Ubiquitin-Related Modifier 1 (URM-1) Modulates Cx43 in Breast Cancer Cell Lines. by El-Hajjar, Layal

“…In particular, the PTM of connexin 43 (Cx43), a tumor suppressor protein, regulates its turnover and activity. …”
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Fluorinated Benzofuran and Dihydrobenzofuran as Anti-Inflammatory and Potential Anticancer Agents by Ayoub, Abeer J.

“…Targeting inflammation in cancer associated with chronic inflammation is a promising therapy. In the present study, we investigated the anti-inflammatory effects of fluorinated benzofuran and dihydrobenzofuran derivatives in macrophages and in the air pouch model of inflammation, as well as their anticancer effects in the human colorectal adenocarcinoma cell line HCT116. …”
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Dynamic workload patterns prediction for proactive auto-scaling of web applications by Iqbal W.

“…This may lead to inappropriate resource provisioning decisions. In this paper, we address these challenges by proposing a framework for prediction of dynamic workload patterns as follows. …”
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Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice by Ayman, Alzu'bi

“…These findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (BDNF), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. Additionally, we showed that AB-FUBINACA significantly decreased the expression of NR1, an important functional subunit of glutamate/NMDA receptors and closely implicated in the development of toxic psychosis. …”
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Profiling of the Differentially Expressed Genes of Inflammation and Angiogenesis of Human Brain Microvascular Endothelial Cells Evoked by Cell Injury In-Vitro to Mimic Acute Ischem... by Al Hamed, Fatima Alzahra Mahmoud

“…Acute IS (AIS) injury of PHBMEC is not well characterized in terms of its consequences on cell functions using genomic function profiling. In our study, we aimed to establish a new model of an acute in-vitro ischemic stroke, within a time limit of 2 hrs., with depriving whole nutrients and not just glucose, under hypoxic condition, in a model we created as oxygen nutrients deprivation (OND). …”
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Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria by Al-Sadeq, Duaa W.

“…In this study, we present the clinical and biochemical characterization of two novel CBS missense mutations that do not respond to pyridoxine treatment, namely c.689T > A (L230Q) and 215A > T (K72I), identified in a Chinese patient. …”
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Effect of biochars produced from solid organic municipal waste on soil quality parameters by Randolph, P.

“…Select municipal organic wastes (newspaper, cardboard, woodchips and landscaping residues) individually or in a 25% blend of all four waste streams were used as feedstocks of biochars. …”
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DIFFERENTIAL EXPRESSION OF MICRORNAS BY ANTI-OBESITY TREATMENT SULFORAPHANE IN SKELETAL MUSCLE OF DIET-INDUCED OBESITY IN MICE by ALASMAR, DIMA RIYAD

“…Furthermore, we identified eight differentially expressed miRNAs in SFN-treated DIO mice, of which five were upregulated (mmu-miR-150-5p, mmu-miR-486a-3p, mmu-miR-126b-5p, mmu-miR-140-3p, mmu-miR-92a-3p) and three were downregulated (mmu-miR-101a-3p, mmu-miR-29c-3p, mmu-miR-3074-5p). …”
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Screening the growth inhibition mechanism of sulfate reducing bacteria by chitosan/lignosulfonate nanocomposite (CS@LS) in seawater media by Kashif, Rasool

“…Herein, we have developed a biodegradable chitosan/lignosulfonate nanocomposite (CS@LS) as an efficient green biocide for the inhibition of SRBs biofilms. …”
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How to govern the non-cooperative amateur drones? by He D.

“…However, non-cooperative UAVs may cause abuses of low-altitude airspace with potential security and safety problems, posing increasing challenges for low-altitude airspace management. In this article, we analyze the mechanisms to counter UAVs. Then GNSS spoofing on a UAV is described and our experimental results are reported. …”
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Scalable Containerized Pipeline for Real-time Big Data Analytics by Aurangzaib, Rana

“…The traditional data-stream processing systems are inefficient in processing big data for detecting anomalies, classifications, clustering, and prediction in real-time using minimal resources. In this paper, we address this limitation by proposing a scalable pipeline for real-time processing of big data streams. …”
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Thermally assisted efficient electrochemical lithium extraction from simulated seawater by Yanxi, Yu

“…Based on these understandings, we demonstrated that a thermally assisted electrochemical lithium extraction process could achieve rapid (36.8 mg g-1 day-1) and selective (51.79% purity) lithium extraction from simulated seawater with an ultrahigh Na+/Li+ molar ratio of 20,000. …”
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Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor. by Padmanabhan, Regina

“…Precisely, several questions regarding the right combination of drugs, drug modality, and effective dose recommendations pertaining to the use of ICB-based therapy for HER2+ patients remain unanswered. In this study, we use a mathematical modeling-based approach to quantify the growth inhibition of HER2+ breast cancer (BC) cell colonies (ZR75) when treated with anti-HER2; trastuzumab (TZ) and anti-PD-1/PD-L1 (BMS-202) agents. …”
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Burden and trend of diet-related non-communicable diseases in Australia and comparison with 34 OECD countries, 1990-2015: findings from the Global Burden of Disease Study 2015. by Melaku, Yohannes Adama

“…Diet is a major determining factor for many non-communicable chronic diseases (NCDs). …”
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Kv7 Channel Activators Flupirtine and ML213 Alleviate Neuropathic Pain Behavior in the Streptozotocin Rat Model of Diabetic Neuropathy by Ahmed, Ashraf Ibrahim

“…Background & Objective: Chronic peripheral neuropathic pain (PNP) is a debilitating condition that is associated with many types of injury/diseases, including diabetes mellitus. …”
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Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging mice by Cugno, Chiara

“…Rosiglitazone is an effective insulin-sensitizer, however, associated with bone loss mainly due to increased bone resorption, and bone marrow adiposity, and decreased bone formation. We investigated the effect of the co-administration of fish oil (FO) rich in omega-3 fatty acids (FAs) on rosiglitazone (RSG)-induced bone loss in aging C57BL/6 mice and the mechanisms underlying potential preventive effect. …”
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Role of Graphene Oxide in Bacterial Cellulose−Gelatin Hydrogels for Wound Dressing Applications by Khan, Muhammad Umar Aslam

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Conceptual Based Hidden Data Analytics and Reduction Method for System Interface Enhancement Through Handheld devices by Babi, Syrinne Adnan

“…In addition, by using online consecutive reductions on search results, we adopted a method of displaying results in order of decreasing relevance. …”
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Who needs RDD? Combining directory listings with cell phone exchanges for an alternative telephone sampling frame by Guterbock, Thomas

“…The portion of the telephone universe that is excluded in the EWP+cell design is getting smaller all the time, therefore its bias relative to the RDD+cell design is decreasing over time. Overall, the EWP+cell design seems to be a useful alternative.…”
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Kappa-Distributed Electrons in Solar Outflows: Beam-Plasma Instabilities and Radio Emissions by Lazar, M.

“…Electrostatic (ES) wave instabilities are assumed to be at the origin of radio emissions from interplanetary shocks, and solar coronal sources are most likely induced by electron beams, more energetic but less dense than electron strahls in the solar wind. In this paper, we present the results of a new dispersion and stability analysis for electron populations with Kappa velocity distributions, as often indicated by in situ observations. …”
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