Showing 14,081 - 14,100 results of 48,899 for search '(( a ((mean decrease) OR (linear decrease)) ) OR ( a ((greatest decrease) OR (largest decrease)) ))', query time: 0.94s Refine Results
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    Phase 1 study to evaluate the effects of rifampin or itraconazole on the pharmacokinetics of limertinib (ASK120067), a novel mutant-selective inhibitor of the epidermal growth fact... by Bei Cao (141848)

    Published 2023
    “…</p> <p>Coadministration of rifampin decreased exposure (area under the plasma concentration-time curve from time 0 to infinity, AUC<sub>0-inf</sub>) of limertinib and its active metabolite CCB4580030 by 87.86% (geometric least-squares mean [GLSM] ratio, 12.14%; 90% confidence interval [CI], 9.89–14.92) and 66.82% (GLSM ratio, 33.18%; 90% CI, 27.72–39.72), respectively. …”
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