Matrix is a critical determinant of DNMT3A expression in visceral smooth muscle cells. by Jia-Xin Jiang (442775)

“…<p>SMC were plated on native (NC) or denatured collagen (DNC) at low density (4×10⁴ cells/mL) for 6 hours in EMEM with 6% FCS, then media was changed to 2% FCS in EMEM. (A) DNMT3A expression increases in the nucleus in response to denatured matrix, while α-smooth muscle actin (α-SMA) expression decreased. …”

Novel model for the manipulation of host responses by <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> (MAP) for its survival during subclinical stages of Johne’s disease.... by Hyun-Eui Park (4047733)

“…Upregulation of PIP5K1C and downregulation of IL-17A, IL-17F, and IL-26 induces a loss of granuloma integrity, which can result in fecal shedding and dissemination of MAP. …”

<i>MptriA</i>, an Acetyltransferase Gene Involved in Pigment Biosynthesis in <i>M. purpureus</i> YY‑1 by Bin Liang (228729)

“…The Δ<i>MptriA</i> strain showed decreased pigment and citrinin production during the liquid-fermentation process. …”

Placental Proteomics Provides Insights into Pathophysiology of Pre-Eclampsia and Predicts Possible Markers in Plasma by Sheon Mary (3696952)

“…Some of the differentially expressed proteins were monitored in the plasma by multiple reaction monitoring analysis, which showed an increase in apolipoproteins A-I and A-II in gestational weeks 26–30 (2-fold, <i>p</i> < 0.01), while haptoglobin and hemopexin decreased in gestational weeks 26–30 and week 40/at delivery (1.8 fold, <i>p</i> < 0.01) in pre-eclamptic patients. …”

Placental Proteomics Provides Insights into Pathophysiology of Pre-Eclampsia and Predicts Possible Markers in Plasma by Sheon Mary (3696952)

“…Some of the differentially expressed proteins were monitored in the plasma by multiple reaction monitoring analysis, which showed an increase in apolipoproteins A-I and A-II in gestational weeks 26–30 (2-fold, <i>p</i> < 0.01), while haptoglobin and hemopexin decreased in gestational weeks 26–30 and week 40/at delivery (1.8 fold, <i>p</i> < 0.01) in pre-eclamptic patients. …”

Placental Proteomics Provides Insights into Pathophysiology of Pre-Eclampsia and Predicts Possible Markers in Plasma by Sheon Mary (3696952)

“…Some of the differentially expressed proteins were monitored in the plasma by multiple reaction monitoring analysis, which showed an increase in apolipoproteins A-I and A-II in gestational weeks 26–30 (2-fold, <i>p</i> < 0.01), while haptoglobin and hemopexin decreased in gestational weeks 26–30 and week 40/at delivery (1.8 fold, <i>p</i> < 0.01) in pre-eclamptic patients. …”

Transporter inhibitor MK571 inhibited the generation and excretion of demethoxycurcumin-<i>O</i>-glucuronides in HeLa1A1 cells. by Beibei Zhang (509356)

“…<p>(A) MK571 (5 and 20 μM) inhibited the excretion of demethoxycurcumin-<i>O</i>-glucuronides (G1) in extracellular medium; (B) Inhibitory effects of MK571 (5 and 20 μM) on the excretion of demethoxycurcumin-<i>O</i>-glucuronides (G2) in extracellular solution; (C) MK571 (5 and 20 μM) decreased the efflux excretion rates of G1 and G2; (D) MK571 (5 and 20 μM) evaluated the intracellular levels of G1 and G2; (E) MK571 (5 and 20 μM) reduced the overall formation (<i>f</i>_met) of G1 and G2 in HeLa1A1 cell; The concentration of demethoxycurcumin was 4 μM. …”

Example of a raw sEMG signal of the gastrocnemius muscle. by I. Moll (14227650)

Dissection of the regulatory role for the N-terminal domain in <i>Candida albicans</i> protein phosphatase Z1 by Krisztina Szabó (3860470)

“…The deletion of the N-terminal 1–16 amino acids and the G2A mutation significantly decreased the specific activity of the enzyme. …”

Presentation_1_Transitional B Cells and TLR9 Responses Are Defective in Selective IgA Deficiency.PDF by Andri L. Lemarquis (5148806)

“…Finally, CpG stimulation failed to induce IgA production in IgAD individuals. Collectively, our results demonstrate a defect of the TLR9 responses in IgAD that leads to B cell dysregulation and decreased IgA production.…”

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation by Lina Zhou (473857)

“…The lower fatty acyl pool may be mediated by the lower protein expression levels of long-chain acyl-CoA synthetase 1 (ACSL1), ACSL4, and very long-chain acyl-CoA synthetase 3 (ACSVL3) in <i>IDH1</i> mutant glioma. …”

DataSheet_1_Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris.docx by Daniela Kugelmann (625708)

“…In primary human keratinocytes, inhibition of ADAM10, but not ADAM17, reduced loss of cell adhesion and fragmentation of Dsg1 and Dsg3 immunostaining in response to a PV1-IgG from a mucocutaneous PV patient. Similarly, inhibition of ADAM10 in dissociation assay decreased fragmentation of primary keratinocytes induced by a monoclonal antibody against Dsg3 and by PV-IgG from two other patients both suffering from mucosal PV. …”

The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases by Claudia Pérez (351604)

“…Increased <i>Pdrg1</i> expression is detected in acute liver injury and hepatoma cells, together with decreased <i>Mat1a</i> expression and nuclear accumulation of MATα1. …”

Video_1_Mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke.MP4 by Shuting Zhang (436486)

“…</p>Results<p>After 12 days of intervention, the IL-17A, TNF-α, and NIHSS levels were significantly decreased, while the VEGF-A, MMSE, FMA, and MBI levels were significantly increased in both disease groups. …”

Data_Sheet_1_Characterization of Enterovirus Associated m6A RNA Methylation in Children With Neurological Symptoms: A Prospective Cohort Study.docx by Danping Zhu (6758192)

“…The different m6A RNA methylation was increased in the transcriptome’s CDS regions but decreased in both the 3′UTRs and stop codon among the NS group. …”

Surface Immobilization of Human Arginase-1 with an Engineered Ice Nucleation Protein Display System in <i>E</i>. <i>coli</i> by Zhen Zhang (86004)

“…<div><p>Ice nucleation protein (INP) is frequently used as a surface anchor for protein display in gram-negative bacteria. …”

Reduction in skeletal muscle fibrosis of spontaneously hypertensive rats after laceration by microRNA targeting angiotensin II receptor by Roberta Sessa Stilhano (328847)

“…The <i>tibialis anterior</i> (TA) muscle of spontaneously hypertensive (SHR) and Wistar rats (WR) were lacerated and a lentivector encoding a microRNA targeting AngII receptor type 1 (<i>At1</i>) (Lv-mirAT1a) or control (Lv-mirCTL) was injected. …”

A Fractional Bond Order of 1/2 in Pd₂⁵⁺−Formamidinate Species; The Value of Very High-Field EPR Spectra by John F. Berry (1391989)

“…Upon oxidation of the precursor, the Pd−Pd distance decreases by 0.052 Å from 2.6486(8) to 2.597(1) Å. …”

Sociodemographic correlates of HIV drug resistance and access to drug resistance testing in British Columbia, Canada by Genevieve Rocheleau (4455214)

“…A higher median income (aOR: 0.83, 0.77–0.89) and higher percentage of those with aboriginal ancestry (aOR: 0.85, 0.76–0.95) were census tract-level sociodemographic covariates associated with decreased access to DRT. …”

Adipogenic differentiation of hVSCs from VAT and SAT of subjects with different BMI and HOMA-IR index. by Adriana-Mariel Gentile (835446)

“…<p>A) Representative photomicrographs of undifferentiated VAT-derived stromal cells (VAT-VSCs) and SAT-derived stromal cells (SAT-VSCs) (left column) and differentiated adipocytes from VAT-VSCs (upper row) and SAT-VSCs (lower row) stained with the lipophilic marker oil red O. …”