Clinical characterization and founder effect analysis in Chinese amyotrophic lateral sclerosis patients with <i>SOD1</i> common variants by Pei-Shan Wang (13030269)

“…The genotype–phenotype relationship of patients with <i>SOD1</i> p.H47R, p.V48A and p.C112Y patients were summarized.</p><p><i>SOD1^V48A</i> fibroblasts showed mutant SOD1 aggregate formation, enhanced intracellular reactive oxygen species level, and decreased mitochondrial membrane potential compared to the control fibroblast.…”

Image_1_Changes in the Leptin to Adiponectin Ratio Are Proportional to Weight Loss After Meal Replacement in Adults With Severe Obesity.pdf by Mohammed Faraz Rafey (12560062)

“…In patients with T2DM, HbA1c decreased from 60.0 ± 17.4 to 47.5 ± 15.5 mmol/mol (p < 0.001). …”

Table_1_Changes in the Leptin to Adiponectin Ratio Are Proportional to Weight Loss After Meal Replacement in Adults With Severe Obesity.docx by Mohammed Faraz Rafey (12560062)

“…In patients with T2DM, HbA1c decreased from 60.0 ± 17.4 to 47.5 ± 15.5 mmol/mol (p < 0.001). …”

Neuronal response to an external current. by Eduarda Susin (11442545)

“…<p>A: External drive fluctuation. External current, in each neuron, varied from 0 to 0.5 nA in a linear way, was kept constant for 500 ms, subsequently decreasing to 0 nA in a linear way. …”

Example of how traits and alleles interact in the vector genetics model. by Prashanth Selvaraj (5677121)

“…Male mosquitoes carrying the ‘a1’ allele in a homozygous or heterozygous configuration have decreased mortality, which is thus a dominant trait, and is modeled as a halving of their probability of dying. …”

The PI3K pathway mediates the function of CXCR4 in prostate tumor initiating population. by Anna Dubrovska (105746)

“…<p>(A) Isolated CXCR4⁺ PC3 cells showed decreased expression levels of FOXO3A responsive genes such as p21, GADD45, p130, BIM1, CyclinG2 compared to CXCR4⁻PC3 cells. mRNA levels were determined by quantitative RT-PCR and normalized to GAPDH mRNA. …”

Migration and Invasion Assay. by Ning Wang (108353)

“…The MCF10A/HtrA1 cell line over-expressing HtrA1 showed significantly decreased (p<0.01) migration vs. the control cell lines. …”

Summary of BAFF and BR3 mRNA expression by Q-PCR, BAFF, BR3, and TACI expression by FACS. by Jiahui Yang (255269)

“…This overview summarizes results of measurements of pre-immune (Pre) and post boost 3 (3^rd) BAFF and BR3 mRNA in total PBMC by Q-PCR [in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0008494#pone-0008494-t003" target="_blank">Table 3</a>, the unit number showing relative mRNA levels in each sample was determined as a value of mRNA normalized against peptidylprolyl isomerase A (PPIA)]. …”

DataSheet1_SNP–SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children.docx by Chintan K. Gandhi (7254926)

“…A decreased risk at 6 months was associated with an interaction among the same SNPs of SFTPB and SFTPD and the rs1136450 of SFTPA1. …”

Supplementary Material for: Bubble CPAP Support after Discontinuation of Mechanical Ventilation Protects Rat Lungs with Ventilator-Induced Lung Injury by Wu C.S. (3351785)

“…<b><i>Results:</i></b> The bubble technique (2.5 and 5.5 mm diameter combined) resulted in a significantly higher PaO₂, decreased alveolar protein levels (1.01 vs. 1.43 mg/kg, p < 0.05), a lower lung injury score (3.87 vs. 4.86, p < 0.05), and decreased NOS3 expression (1.99 vs. 3.32, p < 0.05) compared to spontaneous breathing in the control group. …”

S1 Appendix - Modelling Future Coronary Heart Disease Mortality to 2030 in the British Isles by John Hughes (650501)

“…Fig B. Predicted decreases in Deaths in 2030 based on ‘No mortality change’ between 2010 and 2030 for (A) IDEAL scenarios & (B) MODEST Scenarios. …”

Image_3_Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antit... by Loredana Bergandi (4170769)

“…Finally, hyperglycemia reduced cell death by decreasing the cell percentage in sub-G1 peak induced by DOX (via a cell cycle arrest in the G2/M phase) and 5-FU (via a cell cycle arrest in the S phase) in HT29 and LOVO cells. …”

Image_1_Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antit... by Loredana Bergandi (4170769)

“…Finally, hyperglycemia reduced cell death by decreasing the cell percentage in sub-G1 peak induced by DOX (via a cell cycle arrest in the G2/M phase) and 5-FU (via a cell cycle arrest in the S phase) in HT29 and LOVO cells. …”

<b><i>Differential impacts of asymmetric winter warming and symmetric year-round warming on leaf nutrient and resorption in an alpine meadow</i></b> by Huanhuan Song (12835471)

“…Here, we investigated the effects of long-term (10-yr) symmetric year-round warming and asymmetric winter warming on nitrogen (N) and phosphorus (P) resorption of four plant functional groups (13 common species from grasses, forbs, legumes and sedges) in a Tibetan alpine meadow.<b><i> </i></b>Across functional groups, year-round warming decreased green and senesced leaf N and P concentrations, and N resorption efficiency (NRE), while<a href="" target="_blank"> winter warming increased senesced leaf P concentration and decreased P resorption efficiency (PRE)</a>. …”

Effects of the homology between training and testing query datasets on the accuracy of secondary structure prediction. by Teng-Ruei Chen (9046518)

“…<p><b>(A)</b> The layout of datasets. The NR<i>x</i> indicates the non-redundancy of sequences in one or between two datasets, where <i>x</i> is the sequence identity cutoff. …”

Percentage change of clinical and QOL parameters throughout PEs in CF. by Gabriella Wojewodka (429774)

“…Other QOL domains which decreased at Day 1 include: Vitality, Health Perceptions, Social and Role (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088567#pone.0088567.s002" target="_blank">Table S1</a>). …”

Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of <i>C</i>. <i>albicans</i> Virulence Pathways by Nora Grahl (194196)

“…The Ras1 GTPase activating protein, Ira2, but not the Ras1 guanine nucleotide exchange factor, Cdc25, was required for the reduction of Ras1-GTP in response to inhibitor-mediated reduction of ATP levels. Furthermore, Cyr1, a well-characterized Ras1 effector, participated in the control of Ras1-GTP binding in response to decreased mitochondrial activity suggesting a revised model for Ras1 and Cyr1 signaling in which Cyr1 and Ras1 influence each other and, together with Ira2, seem to form a master-regulatory complex necessary to integrate different environmental and intracellular signals, including metabolic status, to decide the fate of cellular morphology.…”

Image_4_Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antit... by Loredana Bergandi (4170769)

“…Finally, hyperglycemia reduced cell death by decreasing the cell percentage in sub-G1 peak induced by DOX (via a cell cycle arrest in the G2/M phase) and 5-FU (via a cell cycle arrest in the S phase) in HT29 and LOVO cells. …”

Image_2_Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antit... by Loredana Bergandi (4170769)

“…Finally, hyperglycemia reduced cell death by decreasing the cell percentage in sub-G1 peak induced by DOX (via a cell cycle arrest in the G2/M phase) and 5-FU (via a cell cycle arrest in the S phase) in HT29 and LOVO cells. …”

Data_Sheet_1_Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to... by Loredana Bergandi (4170769)

“…Finally, hyperglycemia reduced cell death by decreasing the cell percentage in sub-G1 peak induced by DOX (via a cell cycle arrest in the G2/M phase) and 5-FU (via a cell cycle arrest in the S phase) in HT29 and LOVO cells. …”