Increased total cell counts and pro-inflammatory cytokines in BAL fluid from SP-A -/- mice. by Anastasia K. Ketko (491544)

“…IL-1β was decreased in the lung of SP-A-/- mice 6 hours following PAK infection and no difference was observed in IL-1β between SP-A-/- and SP-A+/+ mice following <i>fliC</i> infection (B). …”

Recombinant IL-4 suppressed the stimulatory effect of PGI₂ analogs on IL-17A expression. by Weisong Zhou (165396)

“…<p>CD11c⁺ cell-containing CD4⁺CD62L⁺ cells isolated from spleens of OT II mice were activated with OVA_323–339 (1 µg/ml) and anti-CD28 (1 µg/ml) in the presence of IL-23 (10 ng/ml) and treated with iloprost, cicaprost, or respective vehicles for 4 days. (A and B) Iloprost and cicaprost decreased IL-4 production, but not IFN-γ production as determined by ELISA. …”

Effect of MDMA and HT on the a-wave and b-wave at 3 h and 24 h. by João Martins (5652628)

“…(A₂, B₂) Both MDMA and HT groups presented decreased time to peak values at 3 h time point when compared to Baseline ERG in both the a-wave and b-wave, while no significant differences were found at 24 h time point compared to Baseline ERG in all groups. *** p<0.001 MDMA group compared to Baseline ERG; ++ p<0.01, +++ p<0.001 HT group compared to Baseline ERG. …”

Hemoglobin A1c Levels and Risk of Severe Hypoglycemia in Children and Young Adults with Type 1 Diabetes from Germany and Austria: A Trend Analysis in a Cohort of 37,539 Patients be... by Beate Karges (640991)

“…From 1995 to 2012, the relative risk (RR) for severe hypoglycemia and coma per 1% HbA1c decrease declined from 1.28 (95% CI 1.19–1.37) to 1.05 (1.00–1.09) and from 1.39 (1.23–1.56) to 1.01 (0.93–1.10), respectively, corresponding to a risk reduction of 1.2% (95% CI 0.6–1.7, <i>p</i><0.001) and 1.9% (0.8–2.9, <i>p</i><0.001) each year, respectively. …”

Human A53T α-Synuclein Causes Reversible Deficits in Mitochondrial Function and Dynamics in Primary Mouse Cortical Neurons by Li Li (14993)

“…Furthermore, we found that rapamycin, an autophagy inducer, rescued the decreased mitochondrial mobility. Taken together, these data demonstrate that A53T α-syn impairs mitochondrial function and dynamics and the deficit of mitochondrial transport is reversible, providing further understanding of the disease pathogenesis and a potential therapeutic strategy for PD.…”

Knockdown of transcription factors, SP1 and EGR1, attenuates miR-27a expression. by Bum-Yong Kang (350760)

“…HPAEC mRNA or proteins were then isolated. qRT-PCR was performed demonstrating decreases in SP1 (<b>A</b>) or EGR1 (<b>C</b>) mRNA levels following treatment with siRNA. …”

Efficient assembly of CENP-A at centromeres requires SMC2. by Alexander Samoshkin (260480)

“…<p>A) CENP-A levels are not significantly decreased in condensin-depleted cells. …”

Vitamin A supplementation reduces the Th17-Treg – Related cytokines in obese and non-obese women by Mahdieh Abbasalizad Farhangi (7513307)

“…The mean concentrations of IL-17 and TGF-β were significantly decreased after vitamin A supplementation in non-obese and obese women respectively. …”

<i>In vivo</i> dynamic near-infrared fluorescent imaging of A-431 tumor models. by Lingbo Zhang (132359)

“…<p>A: The representative fluorescence images of the tumor regions in mice were acquired at 4 h post injection of EGF-Cy5.5. …”

Estimation of A3G and Vif production rates. by Iraj Hosseini (184245)

“…<p>(A) shows the optimum <i>P_A3G</i> for the ΔVif case (<i>P_Vif</i> = 0), whereas (B) shows the fitness error heat-map for a wide range of values of (<i>P_Vif</i>, <i>P_A3G</i>) for the WT case. …”

Illustration of controller breakdown of the scheme in Fig 2 when inflows to <i>A</i> exceed the outflows from <i>A</i>. by Peter Ruoff (248735)

“…Vertical arrows show the times the <i>k</i>₁ steps are increased. Also note the decrease in the oscillator’s frequency when <i>k</i>₁ gets larger. …”

Let-7a Is a Direct EWS-FLI-1 Target Implicated in Ewing's Sarcoma Development by Claudio De Vito (210326)

“…Consistent with these observations, systemic delivery of synthetic let-7a into ESFT-bearing mice restored its expression in tumor cells, decreased <em>HMGA2</em> expression levels and resulted in ESFT growth inhibition in vivo. …”

Regulation of USP2a and MDM2 in response to <i>as-</i>APF. (A by Jayoung Kim (153487)

“…Western blot with anti-USP2a antibody showed that the level of USP2a level was stably decreased in response to <i>as</i>-APF treatment, but this was only transiently reduced by control mock APF peptide. …”

Ublituximab in relapsing forms of multiple sclerosis: a profile of its use by Hannah A. Blair (13864794)

“…</p> <p><strong>Authorship and conflict of interest</strong> Hannah A. Blair is a salaried employee of Adis International Ltd/Springer Nature and declares no relevant conflicts of interest. …”

Junction assembly in 3D cell cultures is severely impaired for W2A mutant. by Stefanie Bunse (491659)

“…Both R14E and V81D/V174D needed twice the Ca²⁺-concentration (0.8 mM) to show a significant increase in roundness emphasizing that in 3D, loss of either X-dimer or the <i>cis</i> interface leads to a decreased Ca²⁺-sensitivity in junction assembly (n for each condition ≥ 4, Mann-Whitney U test, p < 0.05). …”

Highly purified fetuin-A inhibited HMGB1 release <i>in vivo</i> and <i>in vitro</i>. by Wei Li (7081)

“…<i>Administration of fetuin-A decreased circulating HMGB1 levels in endotoxemia and sepsis.…”

Attenuation of bleomycin-induced lung fibrosis upon anti-IL-17A treatment. by Paméla Gasse (209357)

“…Active MMP-2 upregulated upon BLM in the BALF of wild-type mice was greatly reduced after 6 treatments with neutralizing antibody against IL-17A (A). TIMP-1 in lung was also significantly decreased after treatment with neutralizing antibody against IL-17A in comparison to untreated BLM mice (B). …”

Supplementary Material for: CD300a Regulates Mouse Macrophage Functionality in Allergic Inflammation by Puzzovio P.G. (14800660)

“…On the other hand, CD300a absence did not affect phagocytosis. WT MΦ incubated with supernatants of non-activated and IgE-activated BMMCs presented with increased iNOS expression and decreased Arg1 levels. …”

Elevated Level of Wnt5a Protein in Localized Prostate Cancer Tissue Is Associated with Better Outcome by Azharuddin Sajid Syed Khaja (199670)

“…In vitro, we demonstrated that recombinant Wnt5a decreased invasion of 22Rv1 and DU145 cells and that siRNA knockdown of endogenous Wnt5a protein led to increased invasion of 22Rv1 and LNCaP cells.…”

Light-Controlled Anticancer Activity and Cellular Uptake of a Photoswitchable Cisplatin Analogue by Marta Stolarek (14480838)

“…The <i>trans</i> photoisomer was bound stronger by bovine serum albumin and induced a greater decrease in cellular glutathione levels than the <i>cis</i> photoisomer.…”