Detection of apoptosis after cytoskeletal disruption in wild type and MEKK1-deficient cell lines. by Erin Tricker (355544)

“…<p><i>A</i>. DNA laddering is significantly decreased in the <i>MEKK1^−/−</i> DT40 and murine pre-B cell lines upon treatment with vinblastine, cytochalasin D, and okadaic acid, whereas the response to etoposide is unchanged. …”

Image_3_Deletion of Non-histidine Domains of Histidine Kinase CHK1 Diminishes the Infectivity of Candida albicans in an Oral Mucosal Model.TIF by Yahui Feng (3897082)

“…</p>Methods<p>The domain mutants CHK25 (^ΔS_TkcCHK1/Δchk1) and CHK26 (^ΔS_TkcΔgafCHK1/Δchk1) were first constructed by the his1-URA3-his1 method and confirmed by sequencing and Southern blots. A mouse tongue infection model was used to evaluate the hyphal invasion and fungal loads in each domain mutant, full-gene deletion mutant CHK21 (chk1Δ/chk1Δ), re-constituted strain CHK23 (chk1Δ/CHK1), and wild type (WT) from day 1 to day 5. …”

Image_1_Macrophages-Related Genes Biomarkers in the Deterioration of Atherosclerosis.TIFF by Yue Zheng (601811)

“…The hub DEMRGs and their interactions were analyzed using NetworkAnalyst 3.0 and for validation, the expressions of hub DEMRGs were analyzed using the GSE135055 and GSE116250 datasets as well as atherosclerosis and MI mice model.</p>Results<p>A total of 509 differentially expressed genes (DEGs) were correlated with the abundance of macrophages and were identified as DEMRGs (Pearson correlation coefficients (PCC) > 0.6), which were mainly enriched in extracellular structure organization, lysosomal membrane, MHC protein complex binding, and so on. …”

DataSheet3_Salvia chinensia Benth induces autophagy in esophageal cancer cells via AMPK/ULK1 signaling pathway.ZIP by Lei Jia (303610)

“…<p>Salvia chinensia Benth (Shijianchuan in Chinese, SJC) has been used as a traditional anti-cancer herb. SJC showed good anti-esophageal cancer efficacy based on our clinical application. …”

Image 5_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…<p>Age-related hearing loss (ARHL) is a complex condition with genetic, aging, and environmental influences. …”

Action of disinfectant solutions on adaptive capacity and virulence factors of the Candida spp. biofilms formed on acrylic resin by Mauricio Malheiros BADARÓ (12658626)

“…The NaOCl 0.25% is the most effective and could be suitable for use as a positive control.</p></div>…”

Full dataset. by Josephine Bourner (11462776)

“…When categorising lesions according to their type, if a single lesion type was present in the image, inter-rater reliability was moderate (κ = 0.671, z = 40.6) and agreement was good (P_o = 78%), but when multiple lesion types were shown in an image, both inter-rater reliability (κ = 0.153, z = 10.5) and agreement (P_o = 29%) decreased substantially.…”

Markers for each cluster. by Xiaoke Xu (3468623)

“…This infection can lead to neurological effects and establish a viral reservoir. Given the gaps in our understanding of how these cells respond <i>in vivo</i> to acute CNS infection, we conducted single-cell RNA sequencing (scRNA-seq) on myeloid cells from the brains of three rhesus macaques 12 days after SIV infection, along with three uninfected controls. …”

Table_2_Long-term menopause exacerbates vaginal wall support injury in ovariectomized rats by regulating amino acid synthesis and glycerophospholipid metabolism.xlsx by Xia Yu (486142)

“…Purpose<p>Menopause is a risk factor for pelvic organ prolapse (POP) and is frequently associated with diminished vaginal wall support. …”

Data_Sheet_4_Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.docx by Souvarish Sarkar (8382513)

“…We validated progranulin (PGRN) as a lysosomal PD-associated protein that is downregulated by αSyn_Agg in microglia in-vivo and is expressed by microglia in post-mortem PD brain, congruent with our in vitro findings.…”

Knockdown of <i>fhplk1</i> disrupts growth and cell proliferation in juvenile <i>Fasciola hepatica in vitro.</i> by Paul McCusker (634425)

“…<p><b>(A)</b> Mean expression ±SEM of <i>fhplk1</i> (white), <i>fhh2b</i> (green) and <i>fhmlc</i> (purple) in dsRNA-treated juvenile <i>F. hepatica</i> relative to no dsRNA-treated juveniles following four weeks of repeated exposures to <i>fhplk1</i> dsRNA <i>in vitro</i> shows significant knockdown of <i>fhplk1</i> and reduction in expression of neoblast-like cell associated gene <i>fhh2b</i> relative to control dsRNA treated worms (n = 3 for each treatment, unpaired t tests). …”

Table_1_Investigation of the efficacy and safety of wild- type and triple-gene knockout pig RBC transfusions in nonhuman primates.docx by Juhye Roh (18890506)

“…Introduction<p>Decreasing rates of blood donation and close margins between blood supply and demand pose challenges in healthcare. …”

Data_Sheet_1_Biochar Amendment Alters the Nutrient-Use Strategy of Moso Bamboo Under N Additions.docx by Jinpei Gao (11011455)

“…In this study, we applied N (0, 30, 60, and 90 kg N ha⁻¹ yr⁻¹ defined as N0, N30, N60, and N90, respectively) and biochar (0, 20, and 40 t biochar ha⁻¹ defined as BC0, BC20, and BC40, respectively) to the soil of a Moso bamboo plantation. We investigated the effects of these treatments on N and phosphorus (P) resorption by young and mature bamboo plants, as well as the relationships between nutrient resorption and leaf and soil nutrient concentrations. …”

Multivariable analysis between 2006 and 2018. by Hiroaki Yoshikawa (4615801)

“…</p><p>Results</p><p>Our analysis revealed a significantly older age of onset in the 2018 cohort compared to 2006. …”

Image_10_Transcriptomic and Epigenomic Dynamics of Honey Bees in Response to Lethal Viral Infection.tif by Hongmei Li-Byarlay (5227208)

“…Israeli Acute Paralysis Virus (IAPV) is emerging as a model virus since its association with severe colony losses. …”

Transcranial direct current stimulation to enhance athletic performance outcome in experienced bodybuilders by Ali-Mohammad Kamali (4765851)

“…<div><p>Transcranial direct current stimulation (tDCS) is currently under investigation as a promising technique for enhancement of athletic performance through modulating cortical excitability. …”

Table1_Neurotrophin-4 promotes the specification of trophectoderm lineage after parthenogenetic activation and enhances porcine early embryonic development.docx by Mirae Kim (6448016)

“…<p>Neurotrophin-4 (NT-4), a neurotrophic factor, appears to affect early embryonic development because it is secreted not only by neurons but also by oviductal and uterine epithelial cells. …”

Effect of pharmacological inhibition of Cdc42-GTPase on the HTO cells. by Cristina Martin-Granados (151101)

“…<p><b>A.</b> Effect of ML141 on Cdc42 GTPase activity in unstimulated cells cultured in complete medium and in EF-stimulated HTO cells overexpressing the FLAG-NIPP1 protein variants. …”

Table_6_Transcriptomic and Epigenomic Dynamics of Honey Bees in Response to Lethal Viral Infection.XLSX by Hongmei Li-Byarlay (5227208)

“…Israeli Acute Paralysis Virus (IAPV) is emerging as a model virus since its association with severe colony losses. …”

Data_Sheet_1_Chronic alcohol-induced dysbiosis of the gut microbiota and gut metabolites impairs sperm quality in mice.ZIP by Hui Li (32376)

“…Sperm quality was significantly decreased in the alcohol-FMT group compared with the control-FMT group. …”