Spatiotemporal Stability of Neonatal Rat Cardiomyocyte Monolayers Spontaneous Activity Is Dependent on the Culture Substrate by Jonathan Boudreau-Béland (748629)

“…We compared PDMS to the gold standard normally used in culture: a glass substrate. Although mean frequency of spontaneous activity remained unaltered, incidence of reentrant activity was significantly higher in samples cultured on glass compared to PDMS substrates. …”

SNAP23 is important for endothelial exocytosis. by Qiuyu Zhu (422828)

“…(C) SNAP23 knockdown decreases endothelial exocytosis. HDMVEC and HUVEC were treated with siControl or siSNAP23, stimulated with serum-free medium only (resting), or 10 μM histamine, or 1 U/ml thrombin, or 10 μM Ca²⁺ ionophore A23187 for 30 min; and then VWF released into the media was measured by an ELISA (n = 4–7; * P < 0.05 vs. siControl; NS, non-significant vs. siControl). …”

Loss of proliferative potential and anti-tumor cytotoxicity in CTLs is reversible. by Mary Zimmerman (357472)

“…Proliferation was measured by analyzing ³H-thymidine incorporation 2 days after the second tumor cell re-stimulation. <i>Column</i>, mean; <i>bar</i>, SD. <b>B</b>. The decreased anti-tumor cytotoxicity of CD3 mAb-stimulated CTLs can be enhanced by antigen re-stimulation. …”

Vascular thickness histograms. by Susann Minkwitz (2214142)

“…Data are represented as mean with standard deviations in one direction for better visualization. …”

Identification by proteomic analysis of lipogenic enzymes suppressed in the white adipose tissue in response to the high-fat diet challenge. by Lei Jiang (73366)

“…<p>(A) Protein extracts of the epididymal fat pad from mice fed LFD vs. …”

Type 1 neurons appear to be mostly depolarized and differentially synchronized by PDF. by Hongying Wei (636975)

“…Correlation coefficients of calcium levels at the timing of Ca²⁺ peaks between any two isolated, dispersed pacemakers before (blue) and after PDF (500 nM) application (red) indicate that PDF decreases the phase difference between cell pairs with “in phase” activity (direct correlation), as well as pairs with “out of phase activity” (inverse correlation) (paired t-test, with standard error of the mean, SPSS 13.0). …”

Quantitative analysis of the expression of genes involved in bone formation and bone resorption. by Hye-Rim Lee (504509)

“…Compared to the control, the expression level of type I collagen and osteocalcin of MC3T3-E1 cells was increased and those of Runx2, Rankl, MMP3 and MMP13 gene expression were decreased, each of which occurred in a time-dependent manner. …”

Co-culture can overcome low viral gene expression. by Peng Zhong (106399)

“…<p>(<b>A</b>) A barrier was placed into the cell-free path of HIV by lowering viral gene expression. …”

Anatomical confirmation of drug injection sites. by Diana Amorim (662998)

“…Limb withdrawal threshold four weeks after the induction of monoarthritis in the right knee, arthritic animals display a decreased limb withdrawal threshold in the right hind limb in the pressure application measurement test when compared to the left hind limb (<b>K</b>). …”

sCD25 inhibits IL-2R signalling by sequestering secreted IL-2. by Shane E. Russell (303031)

“…<p>(<b>A–D</b>) Purified naive CD4+ T cells activated for 24 hrs under Th17 inducing conditions in the presence or absence of sCD25 and examined for levels of (<b>A</b>) p-Stat5 pY694, (<b>B</b>) intracellular IL-2 expression (<b>C</b>) surface binding of sCD25-His and (<b>D</b>) surface expression of endogenous CD25 by FACS analysis. …”

Effects of resveratrol (RES) on <i>I</i>_Na.L under control condition (Con) in rabbit ventricular myocytes. by Chunping Qian (294424)

“…<p><i>A.</i> 10, 20, 40 and 80 µM resveratrol decreased the amplitude of <i>I</i>_Na.L in a concentration dependent manner. …”

QM56 reduces the degree of renal disfunction and damage in acute kidney injury. by Álvaro C. Ucero (108367)

“…QM56 decreased the magnitude of renal failure as assessed by: plasma urea and creatinine (*p<0.01 vs Control, **p<0.05 vs FA) (<b>A</b>), tubular cell apoptosis as assessed by TUNEL® (*p<0.01 vs Control, **p<0.05 vs FA) and immunohistochemistry of caspase-3 (*p<0.01 vs Control, **p<0.02 vs FA) (<b>B,C</b>) and Kim-1 and Ngal mRNA hindered synthesis (*p<0.01 vs Control, ^#p<0.01 vs FA, **p<0.05 vs FA) (<b>D</b>). …”

Differentiation block in CEABAC mouse colonic epithelium at 3 weeks of age. by Carlos H. F. Chan (37435)

“…<p>A) Mucin staining of colonic crypts of WT, CEABAC2, CEABAC10, and CEABAC20 mice shows a progressively decreasing number of visible purplish-colored differentiated goblet cells (indicated by an arrow in the WT colonic crypt) correlated with increasing CEABAC transgene copy number. …”

Histological analysis of the effect of ocular HPC on retinal ischemic damage. by Ezequiel M. Salido (405989)

“…<p>Effect of ocular HPC on total retinal and retinal layer thicknesses (in µm) in non-ischemic or ischemic eyes. Ischemia decreased total retinal, ONL, INL and IPL thickness, and GCL Brn3a(+) cell number. …”

Inhibition of CBP-interacting factors attenuates lifespan extension by bDR. by Minhua Zhang (257271)

“…However, <i>cbp-1</i> RNAi blocks induction of (F), <i>sod-3</i>, (G) <i>sip-1</i>, <i>and</i> (I) W03F9.4/CPT-1 and inhibition of (H) Y71H10A.1 by bDR. Data are presented as mean ± SEM (<i>n</i> = 4–6/group, *<i>p</i><0.05).…”

Meth alters NK cell subsets. by Robert Harms (295592)

“…</b> Meth treatment results in a decreased proportion of KLRG1⁻, CD27⁺ NK cells with an increase in proportion of KLRG1⁺, CD27⁻ NKs. …”

Results of the motor tests. by Kumiko Yonezaki (711887)

“…<p>(A) In the rotarod test, no significant differences were observed among the three groups. …”

Scatterplots of the differences between the negative MD and PSD values with respect to the visual field index in each group. by Dong Won Heo (3804817)

“…The mean “−MD−PSD” was −0.32 dB, and the 95% confidence interval ranged from −2.48 dB to 1.84 dB. …”

Flow cytometry-based assay for rECD-binding. by Anna Gaertner (127899)

“…The ratio_rECD-bound was significantly (p<0.01) decreased from 1.21±0.03 for samples incubated in 5 mM CaCl₂ (1) to 1.05±0.03 for samples incubated with 2 mM EGTA (2) showing that rECD-wt has a Ca²⁺-dependent binding to HT1080 cells. …”

Effect of Glucose Concentration on Life Span and Sir2 Activity in Respiratory-Deficient Mutants by Matt Kaeberlein (12437)

“…<div><p>(A) Mean replicative life span is significantly increased in PSY316 AUT <i>cyt1</i>Δ and rho⁰ cells as the glucose concentration is decreased to either 0.5% or 0.05%, relative to life span on 2% glucose. …”