High Fat Diet Subverts Hepatocellular Iron Uptake Determining Dysmetabolic Iron Overload by Paola Dongiovanni (300534)

“…Aims of this study were to assess the effect a high-fat diet (HFD) on hepatic iron metabolism in an experimental model in rats, to further characterize the effect of free fatty acids on iron metabolism in HepG2 hepatocytes <i>in vitro</i>, and to assess the translational relevance in patients with fatty liver with and without iron accumulation. …”

Table1_Geochemistry of Formation Water and Its Implications for Petroleum Source Rocks in the Fengcheng Formation, Mahu Depression, Xinjiang, China.xlsx by Jian Wang (5901)

“…From the first member to the third member of the formation, the salinity first increases and then decreases. This low-high-low trend corresponds to the initial stage of alkaline lake development followed by strong alkali formation and a final stage of water retreat. …”

Table3_Assessment of CircRNA Expression Profiles and Potential Functions in Brown Adipogenesis.XLSX by Pengpeng Zhang (583380)

“…<p>Brown adipose tissue (BAT) is specialized for energy expenditure, thus a better understanding of the regulators influencing BAT development could provide novel strategies to defense obesity. …”

Natalizumab treatment blocks the traffic and accumulation of SIV infected monocyte/macrophages in the brain. by Jennifer H. Campbell (353635)

“…<p>(A) Natalizumab treatment on 28 dpi (late), resulted in scattered SIV p28⁺ and RNA⁺ cells in the CNS (frontal cortex, parietal cortex, occipital cortex, brainstem) relative to controls, all sacrificed with progression to AIDS. …”

Severe obesity and the impact of medical weight loss on estimated glomerular filtration rate by Amy E Rothberg (8383968)

“…In subjects with severe obesity undergoing medical weight loss, estimating equations that use cystatin C and are indexed to actual BSA may provide a more accurate assessment of renal function.</p><p></p>…”

Image_6_Abnormal Glucose Metabolism in Male Mice Offspring Conceived by in vitro Fertilization and Frozen-Thawed Embryo Transfer.PDF by Ningxin Qin (10115329)

“…It is of great necessity to assess the safety of FET and investigate the long-term effect including glucose metabolism on FET-conceived offspring. The mouse model is a highly efficient method to figure out the relationship between the process of FET and offspring health. …”

DataSheet3_Sanqi Oral Solution Mitigates Proteinuria in Rat Passive Heymann Nephritis and Blocks Podocyte Apoptosis via Nrf2/HO-1 Pathway.zip by Xiaowan Wang (9704207)

“…To investigate the effects of SQ, we established the experimental passive Heymann nephritis (PHN) rat model induced by anti-Fx1A antiserum in vivo and doxorubicin hydrochloride (ADR)-injured apoptotic podocyte model in vitro. …”

Image_4_Splenic SUMO1 controls systemic inflammation in experimental sepsis.jpeg by Ayman Youssef (16537653)

“…In the spleen, endotoxemia induced a distinct temporal and substrate specificity for SUMO1 and SUMO2/3, and both were inhibited by TAK981. …”

Table_5_Alterations of the gut microbiota in patients with immunoglobulin light chain amyloidosis.xlsx by Jipeng Yan (8473710)

“…Notably, 5 optimal ASV-based microbial markers were identified as the diagnostic model of AL amyloidosis and the AUC value of the train set and the test set was 0.8549 (95% CI 0.7310-0.9789) and 0.8025 (95% CI 0.5771-1), respectively. With a median follow-up of 19.0 months, further subgroup analysis also demonstrated some key gut microbial markers were related to disease severity, treatment response, and even prognosis of patients with AL amyloidosis.…”

Tick-Borne Encephalitis Virus Replication, Intracellular Trafficking, and Pathogenicity in Human Intestinal Caco-2 Cell Monolayers by Chao Yu (562804)

“…Concomitantly, viruses were detected in the basolateral medium, implying a transcytosis pathway. When Caco-2 cells were pre-treated with inhibitors of cellular pathways of endocytosis TBEV cell entry was efficiently blocked, suggesting that actin filaments (Cytochalasin) and microtubules (Nocodazole) are important for PI3K-dependent (LY294002) virus endocytosis. …”

Image_1_Wheat F-box Protein TaFBA1 Positively Regulates Plant Drought Tolerance but Negatively Regulates Stomatal Closure.tif by Jie An (543888)

“…In addition, TaFBA1 was found to be a negative regulator of ABA-induced stoma movement; mRNA transcription of certain ABA signaling-related genes was lower in TaFBA1 OE plants than in WT plants following ABA treatment. …”

Table_9_Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk.DOCX by Jiarui Mi (11170284)

“…</p>Results<p>In the primary analysis with 249 traits, we found that plasma triglycerides were positively associated with pancreatitis risk. Intriguingly, a large number of traits associated with saturation or unsaturation of fatty acids also demonstrated causal associations. …”

Supplemental Material for the study: Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease by Anne-Sofie Jensen (18193804)

“…Blood samples were collected during a 120 min oral glucose tolerance test. We measured the concentrations of glucose, C-peptide, insulin, glucagon, the two incretin hormones glucose insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1). …”

Table_1_Calcium-Binding Protein S100P Promotes Tumor Progression but Enhances Chemosensitivity in Breast Cancer.DOCX by Yizi Cong (9377933)

“…</p>Conclusion<p>S100P promotes the aggressive properties of breast cancer cells and may be considered as a promising therapeutic target. Moreover, S100P can be used to predict the therapeutic effect of chemotherapy in HER2+ breast cancer patients.…”

Table2_Improved diagnosis of inflammatory bowel disease and prediction and monitoring of response to anti-TNF alpha treatment based on measurement of signal transduction pathway ac... by Wilbert Bouwman (9534287)

“…Differential diagnosis remains a challenge. Anti-TNFα treatment is an important treatment for IBD, yet resistance frequently occurs and cannot be predicted. …”

Image 1_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.tif by Zhuowen Hu (20431616)

“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”

Image_6_10-Hydroxydec-2-Enoic Acid Reduces Hydroxyl Free Radical-Induced Damage to Vascular Smooth Muscle Cells by Rescuing Protein and Energy Metabolism.TIF by Pei Fan (404125)

“…To the best of our knowledge, our results provide the first concrete evidence that 10-HDA-scavenged •OH could be a potential pharmacological application for maintaining vascular health.…”

Long-term tillage and cover cropping differentially influenced soil nitrous oxide emissions from cotton cropping system by Debasish Saha (17481384)

“…We investigated N₂O emissions in response to 42 years of long-term adoption of NT and legume cover crop, under nitrogen rates of 0 and 67 kg N ha^-1, in a continuous cotton system in the Southeastern US. …”

Image_2_Synergistic and Antagonistic Effects of Biogenic Silver Nanoparticles in Combination With Antibiotics Against Some Pathogenic Microbes.jpg by Kawther Aabed (9674992)

“…The synergistic effects of biogenic AgNPs in combination with some antibiotics support their potential as a safe therapeutic for bacterial infections because they are capped with organic biomolecules.…”

DataSheet1_Vegetable glycerin e-cigarette aerosols cause airway inflammation and ion channel dysfunction.pdf by Michael D. Kim (10153706)

“…Here, we investigated whether VG e-cig aerosols, in the absence of nicotine and flavors, impact parameters of mucociliary function in human volunteers, a large animal model (sheep), and air-liquid interface (ALI) cultures of primary human bronchial epithelial cells (HBECs). …”