DataSheet_1_GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis.pdf by Xiaomiao Ye (13850284)

“…Moreover, compared with WT mice, GSDMD^-/- mice showed reduced infarct size (25.45 ± 3.07% versus 36.47 ± 3.72%), improved left ventricular ejection fraction (37.71 ± 1.81% versus 29.44 ± 2.28%) and left ventricular fractional shortening (18.01 ± 0.97% versus 13.62 ± 1.15%) as well as attenuated pathological damage after I/R injury, along with reduced levels of proinflammatory cytokines and decreased infiltration of neutrophils.</p>Conclusions<p>Our study revealed that GSDMD deficiency significantly alleviated the inflammatory response by regulating pyroptosis, reduced the infarct size and preserved cardiac function after MI/RI, thus providing a potential strategy for the treatment of myocardial reperfusion injury.…”

Image1_2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside ameliorates bleomycin-induced pulmonary fibrosis via regulating pro-fibrotic signaling pathways.jpg by Tsung-Teng Huang (167578)

“…The main purpose of this study was to investigate the protective effect of THSG against bleomycin (BLM)-induced lung fibrosis in a murine model, and explore the underlying mechanisms of THSG in transforming growth factor-beta 1 (TGF-β1)-induced fibrogenesis using MRC-5 human lung fibroblast cells. …”

DataSheet1_Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice.docx by Lu Xia (1509745)

“…</p><p>Conclusion: GSDMD-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures. Our study provides a new potential therapeutic target for seizure control.…”

Effects of BmCPV Infection on Silkworm <i>Bombyx mori</i> Intestinal Bacteria by Zhenli Sun (844483)

“…<div><p>The gut microbiota has a crucial role in the growth, development and environmental adaptation in the host insect. …”

COMPARISON OF IMPLANT DENSITY IN THE MANAGEMENT OF LENKE 1B AND 1C ADOLESCENT IDIOPATHIC SCOLIOSIS by Bekir Eray Kilinc (6303152)

“…The HD group had higher blood loss (p =.02), number of implants (p <.001), levels fused (p =.002), and surgical time (p <.001). The HD group had a higher prevalence of hypokyphosis from before operation to follow-up (p <.001). …”

DataSheet_1_Alterations of the gut microbiota in patients with immunoglobulin light chain amyloidosis.pdf by Jipeng Yan (8473710)

“…Notably, 5 optimal ASV-based microbial markers were identified as the diagnostic model of AL amyloidosis and the AUC value of the train set and the test set was 0.8549 (95% CI 0.7310-0.9789) and 0.8025 (95% CI 0.5771-1), respectively. With a median follow-up of 19.0 months, further subgroup analysis also demonstrated some key gut microbial markers were related to disease severity, treatment response, and even prognosis of patients with AL amyloidosis.…”

DataSheet_3_Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction... by Siqi Xu (429196)

“…We confirmed this mechanistic effect in a CLP-induced sepsis model of intestinal SIRT3 conditional-knockout mice, and found that melatonin preserved mitochondrial function and induced autophagy of small-intestine epithelial cells; these effects were dependent on SIRT3 activation. …”

Data_Sheet_1_Ramadan Fasting Leads to Shifts in Human Gut Microbiota Structured by Dietary Composition.pdf by Ikram Ali (10158563)

“…Principal Coordinate Analyses (PCoA) comparison of samples collected from both groups before and after fasting showed partial separation of microbiota related to fasting in the Pakistani group, but not in the Chinese group. …”

Impact of osteoarthritis disease severity on treatment patterns and healthcare resource use: analysis of real-world data by PG Conaghan (12566838)

“…Those with more severe disease place a greater demand on healthcare resources, with HCP consultations, tests, and hospital visits increasing with severity.…”

Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells by Yu-Wei Chang (34349)

“…To further understand the role of epigenetic mechanism in enhanced chemotherapeutic efficacy by estrogen, cells were pre-treated with epigenetic drugs, 5-aza-2-deoxycytidine and Trichostatin A prior to doxorubicin and cisplatin treatments. …”

Data_Sheet_1_Germination, physio-anatomical behavior, and productivity of wheat plants irrigated with magnetically treated seawater.pdf by Dalia Abdel-Fattah H. Selim (13261698)

Data_Sheet_1_Physiological, Proteomic Analysis, and Calcium-Related Gene Expression Reveal Taxus wallichiana var. mairei Adaptability to Acid Rain Stress Under Various Calcium Leve... by Wen-Jun Hu (447700)

“…Studies have shown that AR can leach calcium ions from plants and soil. Calcium (Ca) is also a crucial regulator of the plant stress response, whereas there are few reports on how Ca regulates the response of AR-resistant woody plants to AR stress. …”

Table_1_Longitudinal Changes in Diffusion Tensor Imaging Following Mild Traumatic Brain Injury and Correlation With Outcome.docx by Bo Yin (681235)

“…Neuroimaging was obtained within 7 days post-injury for acute scans and repeated at 1 and 3 months post-injury. Using a region-of-interest-based approach, tract-based spatial statistics was used to conduct voxel-wise analysis on diffusion changes in mTBI and was compared to those of healthy matched controls, scanned during the same time period and rescanned with an interval similar to that of patients. …”

Ketamine Causes Mitochondrial Dysfunction in Human Induced Pluripotent Stem Cell-Derived Neurons by Hiroyuki Ito (339050)

“…</p><p>Results</p><p>Twenty-four-hour exposure of iPSC-derived neurons to 500 μM ketamine resulted in a 40% increase in caspase 3/7 activity (<i>P</i> < 0.01), 14% increase in ROS production (<i>P</i> < 0.01), and 81% reduction in mitochondrial membrane potential (<i>P</i> < 0.01), compared with untreated cells. …”

Halostibines SbMeX₂ and SbMe₂X: Lewis Acids or Lewis Bases? by Sophie L. Benjamin (1321884)

“…Intermolecular interactions are a major feature within these systems, ranging from weak, MCO···Sb interactions in [M­(CO)₅(SbMe₂Br)] and [M­(CO)₅(SbMeBr₂)] to remarkably strong O···Sb hypervalent bonds in [Mn­(CO)₅(SbMe₂Br)]­[CF₃SO₃] and [Mn­(CO)₃(SbMe₂Br)₃]­[CF₃SO₃], the latter involving the triflate anions. …”

Image_3_DNA Methyltransferases Contribute to Cold Tolerance in Ticks Dermacentor silvarum and Haemaphysalis longicornis (Acari: Ixodidae).TIF by Desmond Onyeka Agwunobi (11333943)

“…<p>DNA methylation, mediated by DNA methyltransferases (Dnmts), is a typical epigenetic process that plays an important role in affecting organism acclimatization and adaptation to environmental changes. …”

DataSheet_1_Cynaroside ameliorates methotrexate-induced enteritis in rats through inhibiting NLRP3 inflammasome activation.docx by Wuying Lang (11259590)

“…</p>Methods<p>To assess the protective potential of cynaroside against intestinal inflammation, Sprague-Dawley rats were subjected to a regimen of 7 mg/kg MTX for 3 days, followed by treatment with cynaroside at varying doses (10, 20, or 40 mg/kg). …”

Image_11_Response of bacterial communities (Marivita, Marinobacter, and Oceanicaulis) in the phycosphere to the growth of Phaeodactylum tricornutum in different inorganic nitrogen... by Xiaoxue Wei (14672540)

“…Our results explain when and how the phycosphere bacterial communities responded to algal biomass variations. The study provides a foundation for the quantitative relationship among nutrients, microalgae, and bacteria in this system.…”

Table2_Treadmill training does not enhance skeletal muscle recovery following disuse atrophy in older male mice.docx by Elena M. Yee (14852698)

“…<p>Introduction: A hallmark of aging is poor muscle recovery following disuse atrophy. …”

Image_2_Transcriptional memory of gene expression across generations participates in transgenerational plasticity of field pennycress in response to cadmium stress.JPEG by Gengyun Li (9977678)

“…Among these traits, only SOD activity showed a significant effect of TGP; the offspring of Cd-treated individuals maintained high SOD activity in the absence of Cd stress. …”