Cumulative incidence probability of primary liver cancer (A) and cumulative mortality probability of liver diseases (B) in the vaccination and control groups. by Chunfeng Qu (114656)

Replication Validity of Initial Association Studies: A Comparison between Psychiatry, Neurology and Four Somatic Diseases by Estelle Dumas-Mallet (2851265)

“…Among the 256 initial studies reporting a significant effect (p<0.05) and paired with significant meta-analyses, 97 effect sizes were inflated by more than 100%. …”

Attenuation of CDK expression and cyclin D-CDK4/6 activity by androgen in HPr-1AR. by Young-Chae Kim (163381)

“…Immunoblot analysis of cell lysates reveals that CDK4 and CDK6 protein expression decreased and CDKN1A expression increased with DHT treatment compared to vehicle. …”

AR-mediated transcriptional regulation of cyclin D2, CDK4/6, and CDKN1A pre-mRNAs in HPr-1AR. by Young-Chae Kim (163381)

“…<p>(A) Depiction of QPCR amplicons that were designed to detect various regions of cyclin D1 pre-mRNA and mRNA. …”

Attenuation of CDK expression and cyclin D-CDK4/6 activity by androgen in PC3-Lenti-AR. by Young-Chae Kim (163381)

“…(E) In comparison to control samples, DHT treatment for 24 hours significantly decreased CDK4 and CDK6 mRNAs and pre-mRNAs 1.5 fold or more and increased CDKN1A mRNA and pre-mRNA 2 fold or more, suggesting AR-mediated regulation of transcription at these genes, n = 3. …”

Inhibition of PC3-Lenti-AR cell proliferation in response to androgen. by Young-Chae Kim (163381)

“…(D) In time course experiments, PC3-Lenti-AR cells proliferated in the presence of DHT, albeit at a decreased rate. In comparison to control-treated PC3-Lenti-AR cells, 24%, 36%, and 63% fewer PC3-Lenti-AR cells were present following treatment with DHT for 3, 4, and 6 days (72, 96, and 144 hours), respectively. …”

Regulation of cyclin expression by androgen in HPr-1AR. by Young-Chae Kim (163381)

“…<p>(A) After treatment with 10 nM DHT or vehicle control for 24 hours, total RNA was isolated from HPr-1AR and HPr-1 cells, cDNA was synthesized by reverse transcription and relative levels of cyclin mRNAs were quantified by QPCR analysis. …”

Effects of the different doses of adiponectin on markers of direct oxidative stress (AOPP)(A) and anti-oxidant capacity (FRAP and Nox)(B and C). by Fabio V. Comim (486376)

“…<p>(A)Compared to control cells, adiponectin treatment (in all doses tested) decreased the AOPP levels (ANOVA, P = 0.0003). …”

Inhibition of HPr-1AR cell proliferation in response to androgen. by Young-Chae Kim (163381)

“…(D) In time course experiments, HPr-1AR cells proliferated in the presence of 10 nM DHT, albeit at a decreased rate. In comparison to control-treated HPr-1AR cells, 31%, 48%, and 63% fewer HPr-1AR cells were present following treatment with DHT for 2, 3, and 4 days (48, 72, and 96 hours), respectively. …”

Expected changes in mean fecundity with climate change (for a predicted 2.58°C increase in SST at the end of the century under a high emissions scenario; [49]). by Mariana Álvarez-Noriega (14275263)

“…<p>(<b>a</b>) Expected changes in the mean number of eggs across latitudes for different female sizes. …”

Heat map analysis and the relative expression of proteins in pancreas at the termination of the experiment. by Christopher Mayer (529944)

siRNA oligonucleotide specific for PKA causes decreased expression and activity of PKA and ameliorated the high glucose mediated decrease of G6PD activity. by Zhaoyun Zhang (118032)

“…Figures A and B show that siRNA led to decreased expression and decreased activity of PKA. …”

Overexpression of cyclin D-CDK complex components rescues AR-mediated growth suppression of HPr-1AR. by Young-Chae Kim (163381)

“…<p>(A) Transient overexpression of cyclin D1 and cyclin D2 was validated by immunoblot analysis. …”

SERCA2A expression is regulated by mTORC2. by Angelika Kusch (368579)

“…<p>Rictor silencing was induced by cell transfection with rictor siRNA and then, cells were stimulated with IGF-1 for 24 hours in presence or absence of E2. mTORC2 downregulation was confirmed by abolished Akt-pS473 and resulted in decreased SERCA2A protein expression. Akt-pT308, mTOR and raptor were not negatively affected by rictor silencing. …”

17ß-Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive Cardiac Remodeling by Angelika Kusch (368579)

“…In addition, cardiomyocytes with reduced Akt-pS473 under rapamycin treatment displayed decreased SERCA2A mRNA and protein expression suggesting negative functional consequences on cardiomyocyte contractility. …”

IL-17A, a possible biomarker for the evaluation of treatment response in <i>Trypanosoma cruzi</i> infected children: A 12-months follow-up study in Bolivia by Clara Vásquez Velásquez (7429844)

“…</p><p>Within 14 Th1/Th2/Th17 cytokines, IL-17A showed significantly higher levels in seropositive children before the treatment compared to age-matched seronegative children and significantly decreased to the normal level one-year after. …”

Body distribution of <i>P</i>. <i>mirabilis</i> in tumor-bearing mice. by Hong Zhang (25820)

“…<p>(A) The bacteria were detected in tumors and other organs, including heart, liver, spleen, lung and kidney at 0, 6, 24, 48, 72, and 96 hours after <i>P</i>. …”

The therapeutic effect of <i>P</i>. <i>mirabilis</i> in 4T1 solid tumor model. by Hong Zhang (25820)

“…<p>(A) Bacterial treatment suppressed tumor growth at the end of the experiment. …”

siRNA knockdown of TGFβ1 in NTM cells led to an increase in RASAL1 expression by Western blotting. by Fiona McDonnell (2636635)

“…This indicates that when TGFβ1 is decreased, its pathway is also affected. Further, a decrease in TGFβ1 expression by siRNA treatment also led to an increase in RASAL1 protein expression B, a decrease in COL1A1 expression C and a decrease in DNMT1 expression D. …”

Effects of busulfan treatment (6 mg/kg) on the epididymis and sperm of mice over a three-week period. by Lingjun Zhao (21763122)

“…<p>(A) The epididymal sperm concentrations decrease over time and significantly differ between hour 0 (control) and day 21 (<i>n </i>= 3 per group). …”