Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action by Christopher J. Zerio (11595690)

“…A medicinal chemistry campaign produced the novel eIF4A inhibitor <b>28</b>, which decreased BJAB Burkitt lymphoma cell viability. …”

Persistent decrease in dendritic excitability following paired stimulation. by Anna Labno (505791)

“…When no stimulation was applied (top) no change in dendritic excitability is observed, however after paired stimulation (bottom) excitability decreased (<b>D</b>) Dendritic excitability prior to paired stimulation, shows a steady basal level of dendritic excitability as assessed by measuring the peak magnitude of the ChR2-induced photo current. …”

Tom clone number and area decrease during pupariation. by Jeremy Brown (3311742)

Structural Basis for Sequence Specific DNA Binding and Protein Dimerization of HOXA13 by Yonghong Zhang (20918)

“…I366 makes similar methyl contacts with T3* and T4*. Mutants (I366A, N370A and V373G) all have decreased DNA binding and transcriptional activity. …”

Foldases and holdases each decrease the level of unfolded protein. by Adam MR de Graff (9767829)

Phosphosite mutations in Hcm1 decrease fitness in stress. by Michelle M. Conti (13514386)

<i>Cotton Leaf Curl Multan virus</i> C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase by Asigul Ismayil (5698946)

“…Plants infected with CLCuMuV carrying C4^R13A show decreased levels of symptoms and viral DNA accumulation associated with enhanced viral DNA methylation. …”

The multicopy sRNA LhrC controls expression of the oligopeptide-binding protein OppA in <i>Listeria monocytogenes</i> by Susanne Sievers (256439)

“…For OppA, we show that LhrC acts by direct base paring to the ribosome binding site of the <i>oppA</i> mRNA, leading to an impediment of its translation and a decreased mRNA level. …”

A R13A point mutation in C4 attenuates CLCuMuV infection. by Asigul Ismayil (5698946)

“…<b>(C)</b> The mutant CLCuMuV carrying C4^R13A (CLCuMuV-C4^R13A), which contains a R13A mutation in <i>C4</i>, showed the decreased viral symptom compared to wild type CLCuMuV. …”

Induction of immunomodulatory miR-146a and miR-155 in small intestinal epithelium of <i>Vibrio cholerae</i> infected patients at acute stage of cholera by Aziz Bitar (257322)

“…Only marginal down-regulation of target genes IRAK1 and CARD10 was seen and a weak cytokine-profile was identified in the acute infected mucosa. …”

Decrease of tumor perfusion following anti-angiogenic therapy. by Philipp M. Kazmierczak (465021)

Glucose and statins decrease cholesterol efflux from macrophages. by Wei-Ming Chen (560699)

ECoG timescales decrease during spatial attention. by Isabel Raposo (21615517)

“…<p><b>(A)</b> Top: behavioral timescales do not differ between different groups of participants (exp. 1 and 3/4) doing the same task; Bottom: Illustration of ECoG electrode placement for all subjects for both two location (left) and four location (right) tasks for the frontal, motor and parietal regions. …”

SNPs may increase or decrease affinity of RE1s. by Rory Johnson (172986)

“…<p>Examples of SNPs that decrease (A) and increase (B) the affinity of an RE1 sequence. …”

Ibuprofen and diclofenac decrease lactate levels and LDH activity. by Verena Leidgens (815986)

“…Diclofenac treatment resulted in a significant decrease of lactate at all concentrations and in all cell lines. …”

Vinpocetine inhibits carrageenan-induced decrease in antioxidant capacity. by Kenji W. Ruiz-Miyazawa (714809)

Protease-Resistant Prions Selectively Decrease Shadoo Protein by Joel C. Watts (195735)

“…To test this hypothesis, we examined levels of Sho during prion infection using a variety of experimental systems. Sho protein levels were decreased in the brains of mice, hamsters, voles, and sheep infected with different natural and experimental prion strains. …”

Decrease in the use of emotion-related words through time. by Alberto Acerbi (61063)

Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca²⁺ waves by Norma Leticia Gómez-Viquez (10285471)

“…We hypothesised that OS decreases RyR2/SERCA2a activity at early MetS, and while decreased SERCA2a favours CaW propagation, diminished RyR2 restrains it.…”

Decrease in VACV infectivity linked to defect in viral entry. by Lalita Priyamvada (421536)