Data Sheet 5_Mechanistic study of the hsa_circ_0074158 binding EIF4A3 impairing sepsis-induced endothelial barrier.zip by Haiyan Liao (6100043)

“…Mechanistically, RNA pull-down and RNA RIP assays demonstrated that hsa_circ_0074158 directly binds to the RNA-binding protein (RBP) EIF4A3, which decreases the stability of CTNNA1 (mRNA) and the production of α-catenin, subsequently impairing endothelial barrier function in sepsis. …”

The Δ15N deletion abolished A3H HapII anti-viral activity and virion incorporation. by Anjie Zhen (313428)

“…<p>To compare anti-viral activity and packaging of A3H HapII and HapIIΔ15N, pNL4–3Δvif was transfected with decreasing doses of A3H HapII and HapIIΔ15N. …”

The perturbed expression of m6A in parthenogenetic mouse embryos by Jindong Hao (8045717)

“…Furthermore, immunofluorescence was used to detect m6A expression. The results demonstrated that m6A expression decreased in the 2-cell stage, whereas it increased in the 8-cell stage of PA embryos. …”

Nakasone. AJP supple Table1, 2, 3 by Toru Aizawa (9001298)

“…Note that <em>increased</em> eGFR is a protective factor so that risk from <em>decreased </em>eGFR can be obtained by calculating reciprocal of the listed HR.…”

Novelty and Primacy: A Long-Term Estimator for Online Experiments by Soheil Sadeghi (1538746)

“…However, since experiments are typically limited in duration, observed treatment effects are not always stable, sometimes revealing increasing or decreasing patterns over time. There are multiple causes for a treatment effect to change over time. …”

Data_Sheet_1_Antibacterial and anti-biofilm activity of diarylureas against Enterococcus faecium by suppressing the gene expression of peptidoglycan hydrolases and adherence.PDF by Yunfeng Xie (11437128)

“…Moreover, ZJ-2 can be docked into SagA to inhibit daughter cell separation. In a mouse model of abdominal infection, ZJ-2 decreased the bacterial load and the level of IL-6 and TNF-α in a time-dependent manner. …”

Evaluating competitive inhibition by gcn5-F221A using a synthetic pPHO5-yECitrine construct. by Amanda M. Lanza (168454)

“…Increasing expression of <i>gcn5-F221A</i> resulted in decreased mean fluorescence. …”

MiR-27a Functions as a Tumor Suppressor in Acute Leukemia by Regulating 14-3-3θ by Kara A. Scheibner (113934)

“…Decreased miR-23a cluster expression in some acute leukemia cell lines was mediated by c-MYC. …”

Image_5_LaeA Controls Virulence and Secondary Metabolism in Apple Canker Pathogen Valsa mali.TIF by Yaqiong Feng (9604034)

“…Toxicity tests proved that toxicity of secondary metabolites (SMs) produced by VmLaeA deletion mutant (ΔVmlaeA) was markedly decreased in comparison with wild-type (WT). …”

Image 3_A novel dual DYRK1A/B inhibitor for the treatment of type 1 diabetes.jpeg by Šarūnas Tumas (22419055)

“…</p>Results<p>Pharmacokinetic analysis confirmed the oral bioavailability of FX8474, and treatment was associated with improved fasted glucose levels and glucose tolerance after a 7-day treatment. Immunophenotyping indicated that FX8474 treatment increases CD4+ memory T cell populations while decreasing CD4+ effector cells, as well as restores CD8+ T cell phenotypes to levels observed in healthy mice.…”

Image_4_LaeA Controls Virulence and Secondary Metabolism in Apple Canker Pathogen Valsa mali.TIF by Yaqiong Feng (9604034)

“…Toxicity tests proved that toxicity of secondary metabolites (SMs) produced by VmLaeA deletion mutant (ΔVmlaeA) was markedly decreased in comparison with wild-type (WT). …”

Image 5_A novel dual DYRK1A/B inhibitor for the treatment of type 1 diabetes.jpeg by Šarūnas Tumas (22419055)

“…</p>Results<p>Pharmacokinetic analysis confirmed the oral bioavailability of FX8474, and treatment was associated with improved fasted glucose levels and glucose tolerance after a 7-day treatment. Immunophenotyping indicated that FX8474 treatment increases CD4+ memory T cell populations while decreasing CD4+ effector cells, as well as restores CD8+ T cell phenotypes to levels observed in healthy mice.…”

Image_7_LaeA Controls Virulence and Secondary Metabolism in Apple Canker Pathogen Valsa mali.TIF by Yaqiong Feng (9604034)

“…Toxicity tests proved that toxicity of secondary metabolites (SMs) produced by VmLaeA deletion mutant (ΔVmlaeA) was markedly decreased in comparison with wild-type (WT). …”

Data_Sheet_1_Major primary bile salts repress Salmonella enterica serovar Typhimurium invasiveness partly via the efflux regulatory locus ramRA.PDF by Etienne Giraud (122065)

“…Previous studies reported that bile inhibits the RamR binding to the ramA promoter, resulting in ramA increased transcription, and that ramA overexpression is associated to decreased expression of type III secretion system 1 (TTSS-1) invasion genes and to impaired intestinal cell invasiveness in S. …”

Table 2_Clinical features and genetic analysis of acrodermatitis enteropathica in an ethnic minority infant from Western China: a case report and literature review.xlsx by Tuerhongjiang Axirejiang (22346272)

“…Her serum zinc level significantly decreased (0.19 mg/L). Whole-exome sequencing revealed a homozygous c.197G > T(p. …”

Table_3_BcMettl4-Mediated DNA Adenine N6-Methylation Is Critical for Virulence of Botrytis cinerea.XLSX by Zhengang Miao (8262354)

“…Knockout of BcFDH led to reduced sclerotium formation, while disruption of BcMFS2 resulted in dramatically decreased conidium formation and pathogenicity. These observations indicated that 6mA provides potential epigenetic markers in B. cinerea and that BcMettl4 regulates virulence in this important plant pathogen.…”

Image 1_A novel dual DYRK1A/B inhibitor for the treatment of type 1 diabetes.tiff by Šarūnas Tumas (22419055)

“…</p>Results<p>Pharmacokinetic analysis confirmed the oral bioavailability of FX8474, and treatment was associated with improved fasted glucose levels and glucose tolerance after a 7-day treatment. Immunophenotyping indicated that FX8474 treatment increases CD4+ memory T cell populations while decreasing CD4+ effector cells, as well as restores CD8+ T cell phenotypes to levels observed in healthy mice.…”

Table_1_LaeA Controls Virulence and Secondary Metabolism in Apple Canker Pathogen Valsa mali.docx by Yaqiong Feng (9604034)

“…Toxicity tests proved that toxicity of secondary metabolites (SMs) produced by VmLaeA deletion mutant (ΔVmlaeA) was markedly decreased in comparison with wild-type (WT). …”

Image_2_BcMettl4-Mediated DNA Adenine N6-Methylation Is Critical for Virulence of Botrytis cinerea.TIF by Zhengang Miao (8262354)

“…Knockout of BcFDH led to reduced sclerotium formation, while disruption of BcMFS2 resulted in dramatically decreased conidium formation and pathogenicity. These observations indicated that 6mA provides potential epigenetic markers in B. cinerea and that BcMettl4 regulates virulence in this important plant pathogen.…”

Reciprocal Regulation of Annexin A2 and EGFR with Her-2 in Her-2 Negative and Herceptin-Resistant Breast Cancer by Praveenkumar K. Shetty (139121)

“…This effect was consistent in Herceptin resistant JIMT-1 cells as well as in Her-2 negative breast cancer. The siRNA mediated AnxA2 downregulation leads to increased apoptosis, decreased cell viability and migration. …”