Secondary Dyslipidemia In Obese Children - Is There Evidence For Pharmacological Treatment? by Graciane Radaelli (5186603)

“…Objective: Systematic review of randomized clinical trials of statin use to treat children and adolescents with dyslipidemia secondary to obesity. Methods: We performed a search in PubMed, EMBASE, Bireme, Web of Science, Cochrane Library, SciELO, and LILACS for data to evaluate the effect of statins on: improvement of surrogate markers of coronary artery disease in clinical outcomes of adulthood; increased serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipropotein B (APOB); and decreased serum levels of high-density lipoprotein cholesterol (HDL-C) from inception to February 2016. …”

Secondary Dyslipidemia In Obese Children - Is There Evidence For Pharmacological Treatment? by Graciane Radaelli (5186603)

“…Objective: Systematic review of randomized clinical trials of statin use to treat children and adolescents with dyslipidemia secondary to obesity. Methods: We performed a search in PubMed, EMBASE, Bireme, Web of Science, Cochrane Library, SciELO, and LILACS for data to evaluate the effect of statins on: improvement of surrogate markers of coronary artery disease in clinical outcomes of adulthood; increased serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipropotein B (APOB); and decreased serum levels of high-density lipoprotein cholesterol (HDL-C) from inception to February 2016. …”

Clazosentan: First Approval by Arnold Lee (8502113)

“…ET_A receptor inhibition by clazosentan decreases ET-related cerebral vasospasm, which may occur after an aneurysmal subarachnoid haemorrhage. …”

Annexin A1 and A2: Roles in Retrograde Trafficking of Shiga Toxin by Lionel Tcatchoff (152994)

“…Knockdown of annexin A1 increases Golgi transport of Stx, whereas knockdown of annexin A2 slightly decreases the same transport step. …”

Supplementary Material for: Association of <i>AHSG</i> Gene Polymorphisms and Aortic Stiffness in Peritoneal Dialysis Patients by Jung J.Y. (4122502)

“…Decreased serum concentration of fetuin-A is independently related to all-cause and cardiovascular mortality in dialysis patients. …”

Lack of HP1a or POF shifts the enrichment pattern of RNA pol II on chromosome 4. by Nicole C. Riddle (134424)

“…Scatter plot showing enrichment of RNA pol II at the promoter region (+/−500 bp of TSS, top panel) and gene body (bottom panel). In both HP1a and POF mutants, the RNA pol II enrichment decreases significantly only in the gene body. …”

The effect of eEF1A mutations on TBSV repRNA accumulation in yeast. by Zhenghe Li (238151)

“…(C) Critical eEF1A residues for tombusvirus replication. Three novel mutants of eEF1A were identified, which exhibited increased tombusvirus replication (V301D, L374V/N377K, and F413L; yellow balls) while the new A76V and the previously identified T22S exhibited decreased tombusvirus replication (green balls). …”

Table 1_Epidemiology and genetic characteristics of coxsackievirus A16 associated with hand-foot-mouth disease in Hangzhou city, Zhejiang province from 2021 to 2024.docx by Qihao Xu (5513795)

“…The detected number of CV-A16 began to rise in March, peaked in May–August, and then decreased in September. …”

Retinol and mineral status in grazing foals during the dry season by Maria Lindomárcia Leonardo da Costa (12802135)

“…Beta-carotene in grass showed a downward trend over time from 38.53 to 0.09 mg/kg of dry matter. …”

Data Sheet 1_Semaglutide attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis of cardiomyocytes via activation of PKC-S100A9 axis.pdf by Yan Liu (25061)

“…In vitro, experiments showed that semaglutide decreased the expression of S100A9 by activating the Protein Kinase C(PKC) pathway, thus inhibiting ferroptosis in cardiomyocytes.…”

Data Sheet 2_Semaglutide attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis of cardiomyocytes via activation of PKC-S100A9 axis.docx by Yan Liu (25061)

“…In vitro, experiments showed that semaglutide decreased the expression of S100A9 by activating the Protein Kinase C(PKC) pathway, thus inhibiting ferroptosis in cardiomyocytes.…”

Table 1_Semaglutide attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis of cardiomyocytes via activation of PKC-S100A9 axis.docx by Yan Liu (25061)

“…In vitro, experiments showed that semaglutide decreased the expression of S100A9 by activating the Protein Kinase C(PKC) pathway, thus inhibiting ferroptosis in cardiomyocytes.…”

Image 1_Epidemiology and genetic characteristics of coxsackievirus A16 associated with hand-foot-mouth disease in Hangzhou city, Zhejiang province from 2021 to 2024.jpeg by Qihao Xu (5513795)

“…The detected number of CV-A16 began to rise in March, peaked in May–August, and then decreased in September. …”

Supplementary Material for: The Designer Antimicrobial Peptide A-hBD-2 Facilitates Skin Wound Healing by Stimulating Keratinocyte Migration and Proliferation by Mi B. (5999321)

“…<b><i>Conclusion:</i></b> Our data suggest that A-hBD-2 may be a promising candidate therapy for wound healing.…”

CsrA modulates the expression of a thiamine pyrophosphate (TPP) riboswitch element. by Tobias Sahr (3756775)

“…Each value represents the mean +/- SD of three independent experiments. BlaM activity is significantly decreased in the mutant at the different conditions indicating a positive effect of CsrA on the <i>thi</i>-operon expression in <i>L</i>. …”

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach by P., Sneha

“…Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. …”
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Comparative skull analysis suggests species-specific captivity-related malformation in lions (Panthera leo) by Saragusty, Joseph

“…Lion (Panthera leo) populations have dramatically decreased worldwide with a surviving population estimated at 32,000 across the African savannah. …”
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A Unique Modification of the Eukaryotic Initiation Factor 5A Shows the Presence of the Complete Hypusine Pathway in <em>Leishmania donovani</em> by Bhavna Chawla (176976)

“…<div><p>Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of an unusual amino acid hypusine (<em>N</em>^€-(4-amino-2-hydroxybutyl) lysine), which is present on only one cellular protein, eukaryotic initiation factor 5A (eIF5A). We present here the molecular and structural basis of the function of DOHH from the protozoan parasite, <em>Leishmania donovani,</em> which causes visceral leishmaniasis. …”

Efmoroctocog Alfa: A Review in Haemophilia A by James E. Frampton (4995257)

“…</p> <p><b> </b></p> <p><b>Authorship and Conflict of interest</b> James E. Frampton is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. …”

<i>S</i>. <i>aureus</i> binding activity to Seraph^® 100 during a prolonged treatment period. by Malin-Theres Seffer (14808772)