Schematic representation of the possible effects of PARP-1 activation on mTORC1 and mTORC2 components and cell death. by Chantal Éthier (36413)

“…PAR transiently accumulates and its metabolism results in a decrease in ATP and NAD⁺ levels, while cellular AMP increases concomitantly. …”

Comprehensive transcriptome analysis and flavonoid profiling of Ginkgo leaves reveals flavonoid content alterations in day–night cycles by Jun Ni (68173)

“…A detailed analysis of individual flavonoids showed that most of their contents were decreased by various degrees. …”

Example of the rules involved in Collagen 1 turnover. by Matthieu Bouguéon (19251466)

“…<p><b>A</b>), Decrease of collagen degradation, the value of <i>token COL</i>1_<i>remodeling</i>_<i>high</i> is decreased and that of <i>COL</i>1_<i>remodeling</i>_<i>low</i> is increased; <b>B</b>), Production of collagen by activated HSCs, the rate of application of the rule is proportional to the value of <i>counter intermediate</i>_<i>step</i>. …”

Effects of different production rates, penetrances and administration times of A3G^ΔVif on HIV growth curve. by Iraj Hosseini (184245)

“…In this case, it is seen that A3G(+) viruses reach a stable level below 10⁻¹ ng p24/ml and decrease very slowly up to the 15th day for <i>P_A3GΔVif</i> = 10². …”

A Review of Exotic Animal Disease in Great Britain and in Scotland Specifically between 1938 and 2007 by Onneile O. Peiso (212132)

“…</p> <h3>Conclusions</h3><p>The numbers of livestock and poultry farmed in GB grew over the years 1938–2007; the number of agricultural holdings decreased. An amalgamation of production on larger holdings took place from the 1940s to the 1980s. …”

Whole-Brain Analyses of the Local Gyrification Index (lGI) during Adolescence. by Daniel Klein (509727)

“…Age-dependent effects were corrected for multiple comparisons with a false discovery rate (FDR) of q at 0.005 and a smoothing of 5 mm was used. lGI-values showed the largest age-dependent effects in precentral, frontal and parietal regions (left hemisphere (effect sizes, Cohen's d): precentral cortex: d = 1.61, superior-frontal cortex: 1.83, lateral-orbitofrontal cortex: d = 1.06, superior parietal cortex: d = 1.20; right hemisphere: precentral cortex: d = 1.57, rostral-middle frontal gyrus: d = 1.79, pars triangularis: d = 1.36, inferior parietal cortex: d = 1.58).…”

Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci by Dennis J. Hazelett (517336)

“…Identification of such enhancer variants and their potential target genes represents a preliminary step in connecting risk to disease process.…”

Ketamine wash-in. by Anne S. Fleiner (20496284)

“…(ii) The change in post-burst spiking after the wash-in of 20 μM and 100 μM was not significant compared to the control (MWU test). However, the decrease in post-burst spiking was significantly larger after the wash-in of 100 μM ketamine than with 20 μM (MWU test). …”

Influence of the “Innocent” Ligands on the MLCT Excited-State Behavior of Mono(bipyridine)ruthenium(II) Complexes:  A Comparison of X-ray Structures and 77 K Luminescence Propertie... by Yuan-Jang Chen (1997017)

“…However, for (L)₄ = 5,12-<i>rac</i>-5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane, the X-ray crystal structure shows that the bpy ligand is twisted in the ground state (a result of methyl/bpy stereochemical repulsion) and the emrep amplitude at about 1500 cm^-1 is significantly larger for this structure than for the complex with (L)₄ = 1,4,8,11-tetraazacyclotetradecane, consistent with larger reorganizational energies of the bpy distortion modes in order to form a planar (bpy^-) moiety in the excited state of the former. …”

Supplemental Figure 1 by Wolfgang Stein (11859731)

“…<p><b>Supplemental Figure S1. </b>A. Time-triggered averages of MCN1 PSPs in LG. …”

Wetland Suitability and Connectivity for Trans-Saharan Migratory Waterbirds by Ronny Merken (781817)

“…By identifying optimal conservation targets to maintain overall habitat availability <i>en route</i>, we can accommodate an as yet absent functional connectivity component in larger management frameworks for migratory waterbirds, such as the Ramsar Convention and the EU Natura 2000 Network. …”

Essential role of Sema4D in estrogen-mediated vaginal apoptosis. by Takuji Ito (566032)

“…Each value represents the mean ± SEM of 5 mice. *<i>P</i><0.05, ANOVA. (B, C) Both TUNEL assays and cleaved caspase-3 immunohistochemistry with vaginal tissue sampled from sham-operated (Sham) 5-week-old WT female (Sema4D+/+) mice show that the number of apoptotic epithelial cells is significantly larger than that in samples from Sham-treated Sema4D−/− mice. …”

Video_2_Modeling Active Cell Movement With the Potts Model.AVI by Nara Guisoni (684738)

Interpretation of findings of the present study. by Rayane Brinck Teixeira (6676529)

“…This leads to cardiac maladaptation, resulting in impaired cardiac function associated with larger infarcted tissue area after acute MI. When JP4-039 is introduced after acute MI, its mitochondria-targeted ROS and electron scavenging activities result in a reduction of Mito-ROS and increased expression of mitochondrial complexes I and V. …”

Supplementary Material for: Emotional changes during Imagery Rescripting of aversive social memories in Social Anxiety Disorder: a randomized controlled trial by Seinsche R.J. (18588451)

“…Results: Relative to the control intervention, ImRs resulted in an initial increase in negative feelings from baseline to phase 1 and a following larger (phase 1 to phase 2) and more stable (phase 2 to phase 3) decrease in negative feelings/increase in positive feelings. …”

Comparative analysis of functional group effects on CO₂, CH₄, CO, and N₂ adsorption in UiO-66 and its derivatives by Prudhviraj Medikonda (20561356)

“…The selectivity of CO₂ over CH₄, CO, and N₂ showed that introducing larger and more complex functional groups caused a sudden decrease in selectivity with increasing temperature; this difference was more significant at lower temperatures and negligible at higher temperatures.…”

Statistical Analysis of Readthrough Levels for Nonsense Mutations in Mammalian Cells Reveals a Major Determinant of Response to Gentamicin by Célia Floquet (174515)

“…We demonstrated that the efficiency of readthrough after treatment is determined by the complex interplay between the stop codon and a larger sequence context. There was a strong positive correlation between basal and induced readthrough levels, and a weak negative correlation between basal readthrough level and gentamicin response (i.e. the factor of increase from basal to induced readthrough levels). …”

DataSheet_6_Optimization of universal allogeneic CAR-T cells combining CRISPR and transposon-based technologies for treatment of acute myeloid leukemia.pdf by Cristina Calviño (17004837)

“…Our optimized protocol allows one-step generation of edited CAR-T cells that show a similar phenotypic profile to non-edited CAR-T cells, with equivalent in vitro and in vivo antitumoral efficacy. …”

DataSheet_7_Optimization of universal allogeneic CAR-T cells combining CRISPR and transposon-based technologies for treatment of acute myeloid leukemia.pdf by Cristina Calviño (17004837)

“…Our optimized protocol allows one-step generation of edited CAR-T cells that show a similar phenotypic profile to non-edited CAR-T cells, with equivalent in vitro and in vivo antitumoral efficacy. …”

DataSheet_10_Optimization of universal allogeneic CAR-T cells combining CRISPR and transposon-based technologies for treatment of acute myeloid leukemia.pdf by Cristina Calviño (17004837)

“…Our optimized protocol allows one-step generation of edited CAR-T cells that show a similar phenotypic profile to non-edited CAR-T cells, with equivalent in vitro and in vivo antitumoral efficacy. …”