Phosphate Diester Hydrolysis and DNA Damage Promoted by New <i>cis</i>-Aqua/Hydroxy Copper(II) Complexes Containing Tridentate Imidazole-rich Ligands by Marciela Scarpellini (2382364)

“…Complex <b>1</b> effectively promoted the hydrolytic cleavage of double-strand plasmid DNA under anaerobic and aerobic conditions, with a rate constant of 0.28 h^-1 for the decrease of form I, which represents about a 10⁷ rate increase compared with the estimated uncatalyzed rate of hydrolysis.…”

DataSheet1_Plasmodium Circumsporozoite Protein Enhances the Efficacy of Gefitinib in Lung Adenocarcinoma Cells by Inhibiting Autophagy via Proteasomal Degradation of LC3B.PDF by Xiao Lu (355468)

“…In the OE-CSP group, autophagy was significantly inhibited, and there was a decrease in LC3B protein after exposure to gefitinib. …”

Table_1_Circular RNA Expression Profiling Identifies Glaucoma-Related Circular RNAs in Various Chronic Ocular Hypertension Rat Models.XLS by Xiaoxiao Chen (1673935)

“…The expression of hsa_circ_0023826 showed a significant decrease in glaucoma patients, while TENM4 mRNA showed no significant difference compared to cataract patients (P = 0.024 and P = 0.294, respectively). …”

DataSheet_1_Cyclic adenosine monophosphate/phosphodiesterase 4 pathway associated with immune infiltration and PD-L1 expression in lung adenocarcinoma cells.zip by Ling Tong (632992)

“…In the cell experiment, forskolin (an adenylate cyclase activator) and zardaverine (a PDE4 inhibitor) enhance the cAMP pathway and decrease PD-L1 expression, while SQ2253 (an adenylate cyclase inhibitor) inhibits the cAMP pathway and increases PD-L1 expression of the LUAD cell lines H1299 and A549, and MYC regulation by these drugs was positively correlated with PD-L1 regulation, which verified the regulation of the cAMP/PDE4 pathway on MYC and PD-L1.…”

Data_Sheet_1_An automated heart rate-based algorithm for sleep stage classification: Validation using conventional polysomnography and an innovative wearable electrocardiogram devi... by Nicolò Pini (11370516)

“…AHI and biological sex did not affect scoring, while a significant decrease of performance by age was reported across the models. …”

The prevalence of depression and associated risk factors among medical students: An untold story in Vietnam by Tung Pham (6406841)

“…<div><p>Background</p><p>Depression is a common mental health problem in medical students worldwide. …”

Data_Sheet_1_An analysis of African Swine Fever consequences on rural economies and smallholder swine producers in Haiti.docx by Ralph P. Jean-Pierre (13945596)

“…The 2021 outbreaks in the Dominican Republic and Haiti pose threats to animal health, livestock markets, and producer livelihoods. A partial equilibrium Haitian pig sector model (HPM-2021) was developed to assess the economic impacts of a 2021 Haitian ASF outbreak of a similar size to the 1980s outbreak. …”

DataSheet_1_Omicron SARS-CoV-2 infection management and outcomes in patients with hematologic disease and recipients of cell therapy.docx by José Luis Piñana (12514534)

“…</p>Purpose<p>To assess the current clinical management and outcome of SARS-CoV-2 infection diagnosed, identify the risk factors for severe outcomes according to the HD characteristics and cell therapy procedures in a real-world setting.</p>Methods<p>A retrospective observational registry led by the Spanish Transplant Group (GETH-TC) with 692 consecutive patients with HD from December 2021 to May 2023 was analyzed.…”

MiR-499 Regulates Cell Proliferation and Apoptosis during Late-Stage Cardiac Differentiation via Sox6 and Cyclin D1 by Xianhui Li (457183)

“…MiR-499 knock-down enhanced apoptosis in the late differentiation stage in P19CL6 cells, but overexpression of miR-499 resulted in a decrease in the apoptosis rate. Sox6 was identified as a direct target of miR-499 and its expression was detected from day 8 or day 10 of cardiac differentiation of P19CL6 cells. …”

Table_4_Cyclic adenosine monophosphate/phosphodiesterase 4 pathway associated with immune infiltration and PD-L1 expression in lung adenocarcinoma cells.xlsx by Ling Tong (632992)

“…In the cell experiment, forskolin (an adenylate cyclase activator) and zardaverine (a PDE4 inhibitor) enhance the cAMP pathway and decrease PD-L1 expression, while SQ2253 (an adenylate cyclase inhibitor) inhibits the cAMP pathway and increases PD-L1 expression of the LUAD cell lines H1299 and A549, and MYC regulation by these drugs was positively correlated with PD-L1 regulation, which verified the regulation of the cAMP/PDE4 pathway on MYC and PD-L1.…”

DataSheet1_Uptake of selected organic ligands by hardened cement paste: Studies on proxy ligands for the degradation of polyacrylonitrile and general considerations on the role of... by P. G. Szabo (13908240)

“…On the contrary, GTA induces a clear decrease in the surface charge above [GTA]_tot ≈ 10⁻³ M resulting in an isoelectric point at [GTA]_tot ≈ 6⋅10⁻² M. …”

RE-AIM indicators. by Gadapani Barsha Pathak (20700684)

“…<div><p>Background</p><p>Stillbirth remains a public health concern in India, despite a decrease in reported rates. …”

Treatment with rFXIII ameliorates colitis severity in both WT and FXIII^−/− mice. by Christina Andersson (758618)

“…More significantly, DSS-challenged WT mice treated with rFXIII (H) exhibited generally intact, near-normal appearing mucosa. (I) A detailed microscopic evaluation of tissue sections from all FXIII^−/− mice employing the multiparameter histopathological scoring system showed that exogenous rFXIII treatment (white bars) resulted in a significant decrease in ulceration and crypt loss relative to vehicle treatment (black bars). …”

Image1_Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair.tiff by Kevin O. Rivera (15802457)

“…Hydrogel-based microparticle platforms may be a clinically relevant solution to create controlled and localized drug delivery to treat bone fractures. …”

The RA and FGF/MAPK pathways control the AP patterning of <i>Ciona</i> tail epidermis. by Andrea Pasini (17809)

“…(<b>Q–T</b>): Epidermal expression of a dominant-negative form of the <i>Ciona</i> FGF receptor leads to the ectopic expression of <i>Ci-hox1</i> (arrowhead in Q) and to the loss or decrease of <i>Ci-hox12</i> (R), <i>Ci-wnt5</i> (S) and <i>Ci-fgf8/17/18</i> (T). …”

Perspectives on research DTTC (Thomas et al., 2025) by Donna Thomas (12427672)

“…</p><p dir="ltr"><b>Conclusions: </b>Aspects of the research DTTC were uncomfortable for SLPs and families, despite its efficacy and what they learned from participating. SLPs perceived a schism between researchers and clinicians. More needs to be done to decrease the perceived gap between researchers and clinicians to facilitate implementation of evidence-based practice in nonresearch contexts.…”

miR-122 hybridizes to the 3′UTR of <i>Pkm2</i> and induces endogenous translation suppression. by Christine J. Jung (194986)

“…Renilla luciferase construct was used as a normalization tool. The bar graphs show a decrease in luciferase activity when the cells were cotransfected with the wild-type (WT#1 or WT#2) MREs and precursor miR-122 molecules compared to the mock control. …”

The Cost-Effectiveness of Intermittent Preventive Treatment for Malaria in Infants in Sub-Saharan Africa by Lesong Conteh (231114)

“…<div><h3>Background</h3><p>Intermittent preventive treatment in infants (IPTi) has been shown to decrease clinical malaria by approximately 30% in the first year of life and is a promising malaria control strategy for Sub-Saharan Africa which can be delivered alongside the Expanded Programme on Immunisation (EPI). …”

Feedback patterns of avian longitudinal-experimental immune responses against West Nile Virus. by Ariel L. Rivas (155906)

“…<p><b>A</b>: Leukocyte and microbial test results of 10 chickens (shown to be West Nile virus [WNV] negative at day 0) were inoculated with WNV and followed over two weeks (total: 82 longitudinal observations). …”

Task-rest correspondence: Composition of resting networks underlying psychological tasks. by Danilo Bzdok (333738)

“…This is exemplified by gender judgments and trustworthiness judgments on visually presented faces: Consistent with previously published experimental fMRI studies [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004994#pcbi.1004994.ref053" target="_blank">53</a>], the default-mode network (<i>black square</i>), implicated in higher-order social processing, exhibited significant increase with trustworthiness judgments but decrease with gender judgments on faces. …”