Video_4_The Protective Effect of Vanadium on Cognitive Impairment and the Neuropathology of Alzheimer’s Disease in APPSwe/PS1dE9 Mice.MP4 by Zhijun He (6004220)

“…Further investigation revealed that BEOV significantly reduced Aβ generation by increasing the expression of peroxisome proliferator-activated receptor gamma and insulin-degrading enzyme and by decreasing β-secretase 1 in the hippocampus and cortex of AD mice. …”

DataSheet_1_Corilagin Ameliorates Con A-Induced Hepatic Injury by Restricting M1 Macrophage Polarization.zip by Fenglian Yan (6322787)

“…<p>Immune-mediated hepatic injury plays a key role in the initiation and pathogenesis of diverse liver diseases. …”

DataSheet1_Molecular insights into disease-associated glutamate transporter (EAAT1 / SLC1A3) variants using in silico and in vitro approaches.docx by Marina Gorostiola González (17437326)

“…Depending on the tumor site, cancer cells have increased or decreased expression of excitatory amino acid transporter 1 or 2 (EAAT1/2, SLC1A3/2) to regulate glutamate uptake for the benefit of tumor growth. …”

S252W mutation affected Wnt signaling in osteogenically differentiating BMSCs. by Li Zhang (8200)

“…<p>(A) Cluster analysis of a microarray data revealed that Wnt pathway antagonists SRRP1, SFRP2, and SFRP4 were up-regulated 3.8 fold, 2.5 fold, and 2.9 fold in mutant BMSCs, respectively (<i>n</i> = 3). …”

High domain conservation in NS1 groups, subgroups and lineages. by Edgar E. Sevilla-Reyes (410203)

“…F103 and M106 are indispensable for CPSF30 binding <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0063098#pone.0063098-Kochs1" target="_blank">[33]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0063098#pone.0063098-Twu1" target="_blank">[34]</a>; FMKDD motif results in strong binding, while FMREG results in weak binding <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0063098#pone.0063098-Hale2" target="_blank">[32]</a>. …”

DataSheet_1_Identification of a Pharmacological Biomarker for the Bioassay-Based Quality Control of a Thirteen-Component TCM Formula (Lianhua Qingwen) Used in Treating Influenza A... by Dan Gao (410390)

“…Pharmacological experiments indicated that LHQW could treat influenza A virus (H1N1) infection in the H1N1 mouse model, as claimed in clinical trials, by improving pathologic alterations and bodyweight loss, and decreasing virus replication, lung lesions and inflammation. …”

DataSheet_1_DHW-221, a Dual PI3K/mTOR Inhibitor, Overcomes Multidrug Resistance by Targeting P-Glycoprotein (P-gp/ABCB1) and Akt-Mediated FOXO3a Nuclear Translocation in Non-small... by Mingyue Liu (1519720)

“…Here, we reported for the first time that DHW-221 had favorable antiproliferative activity and suppressed cell migration and invasion in A549/Taxol cells in vitro and in vivo. Importantly, DHW-221 acted as a P-gp inhibitor via binding to P-gp, which resulted in decreased P-gp expression and function. …”

Transcriptomic Analysis of Human Polarized Macrophages: More than One Role of Alternative Activation? by Eleonora Derlindati (709644)

“…When compared to RM, M1 significantly upregulated pathways involved in immunity and inflammation, whereas M2a did the opposite. Conversely, decreased and increased expression of mitochondrial metabolism, consistent with insulin resistant and insulin sensitive patterns, was seen in M1 and M2a, respectively. …”

Table2_The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance.docx by Sophia N. Verouti (7240817)

“…We showed that increased hepatic insulin receptor expression and decreased ZnT8 (slc30a8) metal ion transporter mRNA expression are associated with this phenotypic change. …”

Image_1_Long Noncoding RNA OR7E156P/miR-143/HIF1A Axis Modulates the Malignant Behaviors of Glioma Cell and Tumor Growth in Mice.tif by Haiting Zhao (11239707)

“…OR7E156P was intricately linked to the HIF1A pathway. Hypoxia could induce OR7E156P expression, whereas OR7E156P silencing decreased HIF1A protein levels under hypoxic conditions. …”

p38α MAPK expression is diminished in UV-irradiated A431 SCC keratinocytes and human SCCs. by Liang Liu (50022)

“…<p>UV decreases p38α expression in A431 cells. The mRNA levels of p38α, β, γ, and δ were determined by real-time qRT-PCR in normal human keratinocytes (NHK) and human A431 cells, 24 h after UV irradiation (30 mJ/cm²).; The data shown are from a representative experiment of three different sets of independent experiments using keratinocytes derived from independent donors. …”

Image_2_The P2X7 Receptor 489C>T Gain of Function Polymorphism Favors HHV-6A Infection and Associates With Female Idiopathic Infertility.tif by Anna Pegoraro (8213589)

“…We show that functional P2X7R increases while its blockade decreases viral load. Interestingly, HHV-6A infection was enhanced in HEK293 cells transfected with P2X7R cDNA bearing the gain of function 489C>T SNP (rs208294, replacing a histidine for tyrosine at position 155). …”

Image_3_Long Noncoding RNA OR7E156P/miR-143/HIF1A Axis Modulates the Malignant Behaviors of Glioma Cell and Tumor Growth in Mice.tif by Haiting Zhao (11239707)

“…OR7E156P was intricately linked to the HIF1A pathway. Hypoxia could induce OR7E156P expression, whereas OR7E156P silencing decreased HIF1A protein levels under hypoxic conditions. …”

Image_2_Long Noncoding RNA OR7E156P/miR-143/HIF1A Axis Modulates the Malignant Behaviors of Glioma Cell and Tumor Growth in Mice.tif by Haiting Zhao (11239707)

“…OR7E156P was intricately linked to the HIF1A pathway. Hypoxia could induce OR7E156P expression, whereas OR7E156P silencing decreased HIF1A protein levels under hypoxic conditions. …”

Image_4_Long Noncoding RNA OR7E156P/miR-143/HIF1A Axis Modulates the Malignant Behaviors of Glioma Cell and Tumor Growth in Mice.tif by Haiting Zhao (11239707)

“…OR7E156P was intricately linked to the HIF1A pathway. Hypoxia could induce OR7E156P expression, whereas OR7E156P silencing decreased HIF1A protein levels under hypoxic conditions. …”

The Effect of Orexin-A on Cardiac Dysfunction Mediated by NADPH Oxidase-Derived Superoxide Anion in Ventrolateral Medulla by Jun Chen (4238)

“…HRV power spectral analysis showed that exogenous OXA led to decreased HF component of HRV and increased LF/HF ratio in comparison with aCSF, which suggested that OXA might be related to sympathovagal imbalance. …”

Table_1_Re-Evaluation of the Survival Paradox Between Stage IIB/IIC and Stage IIIA Colon Cancer.xlsx by Hongbo Li (130443)

“…</p>Results<p>In the current study, a total of 9,227 eligible colon cancer patients were collected from the SEER database between 2010 and 2015. …”

Gastrointestinal Symptoms are Still Prevalent and Negatively Impact Health-Related Quality of Life: A Large Cross-Sectional Population Based Study in The Netherlands by Merel M. Tielemans (438925)

“…The aim of this study was to assess the current prevalence of gastrointestinal symptoms, appraise associated factors and assess health-related quality of life in the general population.</p><p>Methods</p><p>A total of 51,869 questionnaires were sent to a representative sample of the Dutch adult general population in December 2008. …”

Table1_The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance.docx by Sophia N. Verouti (7240817)

“…We showed that increased hepatic insulin receptor expression and decreased ZnT8 (slc30a8) metal ion transporter mRNA expression are associated with this phenotypic change. …”

Table_2_Downregulation of Methyltransferase-Like 14 Promotes Ovarian Cancer Cell Proliferation Through Stabilizing TROAP mRNA.xlsx by Yize Li (471459)

“…In conclusion, METTL14 overexpression decreased ovarian cancer proliferation by inhibition of TROAP expression via an m⁶A RNA methylation-dependent mechanism.…”