BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain by Jia-Jie Teoh (3929852)

“…<i>In vitro</i>, BIG1-deficient neurons showed a delay in neuronal polarization. BIG1-deficient neurons were also hypersensitive to low dose glutamate (5 μM), and died via apoptosis. …”

Image1_Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice.TIF by Lu Xia (1509745)

“…</p><p>Conclusion: GSDMD-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures. Our study provides a new potential therapeutic target for seizure control.…”

Abnormal expression of Nrf2 may play an important role in the pathogenesis and development of adenomyosis by Ning Chen (127610)

“…Specified reduction of Nrf2 expression could prove to be a new therapeutic target in the clinical treatment of adenomyosis.…”

Data_Sheet_1_High blood viscosity in acute ischemic stroke.PDF by Jihoon Kang (816884)

“…This finding was consistent at different oscillatory frequencies (134.2 ± 46.3 vs. 102.4 ± 47.2 at 1 rad/sec and 39.2 ± 11.5 vs. 30.4 ± 12.4 at 5 rad/sec, Ps < 0.001), suggesting a relationship between decreases in viscosity and shear rate. …”

Image_2_Antimicrobial potency, prevention ability, and killing efficacy of daptomycin-loaded versus vancomycin-loaded β-tricalcium phosphate/calcium sulfate for methicillin-resista... by Xin Zhang (35492)

“…Our study demonstrated that vancomycin + gentamicin and daptomycin + gentamicin loaded with β-tricalcium phosphate/calcium sulfate or calcium sulfate showed similar prophylactic and killing effects on MRSA biofilms, implying a potential indication of local administration daptomycin for the treatment of MRSA-associated osteoarticular infections, especially if vancomycin administration presents limitations.…”

Air Pollutant Emission Inventory of Waste-to-Energy Plants in China and Prediction by the Artificial Neural Network Approach by Wenchao Ma (3393713)

“…This study provides data and model support for the formulation of appropriate WTE plans and a pollutant emission control scheme in different economic regions.…”

Functional fitness in older women from southern brazil: normative scores and comparison with different countries by Gislaine Cristina Vagetti (5762195)

“…This study proposed normative functional fitness scores for a sample of elderly women from southern Brazil and compared values to their counterparts in the US, Extremadura (Spain), Taiwan (China) and Spain. …”

Supplementary file 1_Translocator protein deficiency blocks the ferroptosis of malignant peripheral nerve sheath tumors through glutathione peroxidase 4.pdf by Xiaoli Zhang (135098)

“…</p>Conclusion<p>Our findings revealed that TSPO deficiency inhibited ferroptosis in MPNST cells by upregulating GPX4 antioxidant pathway, suggesting that mitochondrial TSPO-GPX4-ferroptosis axis may be a promising therapeutic target for improving the outcomes of patients with MPNST.…”

Table_7_Insights Into the MYB-Related Transcription Factors Involved in Regulating Floral Aroma Synthesis in Sweet Osmanthus.docx by Xin Yan (17064)

“…In this study, we conducted a genome-wide analysis of MYB-related proteins in sweet osmanthus; 212 OfMYB-related TFs were divided into three distinct subgroups based on the phylogenetic analysis. …”

Data_Sheet_1_Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury.pdf by Alexey Pronin (556717)

“…Our results showed a complex spatio-temporal pattern of innate immune responses in the retina. …”

Table_1_Integrative Analysis of LGR5/6 Gene Variants, Gut Microbiota Composition and Osteoporosis Risk in Elderly Population.DOCX by Dong-sheng Di (11634688)

“…The rs10920362 CT/TT genotype associated with a decreased relative abundance of Actinobacteria (β = −1.32, P < 0.001), Bifidobacteriaceae (β = −1.70, P < 0.001), and Bifidobacterium (β = −1.70, P < 0.001) compared to the CC genotype.…”

Data_Sheet_11_Effects of Cultured Root and Soil Microbial Communities on the Disease of Nicotiana tabacum Caused by Phytophthora nicotianae.PDF by Tianbo Liu (1390855)

“…In the field experiment, the root functional microflora (RFM) showed a greater suppressiveness of black shank than the soil functional microflora (SFM), while both RFM and SFM altered diversity, composition, structure, and interaction of soil bacterial communities during plant growth. …”

M₁/M₄‑Preferring Muscarinic Cholinergic Receptor Agonist Xanomeline Reverses Wake and Arousal Deficits in Nonpathologically Aged Mice by Jason K. Russell (14467955)

“…The purpose of the present study was to provide the first assessment of the effects of the direct-acting M₁/M₄-preferring muscarinic cholinergic receptor agonist xanomeline on sleep/wake architecture and arousal in young and nonpathologically aged mice, in comparison with the AChEI donepezil, when dosed in either the active or inactive phase of the circadian cycle. Xanomeline produced a robust reversal of both wake fragmentation and disruptions in arousal when dosed in the active phase of nonpathologically aged mice. …”

Table1_Insulin-like peptide 8 (Ilp8) regulates female fecundity in flies.XLSX by Haomiao Li (2743693)

“…</p><p>Discussion: Our findings support a universal role of insect Ilp8 in female fecundity, and also provide novel clues for understanding the modes of action of Ilp8.…”

Data_Sheet_1_Effect of the Boron Concentration in Irrigation Water on the Elemental Composition of Edible Parts of Tomato, Green Bean, Potato, and Cabbage Grown on Soils With Diffe... by Márk Rékási (10966542)

“…The data on the effect of B on the elemental composition in the edible parts of vegetables are scarce. A greenhouse pot experiment investigated the effect of irrigation water containing 0.1 and 0.5 mg/L B on the biomass, elemental (e.g., B, Mg, K, Fe, Cu, and Zn) composition, and photosynthetic parameters of tomato (Solanum lycopersicum), green bean (Phaseolus vulgaris), potato (Solanum tuberosum), and cabbage (Brassica oleracea) plants grown on 10 kg of sand, silty sand, or silty soil. …”

The effects of pravastatin on the normal human placenta: Lessons from <i>ex-vivo</i> models by Adelina Balan (3749380)

“…This data is reassuring and important for clinicians that consider the treatment of high-risk patients with pravastatin, a treatment that exposes some normal pregnancies to the drug.…”

Table3_Insulin-like peptide 8 (Ilp8) regulates female fecundity in flies.XLS by Haomiao Li (2743693)

“…</p><p>Discussion: Our findings support a universal role of insect Ilp8 in female fecundity, and also provide novel clues for understanding the modes of action of Ilp8.…”

Image_4_Modulation of intestinal IL-37 expression and its impact on the epithelial innate immune response and barrier integrity.tif by Laura Kröhn (17011479)

“…However, higher IL37 expression correlated with a reduced proinflammatory cytokine response in murine colonic organoids. …”

DataSheet1_Degradation of 17 Benzodiazepines by the UV/H2O2 Treatment.docx by Wen-Dan You (11579059)

“…The degradation of alprazolam, a typical benzodiazepine, during the UV/H₂O₂ treatment was increased with the increasing H₂O₂ dosage. …”

Role of SIRT-2 in the endotoxin tolerant RAW cells. by Xianfeng Wang (120153)

“…<p><u>A: RAW cells undergo endotoxin tolerance as early as 4h after LPS stimulation:</u> To study endotoxin tolerance in RAW cells, we stimulated cells with LPS (100ng/ml) and re-stimulated with another LPS challenge (100ng/ml) at 0, 4, 6, 8, and 24 hour time points for four hour. …”