Overexpression of HTRA1 Leads to Down-Regulation of Fibronectin and Functional Changes in RF/6A Cells and HUVECs by Jingjing Jiang (128923)

“…Fibronectin mRNA and protein levels were significantly down-regulated following the upregulation of HTRA1, whereas the expressions of laminin, VEGF and MMP-2 were unaffected by alterations in HTRA1 expression. The decreased biological function of vascular endothelial cells and the degradation of extracellular matrix proteins, such as fibronectin, may be involved in a contributory role for HTRA1 in PCV pathogenesis.…”

In vivo analysis of the δ-GABA_A-Rs in the cerebellar granule layer in WT and TTR-/- mice. by Li Zhou (54356)

“…The total δ protein level showed no difference, while the biotinylated surface δ protein level decreased significantly in TTR-/- mice. Both total and the surface γ2 GABA_A-Rs have no difference between WT and TTR-/- mice. …”

Morbidity and mortality in Holstein calves from birth to 145 days of age on a large dairy farm in Brazil by V. Gomes (4770210)

“…<div><p>ABSTRACT The present study aimed to investigate the morbidity and mortality associated with the most common diseases during the rearing period of Holstein calves in a high-production dairy farm. The calves (n = 600) were allocated to three groups based on age: G1 (1-7 days, n = 216), G2 (30-40 days, n = 188), and G3 (69-85 days, n = 196). …”

Vesicular glutamate transporters play a role in neuronal differentiation of cultured SVZ-derived neural precursor cells by Eduardo H. Sánchez-Mendoza (4020176)

Image_2_Case Report: Mature Plasmacytoid Dendritic Cell Proliferation Associated With a Lymphoid Neoplasm.tiff by Fei Fei (794241)

“…Analysis of the pDC frequency in a separate cohort of T-ALL and control patients demonstrated that bone marrow pDCs are often decreased in patients with T-ALL compared to controls. …”

Oral mucosa transplantation may improve tear film osmolarity in dogs with keratoconjunctivitis sicca - a preliminary study by F.L.C. Brito (12739237)

“…There was a decreased osmolarity in both groups after treatment. …”

Image4_Functional analysis of a first hindlimb positioning enhancer via Gdf11 expression.TIF by Seiji Saito (502436)

Comparison of expression pattern with previous studies by (Hatzirodos <i>et al</i>.(a, b)) [30, 31]. by Gianluca Mazzoni (3922064)

“…(<b>b</b>) Explanation of the comparisons. A gene is considered to have the same trend when its expression decreases or increases in both the studies for each comparison. …”

Biomarker repurposing: Therapeutic drug monitoring of serum theophylline offers a potential diagnostic biomarker of Parkinson’s disease by Takuma Ohmichi (718120)

“…<div><p>Caffeine has been considered a neuroprotective agent against Parkinson’s disease (PD). …”

Table_1_A Novel Resveratrol Analog Upregulates SIRT1 Expression and Ameliorates Neointima Formation.DOCX by Baohui Yuan (11633554)

“…<p>Neointima formation is a serious complication caused by mechanical trauma to the vessel. …”

Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells by Mariana Costa Braga Schmidt (5777168)

“…In the present report, we provide a mechanistic insight to these antitumor effects, this is,  Amblyomin-X modulates Rho-GTPases and uPAR signaling, and reduces the release of MMPs, leading to disruption of the actin cytoskeleton and decreased cell migration of tumor cell lines. …”

Trapping Lithium into Hollow Silica Microspheres with a Carbon Nanotube Core for Dendrite-Free Lithium Metal Anodes by Tong-Tong Zuo (4571260)

“…Li metal anodes, which have attracted much attention for their high specific capacity and low redox potential, face a great challenge in realizing their practical application. …”

The intrinsic fluctuations follow a binomial distribution and can maximize their variance away from the threshold of the response curve. by Bruno M.C. Martins (340291)

“…<p>(<b>A</b>) Comparison between Eq. (5) (in dark blue) and numerical simulation (red line). …”

Table_1_Identification and characterization of a novel gene involved in glandular trichome development in Nepeta tenuifolia.XLSX by Peina Zhou (10995601)

“…Virus-induced gene silencing of NtMIXTA1 resulted in lower PGT density, a significant reduction in monoterpene concentration, and the decreased expression of genes related to monoterpene biosynthesis. …”

Theta Burst Stimulation of the Cerebellum Modifies the TMS-Evoked N100 Potential, a Marker of GABA Inhibition by Allanah Harrington (821303)

“…<div><p>Theta burst stimulation (TBS) of the cerebellum, a potential therapy for neurological disease, can modulate corticospinal excitability via the dentato-thalamo-cortical pathway, but it is uncertain whether its effects are mediated via inhibitory or facilitatory networks. …”

Methylophiopogonanone A, an Ophiopogon homoisoflavonoid, alleviates high-fat diet-induced hyperlipidemia: assessment of its potential mechanism by Zhao Li (300229)

“…In HFD-induced rats, pretreatment with MO-A decreased the body weight gain and reduced serum and hepatic lipid levels. …”

Image3_m6A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement.TIFF by Wenzheng Qu (11617021)

“…Notably, EE exposure decreased the protein level of m⁶A eraser Fto, but did not affect the protein level of m⁶A writers METTL3 and METTL14. …”

Supplementary Material for: Evaluation of a novel combination therapy, based on trifluridine/tipiracil and fruquintinib, against colorectal cancer by Nukatsuka M. (14349846)

“…Its major mechanism of action is the dysfunction of tumoral DNA including DNA strand breaks and decreased replication. Fruquintinib (ELUNATE®) is a novel kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-1, -2, and -3. …”

Datasheet2_Case report: Muscle involvement in a Chinese patient with TRNT1-related disorder.pdf by Cui-Jie Wei (7364762)

“…Whole-exome sequencing revealed compound heterozygous variants of the TRNT1 gene, c.443C > T (p.Ala148Val) and c.692C > G (p.Ala231Gly), in the patient. Western blot showed a decreased expression of TRNT1 and cytochrome c oxidase subunit IV (COX IV) in the skeletal muscle of the patient. …”

Table2_m6A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement.XLSX by Wenzheng Qu (11617021)

“…Notably, EE exposure decreased the protein level of m⁶A eraser Fto, but did not affect the protein level of m⁶A writers METTL3 and METTL14. …”