Effects of dapagliflozin on HK2 cell survival and apoptosis. by Yoon-Kyung Chang (3155658)

“…(B) Representative western blot (B-a). Dapagliflozin significantly decreased the Bax expression and Bax/Bcl2 ratio in hypoxic HK2 cells (B-b and d). …”

The assessment of grip strength in preschool-aged children with and without unilateral cerebral palsy by Griet Dequeker (18059414)

“…</p> <p>We assessed grip strength in 20 pre-school-aged children with predominantly spastic uCP (mean age 4y0 ± 1y2m) and 20 age-matched children without uCP (mean age 3y11m ± 1y3m) using the Martin Vigorimeter and MyoGrip to investigate test-retest reliability (intraclass correlation coefficients; ICC), known-group validity (comparative statistics) and convergent validity (correlation analyses) in a cross-sectional design.…”

Focal Ischemic Injury with Complex Middle Cerebral Artery in Stroke-Prone Spontaneously Hypertensive Rats with Loss-Of-Function in NADPH Oxidases by Hiroshi Yao (562206)

“…<div><p>By means of introgressing a loss-of-function mutation in the <i>p22phox</i> gene from the Matsumoto Eosinophilia Shinshu (MES) rat to stroke-prone spontaneously hypertensive rats (SHRSP), we constructed the SHRSP-based congenic strain lacking the P22PHOX expression (i.e., lacking NADPH oxidases [NOX] activities) (SHRSP.MES-<i>Cyba</i>^<i>mes</i>/Izm; hereafter referred to as SP.MES). …”

Region D is transactivated by ETS and GATA factors. by Alexandra Le Bras (243728)

“…Bars represent normalized activity as fold over the Ctrl mean value of either Luc reporter set to 1. Left; scaled schematic representation of region D. …”

<i>In vitro</i> blocking effect of PD-1-PD-L1 interactions on the effector T cell functions and survival among PTB patients. by Amar Singh (134922)

“…Lymphocytes were gated based on their scatter (FSC/SSC) profile and further gated on CD3⁺ T cells. (<b>A</b>) Representative FACS plots shows production of IFN-γ by CD3⁺ T cells which markedly increases upon blocking PD-1-PD-L1 interaction (<b>B</b>) Each histogram depicts the effect of PD-1, PD-L1 blocking on the percentage of IFN-γ⁺ CD3⁺ T cells (mean ± S.E.M. for n = 8). …”

The enumeration of neuronal cell in myenteric ganglia. by Yong Hwan Kwon (3612245)

“…(B) The percent of nNOS positive neuronal cells of total neuronal cells in ganglion of 74-wk-old and 2-yr-old rats was significantly lower than that of 6- and 31-wk-old rats (<i>P</i> = 0.002, 6-wk- <i>vs</i>. 74-wk-old rats; <i>P</i> = 0.002, 6-wk- <i>vs</i>. 2-yr-old rats; <i>P</i> = 0.041, 31-wk- <i>vs</i>. 74-wk-old rats, and <i>P</i> = 0.019, 31-wk- vs 2-yr-old rats). (C) Mean of proportion of nNOS-immunoreactive area in ganglion was also decreased as age increased (<i>P</i> = 0.020, 6-wk- <i>vs</i>. 31-wk-old rats; <i>P</i> = 0.001, 6-wk- <i>vs</i>. 74-wk-old rats; <i>P</i> < 0.001, 6-wk- <i>vs</i>. 2-yr-old rats; <i>P</i> < 0.001, 31-wk- <i>vs</i>. 2-yr-old rats, and <i>P</i> < 0.001, 74-wk- vs 2-yr-old rats). …”

Localization of CCL2 and CCR2 after spinal cord injury (SCI). by Kazumichi Yagura (4537504)

“…<p><b>(A)</b> CCL2⁺ cells (<i>green</i>) were observed around the site of SCI on day 1 and were merged with the neuronal marker NeuN (<i>red</i>) (arrows). …”

Psychophysical performance of Exposed (square data points) and Unexposed (round data points) groups. by Thomas J. Brozoski (421479)

“…<b>A</b>. Pre-D-AP5 treatment there was no difference between the two exposed groups (error bars in all panels indicate the standard error of the mean) and both were significantly different than the Unexposed group (statistics summarized in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0077674#pone-0077674-t001" target="_blank">Table 1</a>, section 1). …”

Classification of stages of CKD in rats. by Barbara Mara Klinkhammer (542578)

“…<p>All remnant kidney rats (“RK”) were sacrificed after a renal disease duration >17 weeks (mean life expectancy of a healthy lab rat ≈75 weeks). …”

Arthritis severity is inhibited in TSLPR deficient mice and upon blockade of the IL-7R. by Maarten R. Hillen (760783)

“…IL-7R blockade, TSLPR deficiency or a combination of both significantly decreased arthritis severity compared to PBS WT mice (A). …”

The probability of the agent choosing <i>left</i> for each probability pair in the switching reward probability task. by Kim T. Blackwell (10915047)

“…Agents that calculate mean reward using a moving average window = 1 trial exhibit more switching behavior, especially for non-rewarded trials.…”

Effects of combining amputation and suspension on fly walking. by Abhishek Chadha (655681)

“…Amputated and suspended flies display a robust increase in backtracking that gradually decreases. …”

Plasma pharmacokinetics and brain uptake of 2B3-101 and pegylated liposomal doxorubicin in healthy mice. by Pieter J. Gaillard (506968)

“…<p>(A) Plasma concentration after 1 IV dose (5 mg/kg in 3 mice per group per time point) decreases with time for both liposomal formulations. …”

TAK1^ΔM mice develop splenomegaly and have shortened lifespans. by Betty Lamothe (57187)

“…<p>(<b>A–B</b>) Decreased body weights of aged TAK1^ΔM mice. …”

Probing the auditory nerve using round-window response in control and ouabain-poisoned cochleae. by Charlène Batrel (3639406)

“…<p><b>(A, B)</b> Iso-level neural index in control (<b>A</b>, <i>n</i> = 10 gerbils) and ouabain-poisoned cochleae (<b>B</b>, <i>n</i> = 9 gerbils). …”

Probucol ameliorates apoptosis in hyperoxic lung injury. by Tomonobu Kawaguchi (3910612)

“…<p>(A-D) The effect of probucol on TUNEL staining. …”

Tuning of Msn2 expression in rapidly growing cells. by Michal Chapal (7961111)

“…(F–G) Noisy Msn2 expression decreases stress protection and growth rate: we generated six strains with Msn2-YFP expressed under different promoters, which control genes with noisier expression than Msn2 but have a similar mean abundance (mean abundance in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000289#pbio.3000289.s005" target="_blank">S5 Fig</a>), and deletion of <i>MSN4</i>. …”

TNBS colitis reduces body weight, shortens colon length, damages epithelial barrier integrity and increases colonic IL-1β. by Ben R. Hofma (5439746)

“…<p>A) Body weight was significantly reduced 24 and 48 hours following TNBS treatment relative to healthy controls (▲ Healthy, ● TNBS, N = 10). …”

Learning functional subgraph architecture of cognitive control processes. by Ankit N. Khambhati (838251)

“…(<i>F</i>) We rank functional subgraphs in decreasing order (A-L) of the difference between positive and negative expression weight, averaged over task blocks and subjects. …”

Inhibition of PI3K/Akt signal pathway increased chemotherapeutic sensitivity and promoted apoptosis of shRNA transfected cisplatin resitant cells. by Yan Wang (15435)

“…<p>A: A549DDP and H460DDP cells transfected with shRNA were treated with LY294002 (10 and 40 µM). …”