A novel mutation in ext2 caused hereditary multiple exostoses through reducing the synthesis of heparan sulfate by Caixia Xian (12820484)

“…Although the resulting truncated protein was still localized to the Golgi, similar to the full-length EXT2, its HS synthesis activity decreased by 40%. In this study, a novel splice site mutation in ext2 was identified and suggested to be a pathogenic mutation of HME, which may expand the genetic etiology spectrum of HME and may be helpful for clinical genetic counseling and prenatal diagnosis.…”

Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Promotes Wound Repair and Post-MI Cardiac Remodeling by Sarika Saraswati (236578)

“…Pyrvinium reduced adverse cardiac remodeling demonstrated by decreased left ventricular internal diameter in diastole (LVIDD) as compared to a control compound. …”

Presentation1_Menopause and facial skin microbiomes: a pilot study revealing novel insights into their relationship.pdf by Martin Patrick Pagac (18191266)

“…However, this work reports for the first time a direct association between menopausal status and facial microbiomes on skin of similarly aged study participants, and hence uncouples aging-associated skin biophysical parameters, such as viscoelastic properties, from the equation. …”

Identification of <i>SFL1</i> as a positive regulator for flor formation in <i>Zygosaccharomyces rouxii</i> by Ryosuke Mogi (8484966)

“…Unexpectedly, <i>SFL1</i> knockout mutant could only form a very weak flor due to decreased <i>FLO11D</i> expression, suggesting that <i>SFL1</i> acts as a potential activator of flor formation through <i>FLO11D</i> expression. …”

Identification of a 31-bp Deletion in the <i>RELN</i> Gene Causing Lissencephaly with Cerebellar Hypoplasia in Sheep by Aroa Suárez-Vega (487116)

“…A functional analysis of this mutation revealed decreased levels of <i>RELN</i> mRNA and a lack of reelin protein in the brain cortex and blood of affected lambs. …”

Data_Sheet_1_Energetic Effects of Whale-Watching Boats on Humpback Whales on a Breeding Ground.xlsx by Damian Villagra (9967580)

“…<p>Interactions between whale-watching boats and cetaceans can lead to changes in their behavior. From a management perspective, it is important to understand how this type of disturbance can be translated into physiological effects, such as changes in their energetic metabolism. …”

Table4_m6A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement.XLSX by Wenzheng Qu (11617021)

“…Notably, EE exposure decreased the protein level of m⁶A eraser Fto, but did not affect the protein level of m⁶A writers METTL3 and METTL14. …”

Image1_m6A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement.TIFF by Wenzheng Qu (11617021)

“…Notably, EE exposure decreased the protein level of m⁶A eraser Fto, but did not affect the protein level of m⁶A writers METTL3 and METTL14. …”

Supplementary Material for: Spinal cord stimulation for diffuse visceral hyperalgesia in the abdomen: a case report and literature review by figshare admin karger (2628495)

“…However, this has been explored only when the pain has a clear dermatomal association such as the right upper quadrant for sphincter of Oddi dysfunction or the left upper quadrant for post-traumatic splenectomy. …”

<i>Arabidopsis</i> DELLA Protein Degradation Is Controlled by a Type-One Protein Phosphatase, TOPP4 by Qianqian Qin (202246)

“…<div><p>Gibberellins (GAs) are a class of important phytohormones regulating a variety of physiological processes during normal plant growth and development. …”

A Rigidifying Salt-Bridge Favors the Activity of Thermophilic Enzyme at High Temperatures at the Expense of Low-Temperature Activity by Sonia Y. Lam (227538)

“…One hypothesis to explain this observation is that the extra stabilizing interactions increase the rigidity of thermophilic enzymes and hence reduce their activity. Here we employed a thermophilic acylphosphatase from <em>Pyrococcus horikoshii</em> and its homologous mesophilic acylphosphatase from human as a model to study how local rigidity of an active-site residue affects the enzymatic activity.…”

Supplementary Material for: Role of Peroral Endoscopic Myotomy in Geriatric Patients with Achalasia: A Systematic Review and Meta-Analysis by Zhong C. (3931220)

“…<b><i>Background:</i></b> Peroral endoscopic myotomy (POEM) is a particularly attractive intervention for achalasia. …”

γ-H2AX Kinetics as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers by Shibo Fu (154768)

“…<div><h3>Background</h3><p>Persistence of γ-H2AX after ionizing radiation (IR) or drug therapy is a robust reporter of unrepaired DNA double strand breaks in treated cells.…”

Refining Climate Change Projections for Organisms with Low Dispersal Abilities: A Case Study of the Caspian Whip Snake by Tiberiu C. Sahlean (543396)

“…Both models agreed on an expansion of suitable area northwards, with minor decreases at the southern distribution limit. The MDR area calculated using the Maxent model represented a third of the total area of the projected model. …”

Table1_m6A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement.XLSX by Wenzheng Qu (11617021)

“…Notably, EE exposure decreased the protein level of m⁶A eraser Fto, but did not affect the protein level of m⁶A writers METTL3 and METTL14. …”

Species-specific differences in primate CMV TRS1 PKR antagonism map to a single amino acid. by Kathryn S. Carpentier (3240141)

“…Transfection of PKR leads to decreased activity of a co-transfected reporter construct expressing SEAP. …”

A kinetic and mechanistic study of heterodinuclear Ru(II)–Pt(II) complexes of flexible polyethyleneglycol ether linkers by Aishath Shaira (20726535)

“…The ligand substitution kinetics of the complexes with thiourea (TU), 1,3-dimethyl-2-thiourea (DMTU), 1,1,3,3-tetramethyl-2-thiourea (TMTU) and iodide (I^-) were investigated under pseudo first-order conditions as a function of concentration and temperature using conventional Stopped-Flow techniques. …”

Quality of milk fat obtained from cows and buffaloes fed a diet supplemented with flaxseed or soybean oils by Ahmed Behdal Shazly (8402256)

“…Cholesterol content decreased in cow's AMF while increased in buffalo's AMF when a diet supplemented with FO, SO, or FSO. …”

<i>C. elegans</i> learn and remember a positive association between food and the weak chemoattractant butanone. by Amanda L. Kauffman (249057)

“…<p>(A) Positive associative olfactory learning and memory assays. …”

The Shade Avoidance Syndrome in Arabidopsis: The Antagonistic Role of Phytochrome A and B Differentiates Vegetation Proximity and Canopy Shade by Jaime F. Martínez-García (204118)

“…We have systematically analyzed the Arabidopsis seedling response and the contribution of phyA and phyB to perception of decreased R:FR, at three different levels of photosynthetically active radiation. …”