Data_Sheet_1_Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson’s disease.docx by Fahad Mubariz (16010003)

“…Using PD patients’ induced-pluripotent stem cells (iPSCs), we examined TFEB activity and regulation of the ALP in dopaminergic neuronal cultures generated from iPSC lines harboring heterozygous GBA1 mutations and the CRISPR/Cas9-corrected isogenic controls. Our data showed a significant decrease in TFEB transcriptional activity and attenuated expression of many genes in the CLEAR network in GBA1 mutant neurons, but not in the isogenic gene-corrected cells. …”

Bad to the Bone: On <i>In Vitro</i> and <i>Ex Vivo</i> Microbial Biofilm Ability to Directly Destroy Colonized Bone Surfaces without Participation of Host Immunity or Osteoclastoge... by Adam Junka (3633286)

“…Presence of biofilm led to bone dissolution with a decrease of total volume by 20.17±2.93% upon microcomputed tomography analysis, which was statistically significant as compared to controls (p <0.05, ANOVA). …”

DataSheet_1_E2F1 mediates competition, proliferation and response to cisplatin in cohabitating resistant and sensitive ovarian cancer cells.docx by Andres Valdivia (16546941)

“…Direct co-culture led to a decrease in the IC50 to platinum in the cisplatin-sensitive cells (5.92 µM to 2.79 µM for PE01, and from 2.05 µM to 1.51 µM for OVCAR5). …”

Table 1_Global, regional and national burdens of otitis media in children and adolescents from 1990 to 2021 and its predictions to 2040.xlsx by Ru Chen (186859)

“…At the national level, countries with a high burden of OM are primarily concentrated in Sub-Saharan Africa and South Asia. …”

Table_2_Evolution of the S-Genomes in Triticum-Aegilops Alliance: Evidences From Chromosome Analysis.docx by Alevtina S. Ruban (6039062)

“…Evolution of Emarginata species was associated with an increase of C-banding and (CTT)₁₀-positive heterochromatin, amplification of Spelt-52, re-pattering of the pAesp_SAT86, and a gradual decrease in the amount of the D-genome-specific repeats pAs1, pTa-535, and pTa-s53. …”

Data Sheet 1_Cervical cancer burden and attributable risk factors across different age and regions from 1990 to 2021 and future burden prediction: results from the global burden of... by Lu-yao Cheng (20687651)

“…Background<p>Cervical cancer (CC) is a global public health problem. We aimed to evaluate the global and regional CC burden between 1990 and 2021, identify the attributable risk factors, and project its burden up to 2035.…”

DataSheet1_Shaoyao-Gancao Decoction Ameliorates the Inflammation State in Polycystic Ovary Syndrome Rats via Remodeling Gut Microbiota and Suppressing the TLR4/NF-κB Pathway.PDF by Zhuang-peng Chang (10792212)

“…In addition, SGD treatment decreased releases of pro-inflammatory cytokines, enhanced the expressions of tight junction (occludin and claudin1), and then prevented a translocation of LPS into bloodstream. …”

Source data for graphs in this study. by Dominique Dorin-Semblat (832845)

“…We also report that two specific CK2 inhibitors reduce infected erythrocytes adhesion to CSA and decrease the phosphorylation of the recombinant extracellular region of VAR2CSA using either infected erythrocytes lysates as a source of kinases or recombinant Human and <i>P</i>. …”

Image_1_Aberrant Gut Microbiome Contributes to Intestinal Oxidative Stress, Barrier Dysfunction, Inflammation and Systemic Autoimmune Responses in MRL/lpr Mice.tif by Hui Wang (30400)

“…Interestingly, each mouse strain had distinct bacterial community as revealed by β-diversity. A lower Firmicutes/Bacteroidetes ratio in 6-week-old MRL/lpr mice was observed, evidenced by decrease in Peptostreptococcaceae under Firmicutes phylum along with enrichment of Rikenellaceae under Bacteroidetes phylum. …”

Table_3_Correlations Between Structural Brain Abnormalities, Cognition and Electroclinical Characteristics in Patients With Juvenile Myoclonic Epilepsy.docx by Jun Zhang (48506)

“…Voxel-based morphometry (VBM) and surface-based morphometry (SBM) analyses were performed. They also underwent a series of neuropsychological tests to assess cognitive function. …”

The TREC/KREC Assay for the Diagnosis and Monitoring of Patients with DiGeorge Syndrome by Eva Froňková (671606)

“…Both TREC and KREC levels showed a more pronounced decrease with age in DGS patients than in controls (p<0.0001 for both in a linear model). …”

Table_3_Metabolomics analysis of splenectomy of Nile tilapia (Oreochromis niloticus) reveals the spleen involved in regulating liver lipids and amino acids metabolism.docx by Yixi Tao (11036286)

“…After splenectomy, biochemical parameters of the liver and serum showed abnormalities, including significant increases in total cholesterol (T-CHO) and serum total bile acid (TBA) levels, alongside a significant decrease in liver TBA levels, suggesting impaired metabolic function and cholesterol deposition in the liver. …”

Table_1_Environmental and Biological Determinants of Algal Lipids in Western Arctic and Subarctic Seas.DOCX by Vincent Marmillot (9912234)

“…Among specific FAs, eicosapentaenoic acid (EPA; 20:5ω3) was positively correlated with diatoms but the expected relationship between docosahexaenoic acid (DHA; 22:6ω3) and dinoflagellates was not observed. Decreasing pH had a negative effect on EPA and MUFA proportions, and DHA proportions tended to decrease with higher temperature. …”

Image_1_Modulation of low-dose ozone and LPS exposed acute mouse lung inflammation by IF1 mediated ATP hydrolysis inhibitor, BTB06584.tif by Pahul Singh (14781409)

“…Ozone and LPS exposure induced lung neutrophil and eosinophil recruitment as measured by respective peroxidase (MPO and EPX) assays, systemic leukopenia, increased levels of lung vascular neutrophil regulatory chemokines such as CXCL5, SDF-1, CXCL13 and a decrease in immune-regulatory chemokines such as BAL IL-10 and CCL27. …”

Original data. by Haifeng Chang (386047)

“…</p><p>Conclusion</p><p>The COVID-19 pandemic has impacted trauma patients admitted through the emergency department, with increases in the proportion of male and younger patients, surgical cases, and a decrease in mortality rates during the pandemic.…”

Table1_Serial RV wall stress measurements: association with right ventricular function in repaired Tetralogy of Fallot patients.docx by Savine C. S. Minderhoud (9385574)

“…</p>Results<p>Increased wall stress correlated with lower RV mass (r_rm= −0.70, p = 0.017) and lower RV mass-to-volume (r_rm= −0.80, p = 0.003) using repeated measures. Wall stress decreased significantly over time, especially in patients with a stable RVEF (p < 0.001). …”

Image_3_SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells.tiff by Toshio Kanno (13266066)

“…By employing ChIP-seq analyses, we found a substantial percentage of the IRF9 target genes were shared by sgScd2 and IFNβ-treated Th1 cells. …”

Table_4_Correlations Between Structural Brain Abnormalities, Cognition and Electroclinical Characteristics in Patients With Juvenile Myoclonic Epilepsy.docx by Jun Zhang (48506)

“…Voxel-based morphometry (VBM) and surface-based morphometry (SBM) analyses were performed. They also underwent a series of neuropsychological tests to assess cognitive function. …”

Exposure to 50 Hz electromagnetic field changes the efficiency of the scorpion alpha toxin by Milena Jankowska (5671298)

“…We observed a decrease of the toxin effect on the cercal nerve activity, but the toxic effect of LqhαIT on the connective nerve was increased. …”

Data_Sheet_3_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.PDF by Yujia Zhang (757462)

“…The cell morphology altered dramatically 72 h after transfection, becoming rounder, with a decrease in cell number. BCP exhibited the potential to dramatically increase PC-12 cell viability while protecting cell morphology. …”