IL-12p40 Deficiency Leads to Uncontrolled <em>Trypanosoma cruzi</em> Dissemination in the Spinal Cord Resulting in Neuronal Death and Motor Dysfunction by André Luis Bombeiro (121574)

“…Forelimb paralysis in infected IL-12p40KO mice was associated with 60% (p<0.05) decrease in spinal cord neuronal density, glutamate accumulation (153%, p<0.05) and strong demyelization in lesion areas, mostly in those showing heavy protein nitrosylation, all denoting a neurotoxic degenerative profile. …”

Data_Sheet_3_Differential effects on TDP-43, piezo-2, tight-junction proteins in various brain regions following repetitive low-intensity blast overpressure.CSV by Lanier Heyburn (7055039)

“…</p>Methods<p>In this study, using a rodent model of relBOP and western blotting for protein expression we showed the differential expression of various neuropathological proteins like TDP-43, tight junction proteins (claudin-5, occludin, and glial fibrillary acidic protein (GFAP)) and a mechanosensitive protein (piezo-2) in different regions of the brain at different intensities and frequency of blast.…”

Data Sheet 1_Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19.pdf by Aurelie Guironnet-Paquet (15407171)

“…</p>Methods<p>In this study, we set up a prospective, randomised clinical trial (ClinicalTrials.gov ID: NCT04751643) and performed therapeutic plasma exchange (TPE) in severe COVID-19 patients in order to decrease excess cytokines and auto-antibodies and to assess whether adding TPE to the standard treatment (ST, including corticosteroids plus high-flow rate oxygen) could help restore immune parameters and limit the progression of acute respiratory distress syndrome (ARDS).…”

Table_2_Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8+ T and NK Cells in Heart Transplant Patients.DOCX by Beatriz Díaz-Molina (5791361)

“…Our results imply that only early EVL conversion induces key changes in the post-transplant immune response, preserving an efficient anti-viral response, but simultaneously showing a limited ability to counteract the cytotoxic response to the allograft.…”

Table_1_Sex hormones influence the intestinal microbiota composition in mice.DOCX by Yi Wu (197719)

“…The abundance of Parasutterella is positively and negatively correlated with estradiol and testosterone (T), respectively, which may be related to the differences in the metabolism of bile acid and glucose. A decrease in the abundance of Turicibacter is closely related to autism. …”

Progress toward implementing the Swiss Hepatitis Strategy: Is HCV elimination possible by 2030? by Beat Müllhaupt (416436)

“…<div><p>Catalyzed by the concerns over the growing public health and economic burden of Hepatitis C virus (HCV) in Switzerland, a diverse group of experts and patient representatives came together in 2014 to develop the Swiss Hepatitis Strategy, setting targets for the elimination of viral hepatitis in Switzerland by 2030. …”

Phenotype data of the meta-analysis cohorts. by Anu Pasanen (6836672)

“…<div><p>Background</p><p>Preterm birth (<37 weeks of gestation) is a major cause of neonatal death and morbidity. …”

Table_2_Developmental, Morphological and Physiological Traits in Plants Exposed for Five Generations to Chronic Low-Level Ionising Radiation.XLSX by Nicol M. Caplin (8710839)

“…This is explained by the redundancy and/or degeneracy between biological levels of organization in plants that produces a relatively loose association between genotype and phenotype. …”

Light-driven Locomotion of Underwater Bubbles on Ultrarobust Paraffin-impregnated Laser-ablated Fe₃O₄‑doped Slippery Surfaces by Zhouchen Huang (6672761)

“…The underlying principle is that when the NIR was applied, UGB would be actuated to slide along the NIR trace because the irradiated domain melts for a slippery surface within 1.0 s. Once the NIR is removed, the liquefied paraffin would be reconfigured to solid phase for pinning a moving UGB within 0.5 s. …”

Image 5_Blastocystis infection in Tibetan antelopes (Pantholops hodgsonii) alters gut microbiota composition and function.tif by Jian Liu (33711)

“…Functional profiling showed a decrease in metabolic diversity, with 18 CAZy families detected in the healthy group but only 2 in the infected group. …”

Light-driven Locomotion of Underwater Bubbles on Ultrarobust Paraffin-impregnated Laser-ablated Fe₃O₄‑doped Slippery Surfaces by Zhouchen Huang (6672761)

“…The underlying principle is that when the NIR was applied, UGB would be actuated to slide along the NIR trace because the irradiated domain melts for a slippery surface within 1.0 s. Once the NIR is removed, the liquefied paraffin would be reconfigured to solid phase for pinning a moving UGB within 0.5 s. …”

datasheet1_In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis.docx by Dahara Keyse Carvalho Silva (9774635)

“…Also, in vivo treatment of BALB/c mice infected with L. amazonensis resulted in a decrease of lesion size, parasitic load and caused histopathological alterations, when compared to vehicle-treated control. …”

Distinct Peripheral Blood RNA Responses to <em>Salmonella</em> in Pigs Differing in <em>Salmonella</em> Shedding Levels: Intersection of IFNG, TLR and miRNA Pathways by Ting-Hua Huang (192546)

“…We confirmed the activation of two regulatory factors, SPI1 and CEBPB, and demonstrated that expression of miR-155 was decreased specifically in the PS animals. These data provide insight into specific pathways associated with extremes in <em>Salmonella</em> fecal shedding that can be targeted for further exploration on why some animals develop a carrier state. …”

Image_2_Endocannabinoids Produced by White Adipose Tissue Modulate Lipolysis in Lean but Not in Obese Rodent and Human.tiff by Chloé Buch (9093966)

“…In the present study, we used different strategies to acutely increase ECS activity in WAT and tested the consequences on glycerol production as a marker of lipolysis. Treating lean mice or rat WAT explants with JLZ195, which inhibits ECs degrading enzymes, induced an increase in 2-AG tissue contents that was associated with a CB1R-dependent decrease in lipolysis. …”

Image_2_Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transc... by Weijie Yang (3625022)

“…Mice were treated with a single dose of CTX (100 mg/kg) at post-natal day 21 and sacrificed 47 days later when primordial follicles surviving chemotherapy developed to the antral stage. …”

Ion Transport Analysis of Anion-Exchange Membranes in Various Hydration States: Combining Experiments with Molecular Dynamics Simulation by Yuri Nara (22402134)

“…To overcome these issues, it is crucial to understand how the polymer morphology changes with hydration states and why low humidity conditions lead to a decrease in anion conductivity. In the present study, all-atom molecular dynamics (MD) simulations have been carried out to elucidate the hydration structure of trimethylammonium-substituted polyfluorene (TMA-PF), previously reported by the authors [Nara et al., <i>Polym. …”

Image_1_The association between sugar-sweetened beverages and milk intake with emotional and behavioral problems in children with autism spectrum disorder.tiff by Si Tan (547511)

“…The frequency of SSBs and milk intake was assessed by a self-designed questionnaire. Emotional and behavioral problems were assessed by Strength and Difficulties Questionnaire (SDQ). …”

Table_2_Age Related Changes in Topological Properties of Brain Functional Network and Structural Connectivity.DOCX by Chandan Shah (5216960)

“…These brain regions also had both direct and indirect anatomical relationships with the 14 fiber bundles. A linear age related decreases in the Fractional anisotropy (FA) value was found in the callosum forceps minor.…”

Novel Quinazolinone MJ-29 Triggers Endoplasmic Reticulum Stress and Intrinsic Apoptosis in Murine Leukemia WEHI-3 Cells and Inhibits Leukemic Mice by Chi-Cheng Lu (163756)

“…Our results indicated that a concentration-dependent decrease of cell viability was shown in MJ-29-treated cells. …”

Data_Sheet_4_Differential effects on TDP-43, piezo-2, tight-junction proteins in various brain regions following repetitive low-intensity blast overpressure.CSV by Lanier Heyburn (7055039)

“…</p>Methods<p>In this study, using a rodent model of relBOP and western blotting for protein expression we showed the differential expression of various neuropathological proteins like TDP-43, tight junction proteins (claudin-5, occludin, and glial fibrillary acidic protein (GFAP)) and a mechanosensitive protein (piezo-2) in different regions of the brain at different intensities and frequency of blast.…”