Visualization of the baseline (WT) and <i>Tsc1</i> null (KO) results within a smooth muscle cell phenotypic space bounded by vertices defined as purely contractile (1.0), purely sy... by Ana C. Estrada (8917370)

“…<p>The degree of a phenotype was calculated for each cell using the mean activation of a subset of relevant species: contractile {SMMHC, SMA, SM22}, synthetic {Col3a1, Eln, TIMP}, and degradative {LAMP1/2, MMP2, S6, MITF, and β-catenin}. a) As it can be seen, the simulated Baseline cell was primarily contractile-synthetic, with non-zero degradative, as expected of a normal cell performing a mechano-sensing and mechano-regulating function to maintain an extracellular matrix experiencing low turnover. b) A representative <i>Tsc1</i> KO cell exhibited a shift towards a degradative phenotype with decreases in the degree of contractile and synthetic phenotypic expression.…”

Leucocyte counts in alveoli and blood of ferrets inoculated with different influenza viruses. by Judith M. A. van den Brand (144343)

“…For pH1N1 there is a peak of neutrophils in the alveoli on 0.5 dpi followed by a dip and a response of myelopoiesis in the blood. …”

Plots of gene expression values for <i>SOX5</i>, <i>COL2A1</i>, <i>ELN</i>, <i>B2M</i>, <i>CASP8</i>, <i>CASP9</i>, and <i>IL1A</i> normalized to large ribosomal fraction, <i>P0</i... by Narihiko Hirano (11104945)

“…There were no significant differences between ethanol-treated and untreated constructs in gene expression of <i>B2M</i> (p = 0.187), <i>CASP8</i> (p = 0.737) or <i>CASP9</i> (p = 0.070) while <i>IL1A</i> was significantly decreased (*p = 0.040) (lower left panel). …”

Genetic diversity and haplotype homozygosity in the M and S molecular forms at the <i>APL1</i> locus and flanking regions are indicative of selective maintenance of diversity at <i... by Susan M. Rottschaefer (228046)

“…<p>Nucleotide diversity (π) at <i>APL1</i> is greatly reduced in the M form relative to the S form with a strong skew toward rare variants (indicated by negative values of <i>F</i>*) that is not observed in the S form (see also <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000600#pbio-1000600-g004" target="_blank">Figure 4</a>). …”

The effect of the genetic deletion of P2rx7 on ATP-evoked tritiated (A, C) and endogenous (B) glutamate efflux (D) mRNA expression and (E–I) immunofluorescence staining of the NR2B... by Cecilia Csölle (425362)

“…After a 60-min preperfusion, the basal extracellular [³H]Glu efflux was lower in P2rx7−/− mice. 6-min perfusion of ATP (10 mM) resulted in a transient increase in the efflux of [³H]Glu in P2rx7+/+ mice, which peaked at 6 min after ATP administration and gradually decreased to baseline levels after 12 min. …”

Results from Random Forest classification of the different rejection groups (ISO, TAC, ATC) using over the whole time course (POD 3, POD 5, POD 7, POD 9) measured inflammatory medi... by Dolores Wolfram (577814)

Spatial structure of precipitation anomaly trend (left column) and trend difference relating to changes in precipitation intensity distribution (right column) from ((a), (e)) GPCP,... by Chunlei Liu (57542)

“…</strong> Spatial structure of precipitation anomaly trend (left column) and trend difference relating to changes in precipitation intensity distribution (right column) from ((a), (e)) GPCP, ((b), (f)) AMIP5, ((c), (g)) CMIP historical and ((d), (h)) RCP 4.5 data sets. …”

DataSheet_1_Gene expression profiling indicates a shift in ammonia assimilation capacity along the hepatic acinus induced by different forms of selenium in vitamin–mineral mixes fe... by Yang Jia (5846711)

“…In addition, MIX and OSe steers had a higher capacity for pericentral ammonia assimilation (higher glutamine synthetase activity) and a higher capacity for the production of glutamate in pericentral hepatocytes from α-ketoglutarate (higher levels of glutamine dehydrogenase, and decreased levels of arginase 2 and ornithine aminotransferase and mRNA). …”

Relative glucose in cell culture media that incubated primary bovine neonatal hepatocytes exposed to increasing concentrations of choline chloride (CC) and D,L-Met (DLM) for 24 h,... by Tawny L. Chandler (3713197)

Supplementary Figure S1: Name and location of the 27 electrodes projected onto a 2D surface used in the current study. Electrode position is at the center of the label. from Global... by Peter Achermann (20801)

“…Compared to NREM sleep, REM sleep showed larger GFS values in all frequencies except in the spindle and theta bands, where NREM sleep showed a peak in GFS. …”

Table_1_Changes in the consumption of isoflavones, omega-6, and omega-3 fatty acids in women with metastatic breast cancer adopting a whole-food, plant-based diet: post-hoc analysi... by Jean Lee (2561902)

“…Within the WFPB group, linoleic acid (n-6 PUFA) consumption decreased by a mean of 3.8 g (p = 0.0095), from 12.8 g/day to 9.0 g/day; total n-3 PUFA consumption increased by a mean of 1.1 g (p = 0.0005), from 1.6 g/day to 2.7 g/day.…”

(<i>ⁿ</i>Bu₄N)[Ni(dmstfdt)₂]:  A Planar Nickel Coordination Complex with an Extended-TTF Ligand Exhibiting Metallic Conduction, Metal−In... by Emiko Fujiwara (2108137)

“…The χ<i>T</i> values of <b>1</b> increase linearly from 0.129 to 0.383 emu K mol^-1 with decreasing temperature (160−340 K), suggesting a gradual electron localization with lowering the temperature. …”

(<i>ⁿ</i>Bu₄N)[Ni(dmstfdt)₂]:  A Planar Nickel Coordination Complex with an Extended-TTF Ligand Exhibiting Metallic Conduction, Metal−In... by Emiko Fujiwara (2108137)

“…The χ<i>T</i> values of <b>1</b> increase linearly from 0.129 to 0.383 emu K mol^-1 with decreasing temperature (160−340 K), suggesting a gradual electron localization with lowering the temperature. …”

Total fecal wet weight (A), % of fecal wet weight (%WW) (B), delta % fecal wet weight (Δ%WW) in interval I (C), delta % fecal wet weight (Δ%WW) in interval II (D), stool frequency... by Mojtaba Porbahaie (14341301)

“…The dotted lines represent challenges on day 14 and day 35 of the study, and each symbol represents the mean and SEM of the group. Data (A, B, E, and F) were analyzed using repeated-measures Generalized Estimating Equations (GEE) model and one-way ANOVA post-test was applied to check the linear trend the data in (C and D).…”

Hook-shaped dose-response curves for trappable and non-trappable blockers simulated using our modified version of the O’Hara-Rudy model of the undiseased human heart as a function... by Hongbin Wan (1904146)

“…The hERG safety margin should reside somewhere on the quasi-linear region of the corresponding curve (far from the tipping point) within a certain number of exposure doublings between the TFPC_max and tipping point, commensurate with the benefit/risk of the disease indication (zero hERG blockade at the TFPC_max is of course ideal). …”

A-E. The participants’ VAS pain scores, walking distance covered during the 6-Minute Walk Test, Short Form-12 sum scores and Western Ontario and McMaster Universities Osteoarthriti... by Lex D. de Jong (22138778)

“…^a Over time, participants from both groups showed a 28.9 (95% CI 4.4 to 53.3) increase in the distance covered during the 6-MWT, a negligible 0.06 change in Short Form-12 sum scores (95% CI −0.25 to 0.36) and a 7.6 (95% CI −13.8 to −1.35) decrease in WOMAC sum scores. 6-MWT, 6-Minute Walk Test; CI, confidence interval; VAS, Visual Analogue Scale; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.…”

Effect Of Oral Administration Of Alcohol On The Developing Rat Embryos by El Shabaka, H. A. [حمزة احمد الشبكة]

Get full text

Protein levels of Bcl-2 family markers in limbal stromal cells (LSCs) and in Aniridia-LSCs (AN-LSCs), after treatment with 0 µM, 50 µM and 75 µM Cobalt chloride (CoCl₂),... by Shanhe Liu (5251313)

DataSheet_1_Kinetics of vaccine-induced neutralizing antibody titers and estimated protective immunity against wild-type SARS-CoV-2 and the Delta variant: A prospective nationwide... by Eliel Nham (13847299)

“…A correlation equation was deduced between a PRNT 50% neutralizing dose (ND₅₀) against wild type (WT) SARS-CoV-2 and that of the Delta variant.…”

Quantitative image analysis metrics for the 3D gridded reconstruction (SIMBA) in red, the motion-resolved reconstruction (XD-SIMBA) in purple, the motion-resolved reconstruction wi... by Ludovica Romanin (18824043)

“…When looking at the relative percentage changes in image quality scores (IQS), overall XD-SIMBA results in a decrease in image quality score compared to SIMBA. …”