DataSheet_2_Green tea extract suppresses airway inflammation via oxidative stress-driven MAPKs/MMP-9 signaling in asthmatic mice and human airway epithelial cells.zip by Jeong-Won Kim (18464976)

“…</p>Results<p>The GTE100 and GTE400 groups showed a decrease in airway hyperresponsiveness and the number of inflammatory cells in the bronchoalveolar lavage fluid (BALF) compared to the OVA group. …”

Image_1_Radiofrequency ablation plays double role in immunosuppression and activation of PBMCs in recurrent hepatocellular carcinoma.tif by Yang Zhao (39052)

“…The down-regulation of GZMB, GZMH, GZMK, and CD8A, which are involved in the cytotoxic function of T cells, was observed following RFA. …”

Image 2_The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI.tif by Rida Rehman (11120838)

“…We have previously demonstrated that several members of the Fibroblast Growth Factor Receptor (FGFR) family are transiently phosporylated upon TBI; the availability for drug repurposing of FGFR inhibitors makes worthwhile the elucidation of the role of FGFR in the acute phases of the response to TBI and the effect of FGFR inhibition.</p>Methods<p>A closed, blunt, weight-drop mild TBI protocol was employed. …”

OTX fusions influence the activity of the <i>Ci-pitx cis</i>-regulatory element. by Maximilian Haeussler (86348)

“…<p>Co-electroporation of <i>Pitx</i> full length distal region (pDistal<i>Pitx</i>:lacZ, 5.3kb, containing D1), respectively with pSix3:Venus (control), with pSix3>OTX_HD::enR (dominant negative OTX) and pSix3>OTX_HD::VP16 (hyper-active OTX). (A) Side view of an embryo co-electroporated with pDistal<i>Pitx</i>:lacZ and pSix3:Venus. …”

Data_Sheet_1_Impacts of eutrophication on microbial community structure in sediment, seawater, and phyllosphere of seagrass ecosystems.docx by Wenchao Deng (2826569)

“…Introduction<p>Seagrass-associated microbial communities play a crucial role in the growth and health of seagrasses. …”

Image_1_Cytotoxicity of InP/ZnS Quantum Dots With Different Surface Functional Groups Toward Two Lung-Derived Cell Lines.TIF by Ting Chen (15205)

“…<p>Although InP/ZnS quantum dots (QDs) have emerged as a presumably less hazardous alternative to cadmium-based QDs, their toxicity has not been fully understood. …”

<i>In Vivo</i> Effects of Pichia Pastoris-Expressed Antimicrobial Peptide Hepcidin on the Community Composition and Metabolism Gut Microbiota of Rats by Lanfang Tian (3234513)

“…However their <i>in vivo</i> effects on gut microbiota and gut health of hosts remain unclear. Here we performed a safety study of hepcidin so that it can be used to reduce microbial contaminations in the food and feed. …”

Image_4_The Global, Regional, and National Burden and Trends of Breast Cancer From 1990 to 2019: Results From the Global Burden of Disease Study 2019.tif by Shangbo Xu (10841163)

“…High social-development index (SDI) quintiles had the highest incidence cases with a declining trend in age-standardized incidence rate. …”

Ceftriaxone- and N-acetylcysteine-induced brain tolerance to ischemia: Influence on glutamate levels in focal cerebral ischemia by Weronika Krzyżanowska (4521394)

“…The results of immunofluorescence staining of GLT-1 and xCT on astrocytes, neurons and microglia accounted for the observed changes in extracellular Glu levels to a certain extent. Briefly, after MCAO, the expression of GLT-1 on astrocytes decreased, but pretreatment with CEF seemed to prevent this downregulation. …”

Table_3_Mucosal-Associated Invariant T Cell Features and TCR Repertoire Characteristics During the Course of Multiple Sclerosis.docx by Edgar Carnero Contentti (7900313)

“…These findings may contribute to a better understanding of pathophysiological phenomena underlying the course of MS, and discovery of MAIT cell inhibitors could pave the way for the development of new therapeutic strategies.…”

Image_1_Progressive Skeletal Muscle Loss After Surgery and Adjuvant Radiotherapy Impact Survival Outcomes in Patients With Early Stage Cervical Cancer.TIF by Jie Lee (6738179)

“…Skeletal muscle changes were measured using computed tomography scans at baseline, at simulation for radiotherapy, and at 3 months post-treatment. A decrease of ≥5% in the skeletal muscle was defined as “muscle loss.” …”

Assessing endocrine and immune parameters in human immunodeficiency virus-infected patients before and after the immune reconstitution inflammatory syndrome by Liliana Rateni (5138855)

“…Conclusion These parameters could contribute to differentiate IRIS-P from non-IRIS-P. The significant decrease in DHEA-S levels in IRIS-P after ART might suggest a different adrenal response in these patients, which may reflect the severity of the disease.…”

DataSheet1_Deciphering the Underlying Mechanisms of Formula Le-Cao-Shi Against Liver Injuries by Integrating Network Pharmacology, Metabonomics, and Experimental Validation.doc by Qing Zhao (170569)

“…<p>Le-Cao-Shi (LCS) has long been used as a folk traditional Chinese medicine formula against liver injuries, whereas its pharmacological mechanisms remain elusive. …”

Image_2_The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki disease.tif by Fangyan Wang (6410591)

“…In vitro, butyrate, not acetate or propionate, increased the expression of phosphatase MKP-1 to dephosphorylate activated JNK, ERK1/2 and p38 MAPK against excessive inflammation in RAW264.7 macrophages. It suggests a new insight into probiotics and their metabolites supplements to treat KD.…”

Histological and ultrastructural alterations in diabetic VASH2 knockout mice. by Kana Masuda (634768)

“…<p>(A) Representative light microscopic images of glomeruli from non-diabetic wild-type, non-diabetic VASH2 knockout, diabetic wild-type, and diabetic VASH2 knockout mice (periodic acid-Schiff staining, original magnification, ×400). …”

T2’-Imaging to Assess Cerebral Oxygen Extraction Fraction in Carotid Occlusive Disease: Influence of Cerebral Autoregulation and Cerebral Blood Volume by Alexander Seiler (3080283)

“…<div><p>Purpose</p><p>Quantitative T2'-mapping detects regional changes of the relation of oxygenated and deoxygenated hemoglobin (Hb) by using their different magnetic properties in gradient echo imaging and might therefore be a surrogate marker of increased oxygen extraction fraction (OEF) in cerebral hypoperfusion. …”

Table_2_The Impact of Particulate Matter (PM2.5) on Human Retinal Development in hESC-Derived Retinal Organoids.XLSX by Yuxiao Zeng (770249)

“…It demonstrated that the formation rate of the hERO-derived neural retina (NR) was affected by PM2.5 in a concentration dosage-dependent manner. The areas of hEROs and the thickness of hERO-NRs were significantly reduced after PM2.5 exposure at the concentration of 25, 50, and 100 μg/ml, which was due to the decrease of proliferation and the increase of apoptosis. …”

Image_4_Differential Action of Reelin on Oligomerization of ApoER2 and VLDL Receptor in HEK293 Cells Assessed by Time-Resolved Anisotropy and Fluorescence Lifetime Imaging Microsco... by Paula Dlugosz (6400175)

“…Details of this pathway are still not fully understood since the participating components are highly variable and create a complex mixture of interacting molecules. Reelin is proteolytically processed resulting in five different fragments some of which carrying the binding site for two different but highly homologous receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR). …”

Image_5_Transcriptome Profiling of the Elongating Internode of Cotton (Gossypium hirsutum L.) Seedlings in Response to Mepiquat Chloride.jpg by Li Wang (15202)

“…In summary, we confirmed the important role of GA in MC-induced growth inhibition of cotton, and further found that other hormones were also involved in this process in a GA-dependent manner. This study provides novel insights into the molecular mechanism underlying the MC-mediated inhibition of internode elongation in cotton seedlings.…”

Supplementary material: Evaluation of emerging NASH therapies: the impact of treatment efficacy profiles on long-term health outcomes by William Herring (18495130)

“…<b>Materials & methods:</b> A Markov model with NASH fibrosis stages F0–F3, NASH resolution, compensated cirrhosis (F4/CC), and liver-related complication (LRC) states was developed using literature-based standard of care (SoC) data. …”