Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK... by Yapeng Li (124282)

“…In the present study, using fasudil which is a specific inhibitor of ROCK, we aimed to investigate whether improved SERCA expression and activity accounts for reduced ER stress by ROCK inhibition, specifically whether PI3K/Akt and JAK2/STAT3 pathways are differentially involved in modulating SERCA activity to reduce ER stress and hence I/R injury. …”

Image_7_Wheat F-box Protein TaFBA1 Positively Regulates Plant Drought Tolerance but Negatively Regulates Stomatal Closure.tif by Jie An (543888)

“…In addition, TaFBA1 was found to be a negative regulator of ABA-induced stoma movement; mRNA transcription of certain ABA signaling-related genes was lower in TaFBA1 OE plants than in WT plants following ABA treatment. …”

Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women by Vijay, Ganji

“…In multivariable adjusted analysis, no association was found between serum 25(OH)D concentration and bone mass when serum 25(OH)D was categorized. In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. …”
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CB2R inhibits the production of IL-1β but not IL-6 and TNF-α in cultured peritoneal macrophages stimulated with LPS/DSS. by Ping Ke (3110763)

“…The levels of IL-1β, IL-6 and TNF-α were measured by ELISA. (A-C) Pre-incubated with HU 308 significantly decreased the level of IL-1β but have no effect on the levels of IL-6 and TNF-α. n = 6 per group. …”

<i>Foxo</i> mediates the effects of <i>PI3K</i> on motor neuron excitability. by Eric Howlett (268817)

“…For all LTF experiments, the bath solution contained 0.15 mM [Ca²⁺] and 100 µM quinidine. A) Representative traces showing the decreased rate of onset of LTF (I) and decreased ejp amplitude (II) in <i>Foxo²¹/Foxo²⁵</i> larvae compared to wildtype at the indicated [Ca²⁺], and the increased rate of onset of LTF and ejp amplitude in larvae overexpressing <i>Foxo</i>. …”

Quantitative scoring of collagen II, MMP-13 and ICAM-1 immunohistochemistry. by Julia Lorenz (626379)

“…<p>Medial parts of frontal sections of right knee joints from WT and Mc1re/e mice of non-operated (non-op) 11 weeks old and 6 months old animals, and of mice 4 and 8 weeks after osteoarthritis induction (post operation (p.o.)) were scored after staining. 1-3 sections of right knees (DMM) were scored histological according to the scoring system illustrated in Tab. 1 for collagen II, in Tab. 2 for MMP-13 and in Tab. 3 for ICAM-1 staining. A) Compared to non-operated controls collagen II stained cartilage area of WT knee joints is decreased 4 weeks (p = 0.0079) and 8 weeks (p = 0.0043) after OA-induction as well as in non-operated 6 month old animals (p = 0.0159). …”

Safety profile of proprotein convertase subtilisin/kexin type 9 inhibitors alirocumab and evolocumab: an updated meta-analysis and meta-regression by Frederick Berro Rivera (12679463)

Deletion of <i>Foxm1</i> from macrophages increases expression of pro-fibrotic cytokines without affecting number of myeloid cells. by Chinmayee Goda (8694597)

“…<p><b>(A)</b><i>Foxm1</i> mRNA levels were decreased in BALF cells isolated from bleomycin-treated my<i>Foxm1</i>^-/- lungs as determined by qRT-PCR. …”

Genetic interaction analysis of <i>alfa-1</i>(<i>ok3062</i>) with <i>daf-2</i>(<i>e1370</i>) or <i>daf-16</i>(<i>mu86</i>). by Yon Ju Ji (3359057)

“…<p>(A) Brood size analysis of <i>alfa-1(ok3062)</i>. …”

Antigen processing and presentation responses for Neutrophils and NK-cells showed increased MHC-II sub-pathway activity that differed between vaccine groups. by Leigh M. Howard (694627)

“…<p><b>(A)</b> Neutrophil responses. <b>(B)</b> NK-cell responses. …”

T cell phenotypic analysis by multiparametric flow cytometry. by Raianna F. Fantin (11636672)

“…<p>Bar graphs show percentage of CD3⁺ T cells (a) CD3+CD56^-CD4⁺ T cells (b) and CD3⁺CD56^-CD8⁺ T cells (c) from total Live PBMCs. …”

Data_Sheet_1_Spatial-temporal clustering of an outbreak of SARS-CoV-2 Delta VOC in Guangzhou, China in 2021.docx by Qian Zhang (49333)

“…</p>Results<p>The result of the Knox analysis showed that the areas at short distances and brief periods presented a relatively high risk. The strength of clustering of male-male pairs was higher. …”

DataSheet_1_Application of Diffusion Kurtosis Imaging in Evaluating Acute Xerostomia in Nasopharyngeal Carcinoma Treated With Induction Chemotherapy Plus Concurrent Chemoradiothera... by Da-Wei Zhao (1753762)

“…</p>Conclusion<p>DKI is a promising tool for tracking and monitoring the acute damage of PG, SMG, and SLG induced by IC+CCRT in NPC patients.…”

Sequences of forward and reverse primers. by Yao-Yao Mao (22693684)

“…<div><p>Background</p><p>Clinical practice commonly uses the Yi-qi Huo-xue formula (YQHX), a traditional Chinese herbal medicine comprising eight herbal components, to treat liver fibrosis resulting from various etiologies. …”

Presentation_1_Astragaloside IV Protects 6-Hydroxydopamine-Induced SH-SY5Y Cell Model of Parkinson’s Disease via Activating the JAK2/STAT3 Pathway.PPTX by ZhengHu Xu (10347746)

“…Parkinson’s disease (PD) is a common neurodegenerative disease. This study explored the protective effect of AS-IV on the cell model of PD.…”

DataSheet1_Biochemical characterization of L-asparaginase isoforms from Rhizobium etli—the boosting effect of zinc.pdf by Joanna Sliwiak (18006655)

“…The activity of ReAIV has a temperature optimum at 45°C–55°C, whereas the activity of ReAV, after reaching its optimum at 37°C, decreases dramatically at 45°C. …”

Simplified working model of PGE₂-stimulated Cl^- and HCO₃^- secretion and mucociliary clearance in non-CF and CF airway. by Zachary M. Sellers (4720869)

“…<p><b>A.</b> In the airway, microbial infections cause an increase in PGE₂ through release from infiltrating inflammatory cells (not pictured) and production by airway epithelia <i>via</i> COX-2 activation. …”

Data_Sheet_1_Global, regional, and national temporal trends in mortality and disability-adjusted life years for cardiovascular disease attributable to low temperature during 1990–2... by Xiaofei Li (334285)

“…Both high CVD mortality (19.45, 95% CI [14.54, 24.17%]) and a decreasing mortality rate related to low temperature (from 1990 to 2019, net drift, −3.25% [−3.76, 2.73%] per year) was found in high SDI countries or territories, with opposite outcome found in low SDIs regions. …”

DataSheet_1_Sepsis causes neutrophil infiltration in muscle leading to muscle atrophy and weakness in mice.docx by Nobuto Nakanishi (8069483)

“…These results suggest that neutrophils may play a critical role in sepsis-induced muscle atrophy and weakness.…”

List of study outcomes. by Madison Hooper (17008490)

“…<div><p>Importance</p><p>The COVID-19 pandemic represents a unique stressor in Americans’ daily lives and access to health services. …”