination of reactivity, cytotoxicity, NLRP3 ATPase inhibition, and antipyroptotic properties allowed the selection of <b>11</b> (INF39), a nontoxic, irreversible NLRP3 inhibitor able to decrease interleukin-1β release from macrophages. …”

Characterization of the interaction between macrophages and TiO₂ NF by confocal microscopy. by Manfredi Allegri (2575936)

The phosphorylation sites we identified in both ULK1 and ATG13 are conserved between different isoforms. by Zhiyuan Li (205620)

Histological quantification of the OA lesions: OARSI histological global score. by Rodrick Montjean (400649)

Effect of MET treatment on breast cancer cell proliferation, viability, ratio of phosphorylated Akt-to-total Akt and MOs phagocytosis capacity. by Zoheir Dahmani (9568899)

Protein expression and specific activity of Glo-I in whole liver and specific activity of Glo-I in pHEP, pHSC and pLSEC in controls, early and advanced cirrhosis. by Marcus Hollenbach (376231)

Baseline characteristics (N = 108)^*. by Taijiro Wake (8735415)

Assessment of Acid Gas Adsorption Selectivities in MIL-125-NH₂ by Chunyi Li (67747)

“…It was hypothesized that the presence of H₂S resulted in a slight decrease in pore volume and weaker binding of condensable gases. …”

Model of VPA-induced inositol depletion via inhibition of Mck1. by Wenxi Yu (4373743)

“…Positive regulation of MIPS by Mck1 is inhibited by VPA, thus accounting for VPA-induced inhibition of MIPS and concomitant decrease in inositol synthesis. Inositol depletion causes a plethora of cellular consequences, including those that contribute to mood-stabilization.…”

Chronologic change in standardized liver volume from baseline to 24 and 48 weeks after treatment initiation. by Taijiro Wake (8735415)

Modulation of the IL-22- and IFN-γ-induced gene expression by DCE and CS. by Claudia Scarponi (205759)

Circular plot representing calves’ birth date distribution in relation to the reproduction, gestation and lactation periods expected for the species [35]. by Michelle Gelippi (9580022)

Effect of melatonin (50 μM) on the TGF-β1 (10 ng/mL, 72 h)-mediated TGF-β1/Smad pathway and EMT in HBdSMCs. by Yang Zhang (30734)

Skill acquisition as a function of age, hand and task difficulty: Interactions between cognition and action - Fig 1 by Rachael K. Raw (747045)

“…<p>Recall performance when iteratively using Eqs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0211706#pone.0211706.e001" target="_blank">1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0211706#pone.0211706.e002" target="_blank">2</a> to model storage of a sequence of movements in the correct order: (A) A smaller working memory capacity will decrease recall on any iteration and lengthen the time taken to learn the whole sequence; (B) A larger element size has a similar effect; (C) The combination of smaller elements and larger capacity will increase recall, whereas larger elements and smaller capacity will decrease recall; (D) A smaller capacity and/or larger element size will decrease the ‘chunk size’–the number of items within a unit written to the longer term storage system.…”

Panel A illustrates the percentage change of the sum of all target lesions expressed in TLG versus PFS in weeks. by Erik J. van Helden (2794642)

“…<p>All patients with clinical benefit have a > 45% decrease in TLG. Notably, there is a significant correlation between reduction in TLG and a longer PFS (R_s -0.94, p-value < 0.001). …”

The effects of ULK1-ATG13 sites at mTOR and AMPK on mitotic mobility shift. by Zhiyuan Li (205620)

Rates of IR and ER opioid analgesic endorsement, RADARS Survey of Key Informants’ Patients Program. by Janetta L. Iwanicki (3390572)

Rates of IR and ER opioid analgesic endorsement, RADARS Opioid Treatment Program. by Janetta L. Iwanicki (3390572)

Rates of IR and ER opioid analgesic diversion, RADARS Drug Diversion Program. by Janetta L. Iwanicki (3390572)

Directional Noncovalent Interactions: Repulsion and Dispersion by Ahmed El Kerdawy (1866172)

“…The potential-energy hypersurfaces show two types of minima: (1) collinear with the dihalogen bond and (2) in a bridging position. The former represent the most stable minima for these systems, and their binding energies decrease in the order Br > Cl > F. …”