Table_3_HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages.xlsx by Mohammed Ghiboub (9463586)

“…Cytokine and gene expression analyses confirmed that IFNγ-treated macrophages consistently develop a cytokine response after LPS repeated challenge, but pretreatment with HDAC3i or HDAC3 siRNA reinstates a state of tolerance reflected by general suppression of tolerizable genes, possibly through decreasing TLRs expression, and particularly TLR4/CD14. …”

DataSheet_2_HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages.pdf by Mohammed Ghiboub (9463586)

“…Cytokine and gene expression analyses confirmed that IFNγ-treated macrophages consistently develop a cytokine response after LPS repeated challenge, but pretreatment with HDAC3i or HDAC3 siRNA reinstates a state of tolerance reflected by general suppression of tolerizable genes, possibly through decreasing TLRs expression, and particularly TLR4/CD14. …”

The polarization phase of DH82 is directed into M2 phase when treated with EVs. by Su-Min Park (11185660)

“…<p><b>(a, b)</b> The mRNA level of IL-1b and IL-6, which is the marker of M1 macrophage phase, was decreased in EV treated groups and significantly decreased in EV^DFO treated group compared to EV^non treated group. …”

Predicted disease and biological functions associated with cellular gene expression. by For Yue Tso (178484)

“…Given that ADIPOQ is represented by a blue circle (down-regulated genes in lesions), it means that the downregulation of ADIPOQ in lesion results in activation of glucose metabolism disorder. …”

NGF accelerates nuclear trafficking of FGFR1 by reducing FGFR1 nuclear export. by Yu-Wei Lee (432337)

“…Individual curves represent means of at least 23 cells. NGF significantly increases the FGFR1-EGFP exchange between nucleus and cytoplasm (half-time decreases) without affecting the FGFR1-EGFP mobile population. …”

Effect of the Brazilian Cardioprotective Nutritional Program on the Quality of Life of Atherosclerotic Disease Patients by Patrícia Regina Thomé Martins (14775903)

“…Waist circumference decreased in both groups over time, and low-density lipoprotein cholesterol (LDL-C) levels decreased in the IG but not in the CG after four years of follow-up. …”

Blockage of ATF-3 attenuated the inhibitory effect of U-II on DOX -induced apoptosis. by Yen-Ling Chen (636565)

“…(C) The effect of ATF-3 siRNA on U-II -decreased DOX -induced apoptosis. (D) The effect of ATF-3 siRNA on U-II -decreased DOX -induced cell viability. …”

The <i>miR-106b-93-25</i> cluster promoted EMC cell growth. by Zhi-Ning Zhao (138018)

“…<i>miR-106b</i>, <i>miR-93</i>, <i>miR-25</i> promoted the growth of ECC-1 cells, while their inhibitors significantly decreased proliferation in ECC-1 cells. Values represent the means ± SD from triplicate determinations. …”

Unraveling the Complex Trait of Harvest Index with Association Mapping in Rice (<em>Oryza sativa</em> L.) by Xiaobai Li (152726)

“…<div><p>Harvest index is a measure of success in partitioning assimilated photosynthate. …”

SFN suppressed HCV protein expression and RNA replication. by Jung-Sheng Yu (3214659)

“…<p>(A) Structures of SFN and its analogs. (B, C) HCV protein and RNA expression were decreased by SFN treatment in the HCV replicon system. …”

<i>HvHMA1</i> expression leaves is down-regulated under metal toxicity and is slightly up-regulated under Zn deficiency. by Maria Dalgaard Mikkelsen (121256)

“…<p><i>HvHMA1</i> expression under A) Zn toxicity after 24 (black) or 48 (grey) hours exposure, B) Cu toxicity after 24 (black) or 48 (grey) hours exposure and C) Cd toxicity after 24 (black) or 48 (black) hours exposure. …”

K562 cells with ABCG2 overexpression exhibited attenuated apoptosis and were no longer arrested in S phase by mitoxantone treatment. by Fang-Fang Huang (119739)

“…The histogram represented the means ± s.d. for three replicates. *<i>P</i><0.05.…”

<i>Fzr</i> mutation blocks endoreplication in PSG cells. by Wenliang Qian (639395)

“…<p>(<b>A</b>) EdU staining in silkworm PSG cells. The PSG cells of the control could be strongly stained with EdU, but no EdU signal was detected in PSG cells with <i>Fzr</i> mutation. …”

Endothelial dysfunction in the WTD-GS (+) group is independent of metabolic parameters. by Kazuma Ogiso (11993634)

“…<p>A: Body weight curve over the duration of feeding and administration. § <i>P</i> < 0.001 comparison between diet groups, two-way repeated-measures ANOVA. …”

Ethynyl deoxyuridine dose titration for labeling lateral ventricular wall cells in adult mouse brain by Hyung-song Nam (8914220)

“…<p dir="ltr">Ethynyl deoxyuridine (EdU) can be toxic to cells (<a href="https://doi.org/10.1073/pnas.1219563110" target="_blank">https://doi.org/10.1073/pnas.1219563110</a>). …”

Study on the expression of mRNA related to biofilm formation of <i>C. albicans</i> by CSR extract (100 μg/mL). by Xuxi Cheng (22453447)

“…<p><b>(A)</b> Differentially expressed genes (DEGs) analysis performed on transcriptomic samples. …”

Discovery of Novel Substituted <i>N</i>‑(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors by Jimin Xu (2208961)

“…The preliminary mechanistic studies indicated that compounds <b>6</b> and <b>43</b> possibly target the HAdV DNA replication process, while compounds <b>46</b> and <b>47</b> suppress later steps of HAdV life cycle. Notably, among these derivatives, compound <b>15</b> showed improved anti-HAdV activity (IC₅₀ = 0.27 μM), significantly decreased cytotoxicity (CC₅₀ = 156.8 μM), and low <i>in vivo</i> toxicity (maximum tolerated dose = 150 mg/kg in hamster) as compared with niclosamide, supporting its further <i>in vivo</i> efficacy studies for the treatment of HAdV infections.…”

Study design and results for iTRAQ^® protocol. by Guillaume Desoubeaux (3446336)

“…<p>A—the iTRAQ^® reagent is designed as an isobaric stable tag consisting in a charged reporter group that retains charge (N,N-dimethylpiperazine), a peptide reactive group (N-hydoxy-succinimide) that is amide-linked to the N-terminus and the ε-amino side chains of all the peptides got from prior tryptic digestion, and a neutral balance portion (carbonyl) to maintain an overall mass of 305 kDa by the means of differential isotopic enrichment with ¹³C, ¹⁵N and ¹⁸O atoms. …”

Comparison of CBVs in different brain regions of WT and Katnal2-KO mice. by Ryeonghwa Kang (6793046)

“…<p>(A) Comparisons of cerebral blood volumes (CBVs) in WT and Katnal2-KO brains, as shown by the extents of decreases in fMRI signals induced by hypoxic nitrogen stimulus in different brain regions (left, relative CBVs) and the KO values normalized to WT values (right, %WT). …”

STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I by Cefan Zhou (7302203)

“…Moreover, we observed that STYK1 directly binds to the PtdIns3K-C1 complex as a homodimer. The binding with this complex was promoted by Tyr191 phosphorylation, by means of which the kinase activity of STYK1 was elevated. …”