<i>FTO</i> Obesity Risk Variants Are Linked to Adipocyte <i>IRX3</i> Expression and BMI of Children - Relevance of <i>FTO</i> Variants to Defend Body Weight in Lean Children? by Kathrin Landgraf (350164)

“…</p><p>Conclusion</p><p>One interpretation of our observation of <i>FTO</i> risk variants linked to <i>IRX3</i> expression and adipocyte size restricted to lean children, along with the decreased <i>IRX3</i> expression in obese compared to lean peers, may reflect a defense mechanism for protecting body-weight, which is pertinent for lean children.…”

Image_1_B Cell and CD4 T Cell Interactions Promote Development of Atherosclerosis.tif by Christopher Tay (335988)

“…These findings suggest that targeting B cell and CD4 T cell interaction may be a therapeutic strategy to limit atherosclerosis progression.…”

Table_2_Modulation of Fermentation Quality and Metabolome in Co-ensiling of Sesbania cannabina and Sweet Sorghum by Lactic Acid Bacterial Inoculants.docx by Tianqi Xia (5558435)

“…<p>Sesbania cannabina (SC) is a protein-rich roughage that thrives under moderate-severe saline-alkali (MSSA) soils with the potential to relieve the shortage of high nutritive forage. …”

Supplementary file 1_Spatial-temporal evolution characteristics and driving factors of carbon emission prediction in China-research on ARIMA-BP neural network algorithm.pdf by Sanglin Zhao (20915732)

“…The results show that: (1) From 2000 to 2035, China’s total carbon emissions increased year by year, but the growth rate of carbon emissions gradually decreased; The carbon emission structure is “secondary industry > residents’ life > tertiary industry > primary industry”, and the growth rate of carbon in secondary industry and residents’ life is faster, while the change trend of primary industry and tertiary industry is smaller; (2) The spatial distribution of carbon emissions in China’s provinces presents a typical pattern of “eastern > central > western” and “northern > southern”, and the carbon emission centers tend to move to the northwest; (3) The regions with high level of digital economy, advanced industrial structure and new quality productivity have relatively less carbon emissions, which has significant group difference effect; (4) The intensity effect of energy consumption is the main factor driving the continuous growth of carbon emissions, while the per capita GDP and the structure effect of energy consumption are the main factors restraining carbon emissions, while the effects of industrial structure and population size are relatively small. …”

Table_3_LncRNA TCF7 Promotes Epithelial Ovarian Cancer Viability, Mobility and Stemness via Regulating ITGB8.docx by Changlei Su (11717234)

“…It also correlates with advanced tumor features and poor prognosis in EOC, implying its potential as a target for EOC treatment.</p>…”

Table7_Correlation Between Immune-Related Genes and Tumor-Infiltrating Immune Cells With the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer.XLSX by Yan Zhou (6523)

“…Among the many biomarkers predicting the efficacy of NAC, immune-related biomarkers, such as immune-related genes and tumor-infiltrating lymphocytes (TILs), play a key role.</p><p>Methods: We analyzed gene expression from several datasets in the Gene Expression Omnibus (GEO) database and evaluated the relative proportion of immune cells using the CIBERSORT method. …”

Two Kinds of Ferritin Protect Ixodid Ticks from Iron Overload and Consequent Oxidative Stress by Remil Linggatong Galay (327972)

“…We previously reported that the hard tick <i>Haemaphysalis longicornis</i> has an intracellular (HlFER1) and a secretory (HlFER2) ferritin, and both are crucial in successful blood feeding and reproduction. …”

Image 9_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.tif by Zhuowen Hu (20431616)

“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”

Table_9_Alterations of the gut microbiota in patients with immunoglobulin light chain amyloidosis.xlsx by Jipeng Yan (8473710)

“…Notably, 5 optimal ASV-based microbial markers were identified as the diagnostic model of AL amyloidosis and the AUC value of the train set and the test set was 0.8549 (95% CI 0.7310-0.9789) and 0.8025 (95% CI 0.5771-1), respectively. With a median follow-up of 19.0 months, further subgroup analysis also demonstrated some key gut microbial markers were related to disease severity, treatment response, and even prognosis of patients with AL amyloidosis.…”

Table_3_LncRNA TCF7 Promotes Epithelial Ovarian Cancer Viability, Mobility and Stemness via Regulating ITGB8.docx by Changlei Su (11717234)

“…It also correlates with advanced tumor features and poor prognosis in EOC, implying its potential as a target for EOC treatment.</p>…”

Data_Sheet_1_Diatom Biodiversity and Speciation Revealed by Comparative Analysis of Mitochondrial Genomes.ZIP by Yichao Wang (399833)

“…Synteny analyses of mtDNAs uncovered high conservation among species within an order, but extensive rearrangements including translocations and/or inversions between species of different orders within a class. Duplication of cox1 was discovered for the first time in diatoms in Nitzschia traheaformis and Haslea tsukamotoi. …”

The Tumor Suppressors <i>p53</i> and <i>VHL</i> Are Inhibited in the KSHV Latently Infected and LANA-Expressing Cells by Qi-Liang Cai (274444)

“…<div><p>(A) IB analysis of KSHV-positive cell lines (BC-3, BCBL-1, JSC-1, and BC-1) and KSHV-negative cell lines (BJAB, DG-75, and Louckes) against <i>p53</i>, <i>VHL,</i> and β-actin. …”

DataSheet1_Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice.docx by Lu Xia (1509745)

“…</p><p>Conclusion: GSDMD-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures. Our study provides a new potential therapeutic target for seizure control.…”

DataSheet_1_Risk stratification based on DNA damage-repair-related signature reflects the microenvironmental feature, metabolic status and therapeutic response of breast cancer.doc... by Chunzhen Li (14835418)

“…Integrating public datasets and bioinformatics algorithms, we developed a robust prognostic signature based on 27 DRGs. …”

Image_5_10-Hydroxydec-2-Enoic Acid Reduces Hydroxyl Free Radical-Induced Damage to Vascular Smooth Muscle Cells by Rescuing Protein and Energy Metabolism.TIF by Pei Fan (404125)

“…To the best of our knowledge, our results provide the first concrete evidence that 10-HDA-scavenged •OH could be a potential pharmacological application for maintaining vascular health.…”

DataSheet3_Lateral impact response of circular hollow steel tubes with mid-span localized penetrating notches.docx by Xiaoli Huang (309237)

“…The results showed that under a lateral impact load, the mid-span of the CHST column presented global bending failure patterns accompanied by local indentation deformation in the impact region and local buckling deformation at the bottom of the fixed end. …”

Data Sheet 3_Rapid reshaping of the soil microbiome and metabolome during short-term flooding and draining in rice.docx by Yanyao Lu (22163632)

“…However, the specific effects of different drainage durations on soil microorganisms and metabolites remain unclear. This study adopted a multi-omics research method. After nontargeted metabolomics analysis of lipids as the main metabolite, microbial diversity analysis and lipidomics analysis were conducted to determine the main influencing factors. …”

Presentation_1_E3 ligase RNF5 inhibits type I interferon response in herpes simplex virus keratitis through the STING/IRF3 signaling pathway.PPTX by Zhi Liu (165121)

“…<p>Herpes simplex keratitis (HSK), caused by the herpes simplex virus 1 (HSV-1), is a major blinding disease in developed countries. …”

Image_4_The Interaction Mechanism Between Herpes Simplex Virus 1 Glycoprotein D and Host Antiviral Protein Viperin.jpg by Meili Li (286549)

“…<p>Viperin is an interferon-inducible protein that responsible for a variety of antiviral responses to different viruses. …”

Projected climate change threatens pollinators and crop production in Brazil by Tereza Cristina Giannini (4344664)

“…The decline in the probability of pollinator occurrence is found in a large number of municipalities with the lowest GDP and will also likely affect some places where crop production is high (20% to 90% of the GDP) and where the number of inhabitants is also high (more than 6 million people). …”