Pharmacological Targeting of Native CatSper Channels Reveals a Required Role in Maintenance of Sperm Hyperactivation by Anne E. Carlson (242598)

“…HC-056456 does not prevent activation of motility by HCO₃⁻ but does prevent the development of hyperactivated motility by capacitating incubations, thus producing a phenocopy of the CatSper-null sperm. When applied to hyperactivated sperm, HC-056456 causes a rapid, reversible loss of flagellar waveform asymmetry, similar to the loss that occurs when Ca²⁺ entry through the CatSper channel is terminated by removal of external Ca²⁺. …”

Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model by Soeren Erik Pischke (6889778)

“…<div><p>Introduction</p><p>Right ventricular (RV) myocardial dysfunction is a common feature in septic shock. It can worsen outcome, but the etiology is poorly understood. …”

Systematic analysis of <i>CDC73</i> as a suppressor of GCRs selected in the dGCR assay. by Rahul V. Nene (4752033)

“…Single mutations causing decreased telomere lengths are underlined [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007170#pgen.1007170.ref046" target="_blank">46</a>,<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007170#pgen.1007170.ref047" target="_blank">47</a>]. …”

Image_2_A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol.tif by Jinglei Xiao (1422004)

“…Mathematical simulation indicated that a left shift of Na_V activation produced a Hopf bifurcation, leading to cell oscillations. …”

Image_3_The IAG-Switch and Further Transcriptomic Insights Into Sexual Differentiation of a Protandric Shrimp.TIF by Tom Levy (4708123)

“…<p>The insulin-like androgenic gland hormone (IAG) secreted from the androgenic gland (AG) is a unique endocrine controller (the IAG-switch) of crustacean sexual differentiation. …”

Image_2_Measuring the inequalities in healthcare resource in facility and workforce: A longitudinal study in China.JPEG by Enhong Dong (10812742)

“…Objective<p>The study aimed to measure time trends of inequalities of the geographical distribution of health facilities and workforce in Shanghai from 2010 to 2016 and used a spatial autocorrelation analysis method to precisely detect the priority areas for optimizing health resource reallocation in metropolises like Shanghai in developing countries.…”

Image_3_Measuring the inequalities in healthcare resource in facility and workforce: A longitudinal study in China.JPEG by Enhong Dong (10812742)

“…Objective<p>The study aimed to measure time trends of inequalities of the geographical distribution of health facilities and workforce in Shanghai from 2010 to 2016 and used a spatial autocorrelation analysis method to precisely detect the priority areas for optimizing health resource reallocation in metropolises like Shanghai in developing countries.…”

Table_3_Prediction of Soil Formation as a Function of Age Using the Percolation Theory Approach.XLSX by Markus Egli (3666178)

“…Nonetheless, the model is able to generate soil depth and confirms decreasing production rates with age. A steady state for soils is not reached before about 100 kyr to 1 Myr</p>…”

Does dexmedetomidine have an antiarrhythmic effect on cardiac patients? A meta-analysis of randomized controlled trials by Xiaoyan Ling (4903786)

“…Dexmedetomidine (DEX) is a popular medicine used for sedation in the ICU, and its other pharmacological characteristics are gradually being uncovered.…”

Data_Sheet_1_Hopium or empowering hope? A meta-analysis of hope and climate engagement.docx by Nathaniel Geiger (4007264)

“…<p>Researchers are increasingly examining whether hope can motivate action on climate change, or conversely, whether it might demotivate such action. We present a meta-analysis (k = 46) of quantitative studies examining the relationships between measures and manipulations of hope with climate engagement. …”

RhoB Acts as a Tumor Suppressor That Inhibits Malignancy of Clear Cell Renal Cell Carcinoma by Weihao Chen (431221)

“…These findings show that RhoB may play a tumor suppressive role in ccRCC cells, raising its potential value in futural therapeutic target for the patients of ccRCC.…”

Natural Form of Noncytolytic Flexible Human Fc as a Long-Acting Carrier of Agonistic Ligand, Erythropoietin by Se Jin Im (204954)

“…<div><p>Human IgG1 Fc has been widely used as a bioconjugate, but exhibits shortcomings, such as antibody- and complement-mediated cytotoxicity as well as decreased bioactivity, when applied to agonistic proteins. …”

Table_2_Prediction of Soil Formation as a Function of Age Using the Percolation Theory Approach.XLSX by Markus Egli (3666178)

“…Nonetheless, the model is able to generate soil depth and confirms decreasing production rates with age. A steady state for soils is not reached before about 100 kyr to 1 Myr</p>…”

Data_Sheet_1_Extracutaneous features and complications of the Ehlers-Danlos syndromes: A systematic review.docx by Brent J. Doolan (14490089)

“…Introduction<p>The Ehlers-Danlos syndromes (EDS) comprise a group of inherited connective tissue disorders presenting with variable fragility to skin, soft tissue, and certain internal organs, which can cause significant complications, particularly arterial rupture, bowel perforation and joint difficulties. …”

Table1_BTBD10 is a Prognostic Biomarker Correlated With Immune Infiltration in Hepatocellular Carcinoma.DOCX by Jianhui Li (361790)

“…<p>Background: BTBD10 serves as an activator of Akt family members through decreasing the protein phosphatase 2A-mediated dephosphorylation. …”

OVA66, a Tumor Associated Protein, Induces Oncogenic Transformation of NIH3T3 Cells by Wei Rao (535824)

“…Analysis of PI3K/AKT and ERK1/2 MAPK signaling pathways by serum stimulation indicated hyperactivation of AKT and ERK1/2 in NIH3T3-flagOVA66 cells compared with NIH3T3-mock cells, while a decreased level of p-AKT and p-ERK1/2 were observed in OVA66 knocked down HeLa cells. …”

Table_1_The IAG-Switch and Further Transcriptomic Insights Into Sexual Differentiation of a Protandric Shrimp.xlsx by Tom Levy (4708123)

“…<p>The insulin-like androgenic gland hormone (IAG) secreted from the androgenic gland (AG) is a unique endocrine controller (the IAG-switch) of crustacean sexual differentiation. …”

Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy by Hui Xiao (185054)

“…<div><p>Interleukins-6 (IL-6)/GP130 signaling pathway represents a promising target for cancer therapy due to its critical role in survival and progression of multiple types of cancer. …”

A Comprehensive Study of Extended Tetrathiafulvalene Cruciform Molecules for Molecular Electronics: Synthesis and Electrical Transport Measurements by Christian R. Parker (1714033)

“…The molecules were subjected to a comprehensive study of their conducting properties as well as their photophysical and electrochemical properties in solution. …”

Image_2_Schlafen family is a prognostic biomarker and corresponds with immune infiltration in gastric cancer.tif by Jiannan Xu (12282551)

“…We isolated three samples of peripheral blood mononuclear cell (PBMC) and activated T cells; the results showed the expression of SLFN family members decreased significantly when T cell active. In conclusion, the SLFN family of proteins may act as a prognostic indicator of GC and is associated with immune cell infiltration and immune checkpoint expression in GC. …”