cART treatment of SweAPP N2a cells promotes mitochondrial dysfunction. by Lecia A. M. Brown (554752)

“…We found a significant decrease in ATP levels in cells treated with EFV or 3TC/AZT/EFV (***<i>P</i><0.001). …”

The gut microbiota is involved in intestinal homeostasis. by Chengyao Li (311264)

MRP3 silencing led to reduce excretion rates and increase intracellular demethoxycurcumin-<i>O</i>-glucuronides in HeLa1A1 cells. by Beibei Zhang (509356)

“…<p>(A) MRP3 transporter silencing inhibited the accumlated demethoxycurcumin-<i>O</i>-glucuronides (G1) in extracellular medium; (B) MRP3 transporter silencing decreased the excreted demethoxycurcumin-<i>O</i>-glucuronides (G2) in extracellular solution; (C) MRP3 silencing significantly reduced the excretion rates of G1 and G2; (D) MRP3 silencing resulted in evaluation of intracellular G1 and G2 levels; (E) MRP3 silencing decreased total cellular glucuronidation (G1 ang G2) of demethoxycurcumin; (F) Effects of gene silencing on the protein level of MRP3. …”

Ca²⁺-sensitive cameleon YC3.60 ratiometric imaging shows that [Ca²⁺]_cyt levels are decreased and less steady in growing <i>rbohH-1 rbohJ-2</i> poll... by Aurélien Boisson-Dernier (490023)

Efficacy and Safety of OnabotulinumtoxinA in Patients with Neurogenic Detrusor Overactivity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Tao Cheng (1235148)

“…The onabotulinumtoxinA-treated groups had a significantly decreased mean number of urinary incontinence episodes per week (at week 6) (onabotulinumtoxinA200U: MD: -10.72, 95% CI: -13.4 to -8.04, P<0.00001; 300 U: MD: -11.42, 95% CI: -13.91 to -8.93, P<0.00001), MDP (200 U: MD: -33.46, 95% CI: -39.74 to -27.18, P<0.00001; 300 U: MD: -31.72, 95% CI: -37.69 to -25.75, P<0.00001), and greater increased MCC (200 U: MD: 141.30, 95% CI: 121.28 to 161.32, P<0.00001; 300 U: MD: 151.39, 95% CI: 130.43 to 172.34, P<0.00001) compared to the placebo-treated groups. …”

Comparison of the changes in HR (A), SBP (B), DP (C), and SpO2 (D) during maximal exercise test among the three oxygen conditions. by Kazufumi Hisamoto (21416905)

Effects of levofloxacin on the hind paws of DBA/1 mice. by Susana Aideé González-Chávez (11495378)

Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021 by Stein Emil, Vollset

“…Forecasts for the reference scenario found that health will improve in the coming decades, with all-cause age-standardised DALY rates decreasing in every GBD super-region. The total DALY burden measured in counts, however, will increase in every super-region, largely a function of population ageing and growth. …”
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Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021 by Stein Emil, Vollset

“…Forecasts for the reference scenario found that health will improve in the coming decades, with all-cause age-standardised DALY rates decreasing in every GBD super-region. The total DALY burden measured in counts, however, will increase in every super-region, largely a function of population ageing and growth. …”
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CF-BECs infected with 2 x 10² CFU’s of PA demonstrate significant bacterial burden at 24 hours without affecting monolayer confluency. by Meghan J. Hirsch (16528311)

Transporter inhibitor MK571 inhibited the generation and excretion of demethoxycurcumin-<i>O</i>-glucuronides in HeLa1A1 cells. by Beibei Zhang (509356)

“…<p>(A) MK571 (5 and 20 μM) inhibited the excretion of demethoxycurcumin-<i>O</i>-glucuronides (G1) in extracellular medium; (B) Inhibitory effects of MK571 (5 and 20 μM) on the excretion of demethoxycurcumin-<i>O</i>-glucuronides (G2) in extracellular solution; (C) MK571 (5 and 20 μM) decreased the efflux excretion rates of G1 and G2; (D) MK571 (5 and 20 μM) evaluated the intracellular levels of G1 and G2; (E) MK571 (5 and 20 μM) reduced the overall formation (<i>f</i>_met) of G1 and G2 in HeLa1A1 cell; The concentration of demethoxycurcumin was 4 μM. …”

Depletion of <i>gon-1</i> causes INS-18 secretion defects. by Sawako Yoshina (375229)

Clodrolip decreases the number of collagen-producing cells and the mRNA expression of the fibroblast markers <i>vimentin</i> and <i>P4hb</i> in BCC-bearing skin of <i>Ptch<sup>flox... by Simone König (67827)

Depletion of <i>gon-1</i> causes DAF-7 secretion defects. by Sawako Yoshina (375229)

Effects of ESE-16 on ROS and lysosomal activity in MDA-MB-231, MCF-7 and MCF-12A cells after 24 h exposure. by Barend Andre Stander (108706)

“…<p>Relative mean fluorescence intensity of DCF (FL1) (A) hydroethidine (FL3) (B) in MCF-7, MDA-MB-231 and MCF-12A cells exposed to ESE-16 (200 nM). …”

Depletion of <i>gon-1</i> causes DAF-28 secretion defects. by Sawako Yoshina (375229)

The mean number of spiral waves, averaged over 200 initial conditions 〈<i>N</i>_spiral〉_IC is shown for both models. by Marcel Aron (7321247)

Effects of levofloxacin on the spines of DBA/1 mice. by Susana Aideé González-Chávez (11495378)

A novel SNP of <i>MYO1A</i> gene associated with heat-tolerance in Chinese cattle by Yanhong Cao (428443)

“…Further analysis showed that frequency of wild allele A decreased gradually from northern cattle to southern cattle, whereas frequency of mutant type allele G showed the opposite pattern, which was consistent with the distribution of various climatic conditions of China. …”

Integrin and RNF31 binding to SHARPIN are mutually exclusive. by Nicola De Franceschi (4518478)

“…(B) Co-immunoprecipitation of endogenous SHARPIN, RNF31 and ITGAL from Jurkat cells (a GFP antibody was used as negative control). (C) Pull-down of GFP-SHARPIN from HEK293 cells demonstrated that cells in suspension show decreased RNF31-SHARPIN interaction compared to adherent cells (n = 4). …”