Image 3_The N6-methyladenosine RNA epigenetic modification modulates the amplification of coxsackievirus B1 in human pancreatic beta cells.tif by Maressa Fernandes Bonfim (6700379)

“…Using small interfering RNA (siRNA) targeting m6A writers and erasers, we observed that downregulation of m6A writers increases CVB1 amplification, while the downregulation of m6A erasers decreases it. …”

Image 1_The N6-methyladenosine RNA epigenetic modification modulates the amplification of coxsackievirus B1 in human pancreatic beta cells.tif by Maressa Fernandes Bonfim (6700379)

“…Using small interfering RNA (siRNA) targeting m6A writers and erasers, we observed that downregulation of m6A writers increases CVB1 amplification, while the downregulation of m6A erasers decreases it. …”

Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27^Kip1 Upregulation by Sreelatha Gopinath (238422)

“…These effects could be mediated by αVβ3/PI3K/AKT/FOXO pathway as observed by the decreased αVβ3 expression, PI3K and AKT phosphorylation accompanied by elevated FOXO3a levels. …”

Image 4_The N6-methyladenosine RNA epigenetic modification modulates the amplification of coxsackievirus B1 in human pancreatic beta cells.tif by Maressa Fernandes Bonfim (6700379)

“…Using small interfering RNA (siRNA) targeting m6A writers and erasers, we observed that downregulation of m6A writers increases CVB1 amplification, while the downregulation of m6A erasers decreases it. …”

Significantly increased or decreased functions in the AY comparison. by Raihan K. Uddin (434686)

Decreased β1 integrin under hypoxia. by Nathalie E. Zeitouni (843137)

Probability of correct assignment with decreasing number of loci. by Caroline G. Storer (117550)

RA increases S100β+ and decreases peripherin+ cell prevalence while EDN3 decreases S100β+ cell prevalence. by Jonathan M. Gisser (456149)

“…(A) The proportion of S100β+ cells was enriched by RA and decreased in response to EDN3 (B) RA increased, and EDN3 decreased the fraction of proliferating S100β+ cells. …”

Cellular co-infection decreases the potential for superinfection. by Brigitte E. Martin (8366847)

Immunohistochemical staining for endothelial cells (CD146) and astrocytes (GFAP) in the lumbar spinal cord of G93A mice at early and late stages of disease. by Svitlana Garbuzova-Davis (81764)

“…In G93A mice at (D, E) early or (F, G) end-stage of disease, decreased CD146 antigen expression by endothelial cells (green, arrowheads) was observed. …”

Comparison of the two approaches in decreasing blood pressure. by Ze-qun Li (772836)

FASN inhibition decreased β-catenin expression. by Pascal Gelebart (174443)

“…<p>The MCL cell line Mino was treated with Orlistat (A) or siRNA (B) to inhibit or knock-down FASN, respectively. …”

Translation Elongation Factor 1A Facilitates the Assembly of the Tombusvirus Replicase and Stimulates Minus-Strand Synthesis by Zhenghe Li (238151)

“…Using a random library of eEF1A mutants, we identified one mutant that decreased and three mutants that increased <em>Tomato bushy stunt virus</em> (TBSV) replication in a yeast model host. …”

Data_Sheet_1_Two DsbA Proteins Are Important for Vibrio parahaemolyticus Pathogenesis.docx by Chun-qin Wu (6705872)

“…The protein levels of adhesion factor VpadF (VP1767) and the thermostable direct hemolysin (TDH) were significantly reduced in the dsbA deletion mutants. V. parahaemolyticus lacking dsbA also showed reduced attachment to Caco-2 cells, decreased β-hemolytic activity, and less toxicity to both zebrafish and HeLa cells. …”

Repression of let-7a and let-7b is dependent on ATM phosphorylation of p53. by Anthony D. Saleh (342299)

“…ATM^+/+ and ATM^−/− fibroblasts were also collected after irradiation and expression of let-7a (B) and let-7b (C) decreased in the ATM^+/+cells but not in ATM^−/− cells suggesting that ATM-dependent p53 activation is necessary for radiation-induced changes in let-7 expression.* denotes p<0.05.…”

PrioV3 and ICSM35 antibodies inhibit accumulation of PrP^Sc in ScN2a cells. by Daryl Rhys Jones (351314)

“…PrioV3 has also led to decreased levels of normal prion protein. ICSM35 led to a significant (P<0.001) reduction in prion replication compared to BRIC126-treated or untreated cells. …”

Ndel1 decreases oligomerization of Dyn2. by Mathieu Chansard (232234)

Decreased angiogenesis in DDAH1 KO mice. by Ping Zhang (86495)

Extended exposure to extracellular adenosine (ADO) causes a dose-dependent reduction in chlamydial development via the A2b adenosine receptor. by Matthew A. Pettengill (256020)

“…(<b>B</b>) HeLa cell knock-downs (KDs) were produced with non-targeted (Control), A2a-targeted (A2a KD) or A2b-targeted (A2b KD) shRNA and levels of target KD verified to be decreased at least 50% by qPCR. …”

Iron supplementation decreases severity of allergic asthma. by Laura P. Hale (148029)

“…<p>WT and mast cell-deficient <i>Sash</i> mice on the indicated diets were sensitized to OVA then challenged with OVA or saline. <b>A</b>. Airway resistance (measured in units of cm H₂O/ml/sec) in response to methacholine was significantly decreased following allergen challenge for mice that received iron supplementation (*indicates p≤0.0005). …”