Effect of dietary squalene supplementation on plasma parameters in male wild-type mice. by Clara Gabás-Rivera (613994)

Effect of dietary squalene supplementation on plasma parameters in male <i>Apoa1</i>-deficient mice. by Clara Gabás-Rivera (613994)

Functional validation of a miRNA-34a-TREM2–3’UTR interaction. by Surjyadipta Bhattacharjee (3181674)

“…<p><b>(A)</b> ribonucleotide sequence of the 299 nt TREM2-mRNA-3’-UTR is shown in the 5’-3’ direction; the 22 nt miRNA-34a-TREM2 3’UTR complementarity-interaction region is indicated by a black underline and the 8 nt TREM2-mRNA-3’-UTR seed sequence <b>5’-ACACUGCU-3’</b> is overlaid in yellow; a single arrowhead indicates the 5’ end of a poly A+ tail in the TREM2 mRNA (22 ‘A’ nt shown; the length of this poly A+ tail is variable); TREM2 mRNA sequence derived from NM_018965; TREM2 transcript is the major X1 variant (see also <a href="http://switchdb.switchgeargenomics.com/productinfo/id_801321/" target="_blank">http://switchdb.switchgeargenomics.com/productinfo/id_801321/</a>) (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a></b>); <b>(B)</b> TREM2-mRNA-3’UTR expression vector luciferase reporter assay (pLightSwitch-3’UTR; Cat#S801178; Switchgear Genomics, Palo Alto CA); in this vector, the entire 299 nucleotide TREM2 3’UTR was ligated into the unique Nhe1-Xho1 site; <b>(C)</b> control C8B4 murine microglial cells, 1 week in culture; phase contrast bright field microscopy 20x; C8B4 cells transfected with the TREM2-mRNA-3’UTR expression vector luciferase reporter were treated exogenously with miRNA-34a, a scrambled control miRNA-34a (miRNA-sc) or control miRNA-183; see references and text for further details [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref018" target="_blank">18</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref019" target="_blank">19</a>]; <b>(D)</b> compared to control, C8B4 cells transfected with a scrambled (<b>sc</b>) control pLightSwitch-3’UTR vector, the TREM2-mRNA-3‘UTR vector exhibited decreased luciferase signal to a mean of 0.16-fold of controls in the presence of miRNA-34a; this same vector exhibited no change in the presence of the control miRNA-34a-sc or miRNA-183; for each experiment (using different batches of MG cells) a control luciferase signal was generated and included separate appropriate controls with each analysis; in addition a control vector β-actin-3’UTR showed no significant effects on the relative luciferase signal yield after treatment with either miRNA-183 or miRNA-34a (data not shown); dashed horizontal line set to 1.0 for ease of comparison; N = 5; *<i>p</i><0.001 (ANOVA). …”

S1 Data - by Shuxian Li (176926)

“…We find that firms with higher Google search volume experience a 10% decrease in stock price informativeness after the Google withdrawal. …”

Descriptive statistics. by Shuxian Li (176926)

“…We find that firms with higher Google search volume experience a 10% decrease in stock price informativeness after the Google withdrawal. …”

Test for validity of the DID model specification. by Shuxian Li (176926)

“…We find that firms with higher Google search volume experience a 10% decrease in stock price informativeness after the Google withdrawal. …”

<i>P</i>. <i>aeruginosa</i> biofilm formation is decreased by reducing potassium efflux from airway epithelial cells through inhibition of BK_Ca channels. by Glenn J. Rapsinski (6619841)

Cardiac adherent proliferating cells increase T regulatory cells, increase apoptotic CD4 and CD8 T cells, and decrease apoptotic T regulatory cells in Coxsackievirus B3-infected mi... by Kapka Miteva (192634)

Mean change in time spent with male ‘X’ in phase 1 vs phase 2 of expt. I. by Ronald David MacLaren (5220818)

“…<p>Mean change in total time (± SE) spent with male ‘X’ in phase 1 (in which no model female was used) vs phase 2 (wherein a model female was initially paired with the smaller male) in expt. …”

Onset of nilotinib resistance in K562 and K562-Dox cells coincides with ABCB1 overexpression; ABCB1 levels decrease upon continued high dose nilotinib exposure. by Laura N. Eadie (3044079)

(a) Geographic Location of China (Map sourced from the Ministry of Natural Resources of China, Carto-graphic License: GS (2019)1659); (b) Geographic Location of Xinxiang City; (c)... by Yichuan Zhang (2888345)

Absolute long-term trends 1901–2000 in mean annual surface air temperature and mean annual total precipitation for the global urban land (per grid cell) and the combined share of n... by Sebastian Scheuer (3142821)

“…<p>(A) Combined trends in mean annual surface air temperature (K) and mean annual total precipitation (mm) that are significant at the 10% level. …”

Cortical morphology of the femur at mid diaphysis (adjusted for bone mass), bone volume fraction (BV/TV) (adjusted for body mass), and trabecular microarchitecture of the distal fe... by Daksh Arora (16510065)

<strong>At-home use of a pregnancy-specific Zone-MPC closed-loop system for pregnancies complicated by type 1 diabetes: a single arm, observational multicenter study</strong> by Carol J. Levy (15369802)

“…</p> <p>Results: Ten participants (HbA1c 5.8±0.6%) used the system from mean gestational age of 23.7±3.5 weeks. …”

L1 overexpressing SENAs show increased neuronal differentiation and neurite outgrowth and decreased astrocytic differentiation after transplantation into the lesioned spinal cord w... by Yi-Fang Cui (227234)

LAG3 deficiency enhances Th1 cells and decrease Treg upon adoptive transfer into wild-type mice followed by <i>E</i>. <i>multilocularis</i> infection. by Dewei Li (2806207)

Effect of Na_V1.1 epileptogenic mutations on the firing of GABAergic neurons: Input-output relationship and action potential amplitude. by Louisiane Lemaire (5044049)

“…<b>B₃</b>: Mean input-output relationships for fast spiking neurons recorded from <i>Scn1a</i>^+/- (<i>n</i> = 7) and wild type littermates (<i>n</i> = 7), the number of elicited action potentials was not different, but depolarization block was induced with lower depolarizing current (the traces in which there was depolarization block were excluded, to avoid the influence of depolarization block in the evaluation of the number of action potentials elicited with larger depolarizing currents). …”

AR-induced downstream signaling cascades were recapitulated in membrane-LRs of HUVECs cells, upon KSHV infection. by Xing Wang (154377)

“…<p>(a, b) PP1-induced decreasing expression of pEphA2 at Ser897 is rescued by DHT treatment upon KSHV infection. …”

Overtrained mice show reduced signaling capacity of DLS mGluR1/5 in response to a change in the prevailing A–O contingency. by Vincent Paget-Blanc (21807763)

DataSheet_1_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.zip by Xiao-yang Gong (13103400)

“…Due to the small number of patients in this study, these differences need to be further validated in a larger cohort.</p>…”