Image1_Comprehensive in vitro and in silico assessments of metabolic capabilities of 24 genomic variants of CYP2C19 using two different substrates.TIF by Myung-Eui Seo (6822518)

“…</p><p>Discussion: Therefore, we propose a methodology that combines in silico prediction algorithms and functional assays on polymorphic CYPs with multiple substrates to evaluate the changes in the metabolism of all possible genomic variants in CYP genes. …”

Raw data of indirect ELISAs shown in S5 Fig. by Inga Petersen (9253821)

“…Here, we investigated whether a negatively charged peptide tail fused to the αSyn aggregate-specific antibodies SynO2 and 9E4 could enhance the antibodies’ avidity to αSyn aggregates in order to improve their potential therapeutic effect through inhibiting cell-to-cell spreading and enhancing the clearance of extracellular aggregates. …”

DataSheet7_Sanqi Oral Solution Mitigates Proteinuria in Rat Passive Heymann Nephritis and Blocks Podocyte Apoptosis via Nrf2/HO-1 Pathway.ZIP by Xiaowan Wang (9704207)

“…To investigate the effects of SQ, we established the experimental passive Heymann nephritis (PHN) rat model induced by anti-Fx1A antiserum in vivo and doxorubicin hydrochloride (ADR)-injured apoptotic podocyte model in vitro. …”

Table_1_Identification of subclusters and prognostic genes based on glycolysis/gluconeogenesis in hepatocellular carcinoma.docx by Dan Chen (32468)

“…The study also identified five intersecting DEGs from candidate genes in TCGA, GSE14520, and GSE141198 as prognostic genes, which had a protective role in HCC patient prognosis. Compared with the control group, the prognostic genes all showed decreased expression in HCC patients in RT-qPCR and Western blot analyses. …”

IGF-II promotes an intracellular and an extracellular fibrotic environment. by Sara M. Garrett (8038460)

“…<p>Transcript levels of <i>TIMP1</i> (A), <i>TIMP4</i> (B), and <i>MMP3</i> (C) normalized to <i>GAPDH</i> housekeeping gene by qRT-PCR and secreted TIMP1 (D), TIMP4 (E), and MMP3 (F) levels in supernatant by ELISA in NL, IPF, and SSc fibroblasts treated with vehicle (PBS) or IGF-II (200 ng/mL) for 48 hr. …”

DataSheet1_Single-cell transcriptome dynamics of the autotaxin-lysophosphatidic acid axis during muscle regeneration reveal proliferative effects in mesenchymal fibro-adipogenic pr... by Osvaldo Contreras (780538)

“…<p>Lysophosphatidic acid is a growth factor-like bioactive phospholipid recognising LPA receptors and mediating signalling pathways that regulate embryonic development, wound healing, carcinogenesis, and fibrosis, via effects on cell migration, proliferation and differentiation. …”

DataSheet_1_Difference of Intrahost Dynamics of the Second Human Pegivirus and Hepatitis C Virus in HPgV-2/HCV-Coinfected Patients.xlsx by Yuanhao Liang (8494716)

“…The different genetic diversity of HPgV-2 and HCV makes HPgV-2 a potential new model to investigate RNA virus diversity and the mechanism of viral polymerase in modulating virus replication.…”

Seizure number, cumulative duration, and EEG power attenuation in rats treated with phenobarbital and bumetanide. by Ryan T. Cleary (387997)

“…<p>The number of hypoxia-induced seizures (A), and cumulative seizure duration (B) were plotted for each treatment group. …”

Inhibitory Effect of Tanshinone IIA on Rat Hepatic Stellate Cells by Ya-Wei Liu (606320)

“…Tanshinone IIA (C₁₉H₁₈O₃, Tan IIA) is a lipophilic diterpene isolated from <i>Salvia miltiorrhiza</i> Bunge, with reported anti-inflammatory activity. …”

Image1_Treadmill training does not enhance skeletal muscle recovery following disuse atrophy in older male mice.pdf by Elena M. Yee (14852698)

“…<p>Introduction: A hallmark of aging is poor muscle recovery following disuse atrophy. …”

Data Sheet 1_Clinical characteristics and outcome of very old (≥90 years) critically ill patients with need for intensive care after surgical intervention.docx by Jöran Lücke (14948623)

“…Background<p>Due to increasing life expectancy and decreasing morbidity, society is aging. Especially the group of very old patients (≥90 years) is currently increasing significantly. …”

Image_2_Change of mortality of patients with acute ischemic stroke before and after 2015.TIF by Sang-Won Park (180226)

“…</p>Materials and methods<p>A retrospective cohort study was conducted using combined anonymized data from the Acute Stroke Assessment Registry of Korea and the Health Insurance Review & Assessment Service database. …”

Characterization of the <i>Per1</i>::<i>luc</i> circadian rhythm in BMSCs. by Nathaniel Hassan (4373695)

“…<p>All the luminometry experiments were performed in triplicate for each group. <b>A</b>. The baseline-subtracted luminometry data demonstrated the steady circadian expression of <i>Per1</i>::<i>luc</i> of BMSC, which progressively decreased over the culture period. …”

Image_1_Synergistic and Antagonistic Effects of Biogenic Silver Nanoparticles in Combination With Antibiotics Against Some Pathogenic Microbes.jpg by Kawther Aabed (9674992)

“…The synergistic effects of biogenic AgNPs in combination with some antibiotics support their potential as a safe therapeutic for bacterial infections because they are capped with organic biomolecules.…”

Image_6_Insights Into the MYB-Related Transcription Factors Involved in Regulating Floral Aroma Synthesis in Sweet Osmanthus.JPEG by Xin Yan (17064)

“…In this study, we conducted a genome-wide analysis of MYB-related proteins in sweet osmanthus; 212 OfMYB-related TFs were divided into three distinct subgroups based on the phylogenetic analysis. …”

Data_Sheet_1_Molecular Features of Polycystic Ovary Syndrome Revealed by Transcriptome Analysis of Oocytes and Cumulus Cells.xlsx by Jie Li (15030)

“…<p>Polycystic ovary syndrome (PCOS) is typically characterized by a polycystic ovarian morphology, hyperandrogenism, ovulatory dysfunction, and infertility. …”

image2_Effect of Hydrolyzed Bird’s Nest on β-Cell Function and Insulin Signaling in Type 2 Diabetic Mice.tif by Ker Woon Choy (4057168)

“…In the present study, the effect of standardized aqueous extract of hydrolyzed edible bird nest (HBN) on metabolic characteristics and insulin signaling pathway in pancreas, liver and skeletal muscle of db/db, a type 2 diabetic mice model was investigated. …”

Table_3_Carbon Amendments Influence Composition and Functional Capacities of Indigenous Soil Microbiomes.XLSX by José Pablo Dundore-Arias (6517574)

“…Mesocosms were established with soil from two field sites varying in soil organic matter content (low organic matter, LOM; high organic matter, HOM), that were amended at intervals over nine months with low or high dose solutions of glucose, fructose, malic acid, a mixture of these compounds, or water only (non-amended control). …”

Data_Sheet_5_ZmPP2C26 Alternative Splicing Variants Negatively Regulate Drought Tolerance in Maize.XLSX by Fengzhong Lu (12373204)

“…In this study, we characterized a clade B member of maize PP2C family, i.e., ZmPP2C26, that negatively regulated drought tolerance by dephosphorylating ZmMAPK3 and ZmMAPK7 in maize. …”

Table 1_Feeding citrus pomace fermented with combined probiotics improves growth performance, meat quality, fatty acid profile, and antioxidant capacity in yellow-feathered broiler... by Yanchen Liu (3691888)

“…This study was aimed to investigate the effects of feeding citrus pomace (CP) fermented with combined probiotics on growth performance, carcass traits, meat quality and antioxidant capacity in yellow-feathered broilers.</p>Methods<p>A cohort of 540 female yellow-feathered broilers (Qingyuan partridge chicken, 90-day-old) were randomly divided into three groups and, respectively, fed the basal diet (Control), diet containing 10% unfermented CP (UFCP) and diet containing 10% fermented CP (FCP).…”