KDM6A addiction is caused by the HPV E7 protein. by David R. Soto (4484626)

“…KDM6A was depleted in HFKs expressing control vector, HPV16 E7, E6, or E6 and E7; <i>(C)</i> Cell viability was measured by reduction of resazurin; <i>(D)</i> HPV E7 expression was verified by quantitative real-time RT-PCR and compared to levels found in SiHa and CaSki cervical carcinoma cells; <i>(E)</i> Due to the absence of appropriate antibodies, HPV16 E6 expression was determined by assessing p53 levels, which are decreased in HPV16 E6-expressing cells because of E6-mediated proteasomal degradation [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006661#ppat.1006661.ref066" target="_blank">66</a>], by Western blot analysis of p53. …”

Association of Hypoxia-Inducible Factor-2 Alpha Gene Polymorphisms with the Risk of Hepatitis B Virus-Related Liver Disease in Guangxi Chinese: A Case-Control Study by Liling Huang (1627294)

“…</p><p>Conclusions</p><p>The HIF-2a rs13419896 polymorphism is associated with an increased risk of CHB and LC in the Guangxi Chinese population, especially in females and in the non-alcohol-drinking population, while the HIF-2a gene rs6715787 polymorphism is associated with a decreased risk of LC in the Guangxi Zhuang population.…”

Analysis of the ¹ H–¹⁵N HSQC spectrum of the RAGE V domain with unlabeled S100A1. by Md. Imran Khan (4853302)

“…Cross-peaks displaying significantly decreased intensity are shown in green boxes.</p> <p>(B) Bar graph analysis representing the intensity change (I/I₀) of cross-peaks of ¹⁵N V domain to ¹⁵N V domain complex with S100A1 versus residue numbers of RAGE V domain (24–128). …”

Analysis of the ¹H–¹⁵N HSQC spectra of S100A1 in complex with the unlabeled RAGE V domain. by Md. Imran Khan (4853302)

“…The blue line represents the criterion of selected residues that exhibit a significantly decreasing cross-peak signal, and the chosen residues are displayed in red bars.…”

Fetuin-A expression in the cerebellum of inflammatory cases (n = 17) and controls (n = 14). by Miriam Christina Heinen (5949740)

“…<p>(Displayed are mean ± SE individual scores for each case.) Fetuin-A immunoreactivity was generally decreased in inflammation, reaching statistical significance in the case of Purkinje cells (**p = 0.001). …”

A summary of chemotaxis plasticity induced by sugar and salt conditioning. by Masahiro Tomioka (430683)

“…<p>The ASEL neuron responds to a decrease in glucose concentration and increases the forward locomotion probability in naive animals grown without glucose, thereby promoting glucose avoidance (left, Naive). …”

Analysis of the ¹H–¹⁵N HSQC spectra of S100B in complex with the unlabeled S100A1. by Md. Imran Khan (4853302)

“…<p>(A) Overlapped NMR HSQC spectra of ¹⁵N-S100B in black and ¹⁵N labeled S100B complex with unlabeled S100A1 in a 1:1M ratio (red). …”

Data of AFR(%) of axial surface for each group. by Long Li (6555)

Subjects:

Comparison of heart rate (HR) response during high-intensity interval exercise (dotted line) vs. continuous exercise (full line) for mean exercise intensities A, B, and C. by Othmar Moser (789838)

Comparison of blood lactate response (La) during high-intensity interval exercise (dotted line) vs. continuous exercise (full line) for mean exercise intensities A, B, and C. by Othmar Moser (789838)

The Role of Genetically Modified Mesenchymal Stem Cells in Urinary Bladder Regeneration by Devon C. Snow-Lisy (798898)

“…At 4 weeks post-surgery, data demonstrated increased vessel number (~250 vs ~109 vessels/mm²) and bladder smooth muscle content (~42% vs ~36%) in Cyr61OX (over-expressing) vs Cyr61KD (knock-down) groups. Muscle content decreased to ~25% at 10 weeks in Cyr61KD groups. Wnt5aOX resulted in high numbers of vessels and muscle content (~206 vessels/mm² and ~51%, respectively) at 4 weeks. …”

Omentin-1 in diabetes mellitus: A systematic review and meta-analysis by Xiongfeng Pan (5825465)

“…<div><p>Objective</p><p>Previous studies found inconsistent results on the relationship between diabetes mellitus and concentrations of omentin-1. This study performed a systematic review and meta-analysis to summarize previous findings on this relationship.…”

Lateral (3-A) and medial (3-B) views of the cortical mineralization. by Natsuko Hichijo (752937)

Lateral view of a reconstructed right hemimandible showing the volumes of interest. by Natsuko Hichijo (752937)

Increased endothelial cell-cell junction size on stiff matrices is diminished after simvastatin treatment. by Marsha C. Lampi (845609)

“…<p>Endothelial monolayers are stained for VE-cadherin and cell-cell junction sizes are measured with control and 1 μM simvastatin treatments. (A) Representative images of fluorescently stained VE-cadherin monolayers indicating where junction width measurements were made (black line). …”

Simvastatin reduces vinculin localization at cell-cell adhesions in endothelial monolayers. by Marsha C. Lampi (845609)

“…(C) Vinculin localization per monolayer at cell-cell adhesions, a readout of intercellular junction tension, is quantified and increases with matrix stiffness but is significantly decreased with the statin treatment at higher matrix stiffnesses (n = 3, 70–90 fields of view per condition). …”

Biofilm formation assays. by Zezhang T. Wen (135862)

“…The results demonstrate that PBP1a-deficiency significantly decreased biofilm formation by the deficient mutant (* indicates differences at <i>P</i><0.001 when compared to the wild-type, UA159 under the same conditions). …”

Simvastatin alters actin organization, cell morphology, and Rac1 activity in endothelial monolayers. by Marsha C. Lampi (845609)

“…Cell circularity, where a perfectly circular cell has a value of 1, decreases with increasing simvastatin concentration (n = 3, 50–54 cells per condition). …”

Canonical and Noncanonical Sites Determine NPT2A Binding Selectivity to NHERF1 PDZ1 by Tatyana Mamonova (753968)

“…Experimentally introduced mutation in PDZ1 (Glu43Asp and His27Asn) decreased binding to NPT2A. Conversely, introduction of Asp183Glu and Asn167His mutations in PDZ2 promoted the formation of favorable interactions yielding micromolar <i>K</i>_Ds. …”

Ten years of improving glycemic control in pediatric diabetes care: Data from the Norwegian Childhood Diabetes Registry by Heiko Bratke (10112600)

“…The predictor variables in the adjusted linear mixed-effects model were (1) the use of diabetes technology, (2) the use of carbohydrate counting for meal bolusing, and (3) whether the patient’s diabetes team participated in a quality improvement project.</p><p dir="ltr">Results: Mean HbA1c decreased from 8.2% (2013) to 7.2% (2021), and the proportion of youth reaching an HbA1c <7.0% increased from 13% (2013) to 43% (2022). …”