Upward and downward ramps in inferred spikes during reward approach in a virtual reality environment are detectable over a range of tuning parameters. by Weston Fleming (10924744)

“…For each tuning parameter, histograms of changes of the inferred firing rate slope for each neuron, color coded by whether a neuron’s probability of firing significantly decreased (red; mean slope = -0.09 spikes/s², n = 67/303 neurons for 4 Hz target; mean slope = -0.12 spikes/s², n = 72/303 neurons for 6 Hz target; mean slope = -0.15 spikes/s², n = 77/303 neurons for 8 Hz target), increased (blue; mean slope = 0.13 spikes/s², n = 102/303 neurons for 4 Hz target; mean slope = 0.18 spikes/s²; n = 112/303 neurons for 6 Hz target; mean slope = 0.22 spikes/s², n = 119/303 neurons for 8 Hz target), or did not change (grey; mean slope = 0.01 spikes/s², n = 134/303 neurons for 4 Hz target; mean slope = 0.02 spikes/s²; n = 119/303 neurons for 6 Hz target; mean slope = 0.02 spikes/s², n = 107/303 neurons for 8 Hz target) with increases in maze position. …”

<i>Rap1</i> knockin mice exhibit sex-dependent differences in immune responses. by Amanda J. Stock (3139719)

Lysosome function, as assessed by Lamp1 levels, are unchanged in the <i>GBA1</i> D409V KI mouse model. by Nicole K. Polinski (10947787)

The workflow of our proposed KBLTDARD model. by Yingjun Ma (1962334)

“…Compared to traditional biological experiments, computational models can not only save time and reduce costs, but also discover potential associations on a large scale. Although some computational models based on tensor decomposition have been proposed, these models usually require manual specification of numerous hyperparameters, leading to a decrease in computational efficiency and generalization ability. …”

The probability graph framework of KBLTDARD. by Yingjun Ma (1962334)

“…Compared to traditional biological experiments, computational models can not only save time and reduce costs, but also discover potential associations on a large scale. Although some computational models based on tensor decomposition have been proposed, these models usually require manual specification of numerous hyperparameters, leading to a decrease in computational efficiency and generalization ability. …”

Generation and life span of <i>Rap1</i> knockin mice. by Amanda J. Stock (3139719)

Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial by Piero Ruscitti (3684799)

“…Participants in the anakinra group had a significant reduction of HbA1c%, in an unadjusted linear mixed model, after 3 months (β: −0.85, <i>p</i> < 0.001, 95% CI −1.28 to −0.42) and 6 months (β: −1.05, <i>p</i> < 0.001, 95% CI −1.50 to −0.59). …”

Fold change in humoral and cellular response magnitudes from RV305 week 2 to week 26. by LaTonya D. Williams (3140490)

<i>E. coli</i> K1 binds to FcγRIa via OmpA and induces a distinct signaling. by Rahul Mittal (202639)

“…Competitive inhibition studies were performed at least four times in triplicate and the data represent mean ± SD. The decrease in the number of bacteria attached to COS-1 cells or MFI was statistically significant compared to IgG2a coated OmpA− <i>E. coli</i>, *p<0.001 by Student's <i>t</i> test.…”

Srp is required for amplification of adult fat body precursors (related to Figs 2 and 3). by Yuting Lei (9624598)

Social interaction involves CeA neurons. by Karolina Rojek-Sito (13197192)

“…Ctrl: Social cells: <i>n =</i> 7, Ctrl: Food cells: <i>n</i> = 7, Activation: Social cells: <i>n</i> = 7, Activation: Food cells: <i>n</i> = 9. CeA, central amygdala. All the data are shown as the mean ± SEM, and dots represent individual data points, * <i>p</i> < 0.05, ** <i>p</i> < 0.01, *** <i>p</i> < 0.001. …”

Loss of function mutations in essential genes cause embryonic lethality in pigs by Martijn F. L. Derks (5348063)

“…The lethal haplotypes have a large effect on carrier-by-carrier matings, decreasing litter sizes by 15.1 to 21.6%. …”

Upward and downward ramps in inferred spikes during reward approach in a virtual reality environment are detectable over a range of decay rates. by Weston Fleming (10924744)

“…For each decay rate, histograms of changes of the inferred firing rate slope for each neuron, color coded by whether a neuron’s probability of firing significantly decreased (red; mean slope = -0.12 spikes/s², n = 70/303 neurons for low gamma; mean slope = -0.12 spikes/s², n = 72/303 neurons for median gamma; mean slope = -0.14 spikes/s², n = 74/303 neurons for high gamma), increased (blue; mean slope = 0.18 spikes/s², n = 111/303 neurons for low gamma; mean slope = 0.18 spikes/s²; n = 112/303 neurons for median gamma; mean slope = 0.18 spikes/s², n = 117/303 neurons for high gamma), or did not change (grey; mean slope = 0.02 spikes/s², n = 122/303 neurons for low gamma; mean slope = 0.02 spikes/s²; n = 119/303 neurons for median gamma; mean slope = 0.01 spikes/s², n = 112/303 neurons for high gamma) with increases in maze position. …”

FGF signaling is required for adult adipogenesis. by Yuting Lei (9624598)

GCase substrate levels are altered in the brain and liver of homozygous <i>GBA1</i> D409V KI mice. by Nicole K. Polinski (10947787)

Slow gene control and heterochrony. by Takahiro Kohsokabe (18078713)

Dopamine turnover, but not total dopamine levels or nigral dopamine neuron numbers, are altered in aged homozygous <i>GBA1</i> D409V KI mice as compared to controls. by Nicole K. Polinski (10947787)

Photomanipulation of the CeA social and food cells. by Karolina Rojek-Sito (13197192)

“…The control group had the social interaction after a brief, 10-minute separation (Ctrl) <b>(B)</b> Representative image of c-Fos expression in the CeA in the SI group (lower magnification of the image shown in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002343#pbio.3002343.g001" target="_blank">Fig 1C</a>). …”

Introduction of the D409V point mutation to the <i>GBA1</i> gene does not affect <i>GBA1</i> mRNA transcription or GCase protein translation. by Nicole K. Polinski (10947787)

The H520 cell line lacks adherens junctions and expresses EMT traits. by Jaileene Pérez-Morales (5988131)

“…In contrast, E-cadherin expression is notably decreased in H520 cells in a diffuse cytoplasmic staining pattern. …”