Concomitant Targeting of EGF Receptor, TGF-beta and Src Points to a Novel Therapeutic Approach in Pancreatic Cancer by Sophie Deharvengt (155564)

“…<div><p>To test the hypothesis that concomitant targeting of the epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-β) may offer a novel therapeutic approach in pancreatic cancer, EGFR silencing by RNA interference (shEGFR) was combined with TGF-β sequestration by soluble TGF-β receptor II (sTβRII). …”

Image 1_Case Report: Concurrent atrial and ventricular septal defect in a young Sphynx cat.jpeg by Jihoon Lee (784361)

“…<p>Concurrent atrial septal defect (ASD) and ventricular septal defect (VSD) are rare in cats. A 7-month-old intact female Sphynx cat was presented for evaluation of respiratory distress and exercise intolerance. …”

Data_Sheet_1_Are medication-induced salivary changes the culprit of osteonecrosis of the jaw? A systematic review.PDF by Isti Rahayu Suryani (16911132)

“…Patients administered with bisphosphonates, steroids, chemotherapy, thalidomide, interferon, and hormone therapy had a significantly higher association between decreased salivary flow and MRONJ occurrence. …”

Datasheet1_When amiodarone-induced thyroiditis meets cardiomyopathy with excessive trabeculation: a case report.pdf by Dora Gašparini (16628640)

“…Introduction<p>Amiodarone is a potent antiarrhythmic medication used to treat life-threatening ventricular arrhythmias; however, its well-established adverse effect is a thyroid disorder. …”

DataSheet_2_Identification of a 3-Gene Model as Prognostic Biomarker in Patients With Gastric Cancer.xlsx by Siming Xue (13041795)

“…Objective<p>Although the incidence of gastric cancer (GC) is decreasing, GC remains one of the leading cancers in the world. …”

Screening of a drug library for agents that upregulate CD9 or CD81 in RAW264.7 macrophages. by Yingji Jin (456327)

“…<p>(<b>A</b>) RAW264.7 cells were cultured for 24 h in the absence (V, vehicle alone) and presence of each drug (10 µM). …”

Data Sheet 1_Determinants of pneumococcal carriage by age in Africa (2000–2021): a systematic analysis.docx by Eliza Mari Kwesi-Maliepaard (14072391)

“…Special emphasis should be given to the elderly population, since they are understudied and have a higher burden of infectious diseases in general. …”

Data_Sheet_1_Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population.PDF by Elias G. Thomas (12965714)

“…Introduction<p>Globally, women with dementia have a higher disease burden than men with dementia. …”

Table_3_CodY Is a Global Transcriptional Regulator Required for Virulence in Group B Streptococcus.DOCX by Angelica Pellegrini (12472515)

“…<p>Group B Streptococcus (GBS) is a Gram-positive bacterium able to switch from a harmless commensal of healthy adults to a pathogen responsible for invasive infections in neonates. …”

Nanoscale quantification of the biophysical characterization of combretastatin A-4-treated tumor cells using atomic force microscopy by Yanchun Li (248761)

“…<div><p>As an inhibitor of microtubule assembly, combretastatin A-4 (CA-4)-induced biological responses in tumor cells have been well known, but the corresponding changes in nano-biophysical properties were not investigated given the lack of an ideal tool. …”

Table 2_Outcomes after liposuction-based treatment of lymphedema: a systematic review and meta-analysis.docx by Junzhe Chen (5729912)

“…Background<p>Lymphedema, a chronic condition involving lymphatic fluid accumulation, affects over 250 million people worldwide. …”

Image_2_TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer.TIF by Mengdi Yang (8995346)

“…<p>The treatment and prognosis of advanced colorectal cancer (CRC) remain a challenging clinical research focus. Here, we describe a new CRC tumor suppressor and potential therapeutic target: thymocyte selection associated high mobility group box (TOX) protein. …”

Table_2_A Conserved Requirement for Fbxo7 During Male Germ Cell Cytoplasmic Remodeling.xlsx by Claudia C. Rathje (7482146)

“…Consistent with the fly model, we observe a reduction in PI31 levels in mutant mice; however, there is no alteration in proteasome activity in whole mouse testes. …”

Table1_Endothelial anthrax toxin receptor 2 plays a protective role in liver fibrosis.docx by Xiaojuan Huang (1957396)

“…ANTXR2 expression in the liver endothelium of wild-type (WT) mice significantly decreased after a 4-time sequential injection of carbon tetrachloride (CCl₄) to induce liver fibrosis. …”

Image_2_A Novel Homozygous Mutation Destabilizes IKKβ and Leads to Human Combined Immunodeficiency.jpeg by Tao Qin (177288)

“…Targeted gene panel sequencing revealed a novel homozygous missense mutation in the IKBKB gene of a patient with immune dysregulation and combined T and B cell functional defects. …”

RNA Sequencing Reveals a Slow to Fast Muscle Fiber Type Transition after Olanzapine Infusion in Rats by Christopher J. Lynch (210400)

“…Male Sprague-Dawley rats were infused intravenously with vehicle or olanzapine for 24h using a dose leading to a mild hyperglycemia. RNA-Seq was performed on gastrocnemius muscle, followed by alignment of the data with the Rat Genome Assembly 5.0. …”

Video_1_Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model.MP4 by Ravikanth Velagapudi (7880072)

“…<p>Postoperative delirium is a frequent and debilitating complication, especially amongst high risk procedures such as orthopedic surgery, and its pathogenesis remains unclear. …”

Image 1_Immunosuppressants in dermatology on vaccine immunogenicity: a prospective cohort study of pemphigus patients in the pandemic.tif by Kun-Lin Lu (7256960)

“…COVID-19 vaccinations spaced at least six months after the last rituximab infusion did not cause a significant difference in anti-viral T-cell or antibody responses between rituximab-naïve and rituximab-treated patients. …”

Table1_Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway.pdf by Ting Zeng (1521649)

“…Transcriptome sequencing and bioinformatics analysis results showed that in cobll1a knockout group, the expression level of genes in the Retinoic Acid (RA) signaling pathway was affected, and the expression level of lipid metabolism-related genes (fasn, scd, elovl2, elovl6, dgat1a, srebf1 and srebf2) were significantly changed (p < 0.01), leading to increased lipid synthesis and decreased lipid catabolism. …”

The Asian house shrew <i>Suncus murinus</i> as a reservoir and source of human outbreaks of plague in Madagascar by Soanandrasana Rahelinirina (179752)

“…<i>murinus</i> and <i>Xenopsylla cheopis</i> since the epidemics appears to have decreased the frequency of spillover events to the more susceptible rats, which act as a source of infection for humans. …”