Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling حسب Chung, Jihyun

"…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …"
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An integrative bioinformatics pipeline to demonstrate the alteration of the interaction between the ALDH2*2 allele with NAD and Disulfiram. حسب J, Christy Priyadharshini

"…From the molecular docking analysis with NAD , we observed that the interaction affinity of the NAD decreases with the impact of E504K variant. …"
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Estimating and decomposing changes in the White–Black homeownership gap from 2005 to 2011 حسب Seah, Kiat Ying

"…Our analysis shows that the housing bust did not affect the homeownership gap uniformly. In fact, we find that the gap decreased for households that were the least likely to own and remained unchanged for households that were the most likely to own, and that Black households with around a 50% probability of homeownership were especially vulnerable to the crisis. …"
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Consumption of some food groups is associated with the risk of cardiovascular disease among Jordanians حسب Tayyem, Reema

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SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs حسب Shalaby, Raed

"…The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. …"
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Divergent changes of the elevational synchronicity in vegetation spring phenology in North China from 2001 to 2017 in connection with variations in chilling حسب Dai, Junhu

"…Specifically, SE showed a significant (p-value < .05) decreasing trend for the two southernmost mountains, indicating an increasing elevational synchronization in SOS. …"
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Estimation of Mechanical Properties of Copper Powder Filled Linear Low-Density Polyethylene Composites حسب Singh, S.

"…Conclusion: In line with the experimental data, we found that as we increased the volume fraction of the copper powder, the elongation and stress at break of the composites decreased, while the Young’s modulus increased.…"
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Quality, safety and efficiency in practice: Risk assessment and standardisation of anesthesia equipment and supplies in operating theaters of high-volume tertiary-care academic med... حسب Hammad Y.

"…Background: Operating theatres (OTs) are valuable and costly resources that need to be appropriately designed and stocked for efficient, quality and safe patient care. We assessed the logistic inefficiency including the availability and location layout of necessary supplies across OTs of a high-volume tertiary-care academic medical center. …"
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Investigating the succession process of native desert plants over hydrocarbon-contaminated soils using remote sensing techniques حسب Meshal, Abdullah

"…We also observed that the succession process of vegetation growth over hydrocarbon-contaminated soils could be associated with vegetation growth on a clean sediment layer covering the oil layer. …"
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Repositioning for pressure injury prevention in adults. حسب Gillespie, Brigid M

"…Positioning regimens: four trials compared different tilt positions We pooled data from two trials (252 participants) that compared a 30° tilt with a 90° tilt (random-effects; I² = 69%). …"
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Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update حسب Smatti, Maria K.

"…Here, we provide a review of the EBV epidemiology and the genetic variability of the oncogene LMP-1. …"
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Graph-Guided Regularized Regression of Pacific Ocean Climate Variables to Increase Predictive Skill of Southwestern U.S. Winter Precipitation حسب Tejedor, Alejandro

"…We use large ensemble simulations from a climate model to construct this regularizer, reducing the structural uncertainty in the estimation. …"
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Drastic difference between hole and electron injection through the gradient shell of Cd: XSeyZn1- xS1- y quantum dots حسب Abdellah, Mohamed

"…The observed drastic differences between the hole and electron injection are consistent with a model where the hole effective mass decreases, while the gradient shell thickness increases.…"
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Comparative Study on Gas-Sensing Properties of 2D (MoS2, WS2)/PANI Nanocomposites-Based Sensor حسب Parangusan, Hemalatha

"…The bandgap of the materials decreased due to the addition of MoS2 and WS2. We also analyzed its structural, optical and morphological properties. …"
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VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy in recurrent glioblastoma. حسب Martini, Maurizio

"…We assessed the plasma level of VEGF-121 in a brain xenograft model, in human healthy controls, and in patients suffering from recurrent GB before and after bevacizumab treatment. …"
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Na + /H + exchanger isoform 1-induced osteopontin expression facilitates cardiac hypertrophy through p90 ribosomal S6 kinase حسب Abdulrahman N.

"…Moreover, NHE1 transgenic mice also showed increased collagen deposition, upregulation of CD44 and phosphorylation of p90 ribosomal s6 kinase (RSK), effects that were regressed in OPN knockout mice. In conclusion, we developed an interesting comparative model of active NHE1 transgenic mouse lines which express a dilated hypertrophic phenotype expressing CD44 and phosphorylated RSK, effects which were regressed in absence of OPN.…"
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Privacy-preserving federated learning cyber-threat detection for intelligent transport systems with blockchain-based security حسب Moulahi, Tarek

"…Subsequently, by using blockchain and by applying an aggregation strategy to different models, models from the previous step were uploaded in a smart contract. Lastly, we returned the updated models to the vehicles. …"
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Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice حسب Ayman, Alzu'bi

"…These findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (BDNF), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. …"
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Thermal and mechanical stability of microwave sintered cold compact bismuth telluride thermoelectric material حسب Farheen F., Jaldurgam

"…The TGA-DSC results indicate a slight mass gain at 350 °C followed by a steep weight loss beyond 550 °C suggesting good thermal stability when the experimental temperature is below 350 °C. …"
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PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells حسب Banasavadi-Siddegowda, Y K

"…Our results uncover a very significant role for PRMT5 in GBMNS self-renewal capacity and proliferation. …"
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