siRNA screen for DNA repair factors associated with HIV infection revealed a role for the BER pathway. by Amy S. Espeseth (226760)

“…<i>(C)</i> Diagram of the BER pathway based on <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017612#pone.0017612-Sancar1" target="_blank">[13]</a>. siRNAs targeting BER factors colored yellow decreased HIV infectivity by at least 40%, siRNAs targeting BER factors colored red increased HIV infectivity by at least 2×. siRNAs targeted BER factors colored blue had no effect on HIV infection.…”

Table 1_Proteomic insights into COPD pathogenesis and therapeutic targets: a causal analysis of circulating proteins.docx by Min Luo (258201)

“…Background<p>Chronic obstructive pulmonary disease (COPD) is a preventable and treatable condition, yet current therapies do not halt disease progression, highlighting the need for novel treatments. …”

DataSheet1_A Metabolic Profiling Study of Realgar-Induced Acute Kidney Injury in Mice.xls by Sheng Zhang (111330)

“…Principal component analysis (PCA), correlation analysis, and pathway analysis were used to detect the nephrotoxic effects of Realgar. Body weight decreased significantly in the 2.0 g/kg group, and the kidney weight index also showed a dose-dependent increase in Realgar. …”

Image_1_Auranofin coated catheters inhibit bacterial and fungal biofilms in a murine subcutaneous model.tif by LewisOscar Felix (13135377)

“…To reduce microbial adhesion, murine and human catheters were coated with polyurethane and auranofin using a dip coating method and compared to non-coated materials. …”

<b>Altered molecular regulation of TUG is a central feature of insulin resistant human adipose tissue</b> by Jordan W. Strober (22613649)

“…<p dir="ltr">White adipose tissue (WAT) insulin resistance (IR) is a central feature of the metabolic syndrome, yet data regarding defects in WAT insulin signaling in humans with IR is limited. …”

DataSheet_1_Hsa-miR-133a-3p, miR-1-3p, GOLPH3 and JUP combination results in a good biomarker to distinguish between prostate cancer and non-prostate cancer patients.pdf by Rocío Belén Duca (14004705)

“…Hsa-miR-133a-3p/1-3p expression levels were significantly decreased in PCa compared to normal tissues while hsa-miR-133a-3p was found to be further decreased in metastatic prostate cancer tumors compared to non-metastatic PCa. …”

File S1 - AFLPs and Mitochondrial Haplotypes Reveal Local Adaptation to Extreme Thermal Environments in a Freshwater Gastropod by María Quintela (122518)

“…Colors in the diagrams follow a decreasing thermal trend (i.e. warmest populations are depicted in the darkest colors). …”

Inhibition of AurA or HDAC6 by inhibitors preserves ciliary structure during porcine CoVs infection. by Tenghan Zhuang (22238809)

“…Tubacin treatment increased AcTub levels, while PHA-680632 (PHA) treatment decreased pAurA levels, indicating successful inhibition of AurA and HDAC6. …”

Provision of FOLE or SEFA-6179 to mice receiving a fat-free high carbohydrate diet prevents hepatosteatosis. by Bennet S. Cho (6944669)

“…<p>6-week-old male C57Bl6/J mice received an <i>ad lib</i> liquid fat-free high carbohydrate diet (HCD) with every other day orogastric gavage of saline, medium-chain triglyceride vehicle (MCT), fish oil lipid emulsion (FOLE), or SEFA-6179 (in MCT vehicle) at a low or high dose (A, created with biorender.com). …”

Proliposome tablets manufactured using a slurry-driven lipid-enriched powders: Development, characterization and stability evaluation by Khan I.

“…Proliposome powders were prepared via a slurry method using sorbitol or D-mannitol as carbohydrate carriers in 1:10 or 1:15 w/w lipid phase to carrier ratios. …”
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Association between metabolically healthy obesity and metastasis in lung cancer patients – a systematic review and meta-analysis by Malki, Ahmed

“…A statistically significant decreased risk of LC (pooled RR = 0.72, 95% CI: 0.68 to 0.77) was also observed in the obese individuals. …”
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Mental health, burnout and resilience in community pharmacists during the COVID-19 pandemic: A cross-sectional study by Zeana, Samir AlKudsi

“…BackgroundThe study aimed to assess burnout, resilience, and levels of depression, anxiety, stress and fear among community pharmacists during the pandemic, and examine if fear of COVID-19 is associated with these outcomes of interest. MethodsA cross-sectional survey of community pharmacists in Qatar was conducted. …”
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Improved Traffic Flow Efficiency during Yellow Interval at Signalized Intersections Using a Smart Countdown System by Hussain, Qinaat

“…Data such as vehicle lateral or longitudinal position, travel speed, acceleration or deceleration, and violation tickets were collected for each participant using the STISIM Drive®Software. Results from a binary logistic regression model showed that the probability of crossing during the change interval significantly increased for the G-LED condition compared to the control condition, while it decreased in the F-green condition. …”
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A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase by Thirumal Kumar, D

“…MDS run showed that the C145A mutant demonstrated higher structural deviation, decreased compactness, and the binding patterns. …”
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Video6_A Stable Chemokine Gradient Controls Directional Persistence of Migrating Dendritic Cells.mp4 by Thomas Quast (249407)

“…In contrast to Dictyostelium amoeba, DCs are unable to decode oscillatory stimulation of soluble chemokine traveling waves into a directional response toward the wave source. …”

Image_1_Characterization of a de novo GABBR2 variant linked to autism spectrum disorder.JPEG by Noa Bielopolski (17437437)

“…Functional assays confirmed the MD predictions, as evidenced by increased constitutive activity and enhanced potency of GABA for GABBR2 p.Arg212Gln, and a decreased constitutive activity with a loss of GABA potency for GABBR2 p.Arg212Trp. …”

Ectopic Pregnancy as a Model to Identify Endometrial Genes and Signaling Pathways Important in Decidualization and Regulated by Local Trophoblast by W. Colin Duncan (209189)

“…There were no differences in <em>PRL</em> or <em>IGFBP1</em> expression in the decidualization-matched samples but a marked reduction (<em>P</em><0.001) in the non-decidualized samples. …”

Table_1_The Effect of Physical Activity on Neurotrophin Concentrations and Cognitive Control in Patients With a Depressive Episode.pdf by Anna Jasińska-Mikołajczyk (12451383)

“…The patients made more mistakes after physical exercise, both in part A (0.2 vs. 1.5) and B (0.6 vs. 1.5). The so-called interference effect decreased—the difference between naming and reading times was smaller after exercise (6.2 s vs. 2.4 s). …”

Motor Network Plasticity and Low-Frequency Oscillations Abnormalities in Patients with Brain Gliomas: A Functional MRI Study by Chen Niu (343397)

“…All subjects performed a motor task to help identify individual motor activity in the bilateral primary motor cortex (PMC) and supplementary motor area (SMA). …”

Table_2_A Comprehensive Analysis of Population Differences in LRRK2 Variant Distribution in Parkinson's Disease.DOCX by Li Shu (5767922)

“…</p><p>Results: In the absence of obvious heterogeneities and publication biases among the included studies, we concluded that A419V, R1441C/G/H, R1628P, G2019S, and G2385R were associated with increased PD risk (p: 0.001, 0.0004, < 0.00001, < 0.00001, and < 0.00001, respectively), while R1398H was associated with decreased risk (p: < 0.00001). …”