Pharmacokinetics and pharmacodynamics after treatment of DIO-mice with HI, X10 and IGF-1 by sc injection. by Henning Hvid (486358)

“…<p>A: Plasma concentrations measured in mice treated with HI, X10 or IGF-1. …”

Plant Food Delphinidin-3-Glucoside Significantly Inhibits Platelet Activation and Thrombosis: Novel Protective Roles against Cardiovascular Diseases by Yan Yang (33204)

“…Dp-3-g also significantly inhibited thrombus growth in a carotid artery thrombosis model. To elucidate the mechanisms, we examined platelet activation markers via flow cytometry and found that Dp-3-g significantly inhibited the expression of P-selectin, CD63, CD40L, which reflect platelet α- and δ-granule release, and cytosol protein secretion, respectively. …”

Functional Loss of Two Ceramide Synthases Elicits Autophagy-Dependent Lifespan Extension in <i>C. elegans</i> by Mai-Britt Mosbech (435186)

“…<div><p>Ceramide and its metabolites constitute a diverse group of lipids, which play important roles as structural entities of biological membranes as well as regulators of cellular growth, differentiation, and development. …”

Data_Sheet_7_Effects of Cultured Root and Soil Microbial Communities on the Disease of Nicotiana tabacum Caused by Phytophthora nicotianae.pdf by Tianbo Liu (1390855)

“…In the field experiment, the root functional microflora (RFM) showed a greater suppressiveness of black shank than the soil functional microflora (SFM), while both RFM and SFM altered diversity, composition, structure, and interaction of soil bacterial communities during plant growth. …”

Data_Sheet_1_Peroxisome Proliferator-Activated Receptor α Activation Protects Retinal Ganglion Cells in Ischemia-Reperfusion Retinas.docx by Fei Yao (43685)

“…However, the mechanism related to retinal IR is controversial, and a drug that could prevent the RGC loss caused by IR is still lacking. …”

Image_2_Response of bacterial communities (Marivita, Marinobacter, and Oceanicaulis) in the phycosphere to the growth of Phaeodactylum tricornutum in different inorganic nitrogen s... by Xiaoxue Wei (14672540)

“…Our results explain when and how the phycosphere bacterial communities responded to algal biomass variations. The study provides a foundation for the quantitative relationship among nutrients, microalgae, and bacteria in this system.…”

DataSheet_1_Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstiti... by Eleanor Valenzi (8508294)

“…Alveolar type I cells were dramatically decreased in both IPF and SSc-ILD, with a distinct transcriptome signature separating these cells by disease. …”

Image3_Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice.TIF by Lu Xia (1509745)

“…</p><p>Conclusion: GSDMD-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures. Our study provides a new potential therapeutic target for seizure control.…”

Table_1_Integrative Analysis Toward Different Glucose Tolerance-Related Gut Microbiota and Diet.DOCX by Rebiya Nuli (6740093)

“…Unbalanced nutrient intake in the three groups may affect the structure and abundance of the gut microbiota, which may play a role in the occurrence and development of T2DM.…”

DataSheet1_Improved diagnosis of inflammatory bowel disease and prediction and monitoring of response to anti-TNF alpha treatment based on measurement of signal transduction pathwa... by Wilbert Bouwman (9534287)

“…Differential diagnosis remains a challenge. Anti-TNFα treatment is an important treatment for IBD, yet resistance frequently occurs and cannot be predicted. …”

DataSheet_1_Humoral, Cellular and Cytokine Immune Responses Against SARS-CoV-2 Variants in COVID-19 Convalescent and Confirmed Patients With Different Disease Severities.docx by Chun-Hsiang Chiu (4093444)

“…Furthermore, there was a significant correlation among disease severity, humoral immune response, and specific cytokines/chemokine levels. …”

Table_9_Characterization of the gene expression profile response to drought stress in Haloxylon using PacBio single-molecule real-time and Illumina sequencing.XLSX by Fang Yang (123514)

“…Thisis the first full-length transcriptome report concerning the responses of H. ammodendron and H. persicum to drought stress. The results provide a foundation for further study of the adaptation to drought stress. …”

High Fat Diet Subverts Hepatocellular Iron Uptake Determining Dysmetabolic Iron Overload by Paola Dongiovanni (300534)

“…Aims of this study were to assess the effect a high-fat diet (HFD) on hepatic iron metabolism in an experimental model in rats, to further characterize the effect of free fatty acids on iron metabolism in HepG2 hepatocytes <i>in vitro</i>, and to assess the translational relevance in patients with fatty liver with and without iron accumulation. …”

Table1_Geochemistry of Formation Water and Its Implications for Petroleum Source Rocks in the Fengcheng Formation, Mahu Depression, Xinjiang, China.xlsx by Jian Wang (5901)

“…From the first member to the third member of the formation, the salinity first increases and then decreases. This low-high-low trend corresponds to the initial stage of alkaline lake development followed by strong alkali formation and a final stage of water retreat. …”

Table3_Assessment of CircRNA Expression Profiles and Potential Functions in Brown Adipogenesis.XLSX by Pengpeng Zhang (583380)

“…<p>Brown adipose tissue (BAT) is specialized for energy expenditure, thus a better understanding of the regulators influencing BAT development could provide novel strategies to defense obesity. …”

Natalizumab treatment blocks the traffic and accumulation of SIV infected monocyte/macrophages in the brain. by Jennifer H. Campbell (353635)

“…<p>(A) Natalizumab treatment on 28 dpi (late), resulted in scattered SIV p28⁺ and RNA⁺ cells in the CNS (frontal cortex, parietal cortex, occipital cortex, brainstem) relative to controls, all sacrificed with progression to AIDS. …”

Severe obesity and the impact of medical weight loss on estimated glomerular filtration rate by Amy E Rothberg (8383968)

“…In subjects with severe obesity undergoing medical weight loss, estimating equations that use cystatin C and are indexed to actual BSA may provide a more accurate assessment of renal function.</p><p></p>…”

Image_6_Abnormal Glucose Metabolism in Male Mice Offspring Conceived by in vitro Fertilization and Frozen-Thawed Embryo Transfer.PDF by Ningxin Qin (10115329)

“…It is of great necessity to assess the safety of FET and investigate the long-term effect including glucose metabolism on FET-conceived offspring. The mouse model is a highly efficient method to figure out the relationship between the process of FET and offspring health. …”

DataSheet3_Sanqi Oral Solution Mitigates Proteinuria in Rat Passive Heymann Nephritis and Blocks Podocyte Apoptosis via Nrf2/HO-1 Pathway.zip by Xiaowan Wang (9704207)

“…To investigate the effects of SQ, we established the experimental passive Heymann nephritis (PHN) rat model induced by anti-Fx1A antiserum in vivo and doxorubicin hydrochloride (ADR)-injured apoptotic podocyte model in vitro. …”

Image_4_Splenic SUMO1 controls systemic inflammation in experimental sepsis.jpeg by Ayman Youssef (16537653)

“…In the spleen, endotoxemia induced a distinct temporal and substrate specificity for SUMO1 and SUMO2/3, and both were inhibited by TAK981. …”