Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer by Robert J. Cardnell (2602669)

“…Global ATP concentrations increased following PARP inhibition (p≤0.02) leading us to hypothesize that the observed increased PI3K/mTOR pathway activation following PARP inhibition results from decreased ATP usage and a subsequent decrease in stress response signaling via LKB1. …”

S1 Data - by Syed Salman Shahid (16625097)

“…In this study, CEST and short echo time single voxel MRS was performed to evaluate the sensitivity of cerebral metabolites to beta-amyloid (Aβ) induced synaptic deficit in the hippocampus of a mouse model of Alzheimer’s disease. …”

Transcriptome and physiology analysis reveal key players of the shade-tolerant species <i>Panax notoginseng</i> in photosynthetic performance under both high and low light regimes by Jin-Yan Zhang (9037088)

“…<p>The present study aimed to understand the molecular mechanism underlying the light-induced depression of photosynthetic capacity in a typically shade-tolerant species <i>Panax notoginseng</i> grown under different light intensities. …”

Image_1_The Effect of Metaphylactic Use of Tildipirosin for the Control of Respiratory Disease in Long-Distance Transported Dairy Calves.pdf by Maria Luiza Celestino (9352070)

“…At 27 days after enrollment, META2 calves had decreased concentrations of haptoglobin, serum amyloid A, and aspartate aminotransferase, compared to CON calves (P < 0.05). …”

Image 3_The global burden of neonatal sepsis attributable to air pollution from 1990 to 2021: findings from the global burden of disease study 2021.jpeg by Jiajia Duan (9351878)

“…</p>Result<p>In 2021, global deaths from neonatal sepsis and related infections attributable to air pollution numbered 54,026 (95% UI: 45,371–64,084), a 23.48% decrease from 1990, with age-standardized death rates dropping 1.49% annually (EAPC = −1.49). …”

<i>tll</i> is required for primary PR precursor cell fate. by Abhishek Kumar Mishra (502194)

“…Svp-positive secondary PR precursors are also reduced (D’) potentially as a result of the decrease in the number of primary PR precursors (B’); Maximum intensity projections of confocal sections. …”

Image_1_Exploring candidate biomarkers for rheumatoid arthritis through cardiovascular and cardiometabolic serum proteome profiling.tiff by Laura Cuesta-López (17963900)

“…These reductions were associated with a decrease in DAS28. Baseline levels of SAA4 and high levels of BNP were associated to the non-response to methotrexate. …”

FOXG1 interaction with SATB2 promotes autophagy to alleviate neuroinflammation and mechanical abnormal pain in rats with lumbar disc herniation by Zhanchao Wang (779221)

“…TNF-α induced an increase in p62 protein and a decrease in LC3II/I and Beclin-1 proteins in neurons, which were blocked by oe-FOXG1. oe-FOXG1 suppressed inflammation and apoptosis in TNF-α-induced DRG neurons and LDH rats and promoted the expression of Cyclin D1, PCNA, and Ki67. …”

DataSheet2_Age influence on resistance and deformation of the human sutured meniscal horn in the immediate postoperative period.pdf by Alejandro Peña-Trabalon (17738835)

“…<p>Introduction: To preserve knee function, surgical repair is indicated when a meniscal root disinsertion occurs. However, this surgery has not yet achieved complete recovery of the joint´s natural biomechanics, with the meniscus-suture interface identified as a potentially determining factor. …”

Sleep-enhancement in males due to pair-wise social interaction. by Shahnaz Rahman Lone (191710)

“…Although nighttime sleep latency also shows a similar decrease, it did not reach statistically significant levels (<i>p</i> > 0.05, Student’s <i>t</i>-test). …”

Image3_Combined effect of traditional Chinese herbal-based formulations Jing Si herbal tea and Jing Si nasal drop inhibits adhesion and transmission of SARS-CoV2 in diabetic SKH-1... by Chien-Yi Chiang (344057)

“…The results showed that both JHT and JND were effective in alleviating the viral entry and accumulation in the thorax and the abdominal area. While JHT showed a dose-dependent decrease in the viral load, JND showed early inhibition of viral entry from day 1 of the infection. …”

Data_Sheet_1_Immediate and Delayed Response of Simulated Human Atrial Myocytes to Clinically-Relevant Hypokalemia.PDF by Michael Clerx (4517584)

“…A progressive shift in intracellular [Na⁺]_i causes a change in the outward electrogenic current generated by the Na⁺/K⁺ pump, thereby modifying V_r and AP repolarization and changing the human atrial electrophysiological substrate.…”

Data_Sheet_1_Adherence to COVID-19 preventive measures in Sub-Saharan Africa during the 1st year of the pandemic: Pooled analysis of the International Citizen Project on COVID-19 (... by Leonard Ngarka (6036032)

“…</p>Conclusion<p>Decreasing adherence to non-pharmaceutical measures over time constitutes a risk for the persistence of COVID-19 in SSA. …”

Carbon starvation regulatory pathways. by Leticia Britos (225008)

“…CtrA activation or repression was inferred by the direction of the change observed upon starvation: those genes with increased transcript levels upon starvation were inferred to be negatively regulated by CtrA (and consequently derepressed as CtrA protein levels decrease upon starvation); genes with decreased transcript levels were inferred to be positively regulated by CtrA. …”

Image_2_Combined Effect of CYP2C19 Genetic Polymorphisms and C-Reactive Protein on Voriconazole Exposure and Dosing in Immunocompromised Children.JPEG by Juan Chen (61123)

“…Covariates associated with voriconazole plasma concentrations and dose requirements were adjusted by using generalized linear mixed-effect models.</p>Results<p>A total of 682 voriconazole steady-state trough concentrations from 91 Chinese pediatric patients were included. …”

Table_1_Association of metabolic dysfunction-associated fatty liver disease, type 2 diabetes mellitus, and metabolic goal achievement with risk of chronic kidney disease.docx by Weitao Su (4636516)

“…</p>Results<p>The MAFLD group had a higher prevalence of CKD (16.2 vs. 7.6%, P < 0.001) than the non-MAFLD group. …”

Image_1_Combined Effect of CYP2C19 Genetic Polymorphisms and C-Reactive Protein on Voriconazole Exposure and Dosing in Immunocompromised Children.JPEG by Juan Chen (61123)

“…Covariates associated with voriconazole plasma concentrations and dose requirements were adjusted by using generalized linear mixed-effect models.</p>Results<p>A total of 682 voriconazole steady-state trough concentrations from 91 Chinese pediatric patients were included. …”

2010 | Assessing the subjective effects of antipsychotic treatment in the daily life of patients with schizophrenia: Implementing the Experience Sampling Method in psychopharmacolo... by Johan Lataster (4447606)

“…</div><div>In the remaining group of patients, switching to aripiprazole treatment was accompanied by a decrease in psychotic symptoms, but als decreased feelings of positive and negative affect in daily life.…”

DataSheet1_Characterization of Polymer Degrading Lipases, LIP1 and LIP2 From Pseudomonas chlororaphis PA23.PDF by Nisha Mohanan (12433623)

“…Gel Permeation Chromatography (GPC) analysis showed a decrease in the molecular weight of the polymers after incubation with LIP1 and LIP2. …”

Association of favipiravir with outcomes. by Martin Modrák (5101439)

“…The “Suspicious” section shows models that were found to not fit the data well or have computational issues—see supplementary statistical analysis for details. Each row represents a model—Categorical All/7/28 = Bayesian categorical regression for state at last observed day/day 7/day 28, Binary All/7/28 = Bayesian logistic regression for state at last observed day/day 7/day 28, Bayes Cox = Bayesian version of the Cox proportional hazards model with a binary outcome, Cox (single) = frequentist Cox model with a binary outcome, Cox (competing) = frequentist Cox model using competing risks (as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0245103#pone.0245103.g001" target="_blank">Fig 1a</a>), HMM A = Bayesian hidden-Markov model as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0245103#pone.0245103.g001" target="_blank">Fig 1b</a> with predictors for rate groups, HMM B = Bayesian hidden-markov model as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0245103#pone.0245103.g001" target="_blank">Fig 1b</a> with predictors for individual rates, HMM C = Bayesian hidden-Markov model as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0245103#pone.0245103.g001" target="_blank">Fig 1c</a>. …”