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treatment increases » greater increases (Expand Search)
latest decrease » largest decrease (Expand Search), greatest decrease (Expand Search), largest decreases (Expand Search)
larger decrease » marked decrease (Expand Search)
b larger » _ larger (Expand Search), b large (Expand Search), _ large (Expand Search)
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DIAVIT prevents albuminuria and increased glomerular water permeability in diabetic db/db mice, whilst having no effect on blood glucose.
Published 2019“…<p><b>A)</b> db/db mice develop increased blood glucose at 6–7 weeks of age (week 1 of treatment), compared to lean controls (*p<0.05), which is not affected by DIAVIT consumption (ns; p>0.05; n = 6–9 mice; Two-way ANOVA based on the average values over 14 weeks). …”
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Delphinidin alters VEGF-A splicing to increase VEGF-A<sub>165</sub>b and decrease total VEGF-A expression.
Published 2019“…<p><b>A)</b> Treatment of podocytes with delphinidin chloride (10 μg/ml) under normal glucose (NG; 5 mM glucose + 25 mM mannitol) and high glucose (HG; 30 mM glucose, 1 ng/ml TNFα, 1 ng/ml IL-6, and 100 nM insulin) for 48 hrs increased the protein expression of VEGF-A<sub>165</sub>b relative to total VEGF-A<sub>165</sub> (quantified in <b>B</b>; *p<0.05 vs NG, †p<0.05 vs HG; n = 3 biological repeats; One-way ANOVA with Bonferroni post-hoc test for comparison between pairs; <b>A</b>—the same blot was first probed with VEGF-A<sub>165</sub>b before stripping and reprobing with panVEGF-A). …”
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