DataSheet1_Facing the Challenges of Developing Fair Risk Scoring Models.ZIP by Gero Szepannek (11564443)

“…Regulatory requirements as given by the Basel Committee on Banking Supervision (BCBS) or the EU data protection regulations have led to an increasing interest and research activity on understanding black box machine learning models by means of explainable machine learning. Even though this is a step into a right direction, such methods are not able to guarantee for a fair scoring as machine learning models are not necessarily unbiased and may discriminate with respect to certain subpopulations such as a particular race, gender, or sexual orientation—even if the variable itself is not used for modeling. …”

Synthesis and Characterization of the Electronic and Electrochemical Properties of Thienylenevinylene Oligomers with Multinanometer Dimensions by Isabelle Jestin (3004209)

“…Thus, the 16-mer can be charged up to the hexacationic state within a 0.60-V potential window. A plot of the potential of the various redox steps vs 1/Cn suggests full coalescence into a single-step process for the 20−22-mer. …”

Image_1_EGTA Can Inhibit Vesicular Release in the Nanodomain of Single Ca2+ Channels.JPEG by Yukihiro Nakamura (735502)

“…In proximity to a channel, the vesicular sensor is often saturated for a long voltage step, but not for a brief Ca²⁺ influx typically evoked by an action potential. …”

Transcriptional and Proteomic Analysis of the <em>Aspergillus fumigatus ΔprtT</em> Protease-Deficient Mutant by Shelly Hagag (171495)

“…Penetration of the pulmonary epithelium is a key step in the infectious process. <em>A. fumigatus</em> produces extracellular proteases to degrade the host structural barriers. …”

Single neuron preferences. by Simon Nougaret (17980269)

“…(C) Average response for each run of 3 subpopulations of neurons: all the neurons that respond to the appearance of the scene (left), and among these, neurons that prefer the first run with an increase in firing rate (center), and neurons that prefer the first run with a decrease in firing rate (right). Neural activity is aligned to the presentation of the scene (start of the Delay epoch), binned in a 200-ms window with a 25-ms step between each point, and normalized for each neuron by subtracting the mean activity and dividing by the standard deviation both calculated in a baseline period (−400 ms until the appearance of the scene). n = number of neurons. …”

SAM images showing similar regions of activation for central and off-centre viewing. by Jennifer B. Swettenham (360057)

“…The colour indicates the amplitude of the pseudo-<i>T</i> statistic (2<<i>T</i><6) with blue/purple colours representing power decreases. …”

Evolution of active membrane properties over time in iPSC-derived neurons plated on POL. by Deborah Prè (5659969)

“…<p>A) Representative traces of voltage clamp recordings showing fast inward currents followed by long-lasting outward currents in a cell at day 55, due to voltage steps in 10 mV increments (shown in the upper panel). …”

Presentation_2_Transcriptional Regulation of Stearoyl-Acyl Carrier Protein Desaturase Genes in Response to Abiotic Stresses Leads to Changes in the Unsaturated Fatty Acids Composit... by M. Luisa Hernández (60159)

“…In addition, darkness caused the down-regulation of SAD genes transcripts, together with a decrease in the UFA content of chloroplast lipids. …”

Two Glycosylation Sites in H5N1 Influenza Virus Hemagglutinin That Affect Binding Preference by Computer-Based Analysis by Wentian Chen (125316)

“…The binding of hemagglutinin (HA) on the viral surface to host sialic acid (SA) receptors is a requisite step in the infection process. Phylogenetic analysis reveals that H5N1 viruses can be divided into 10 clades based on their HA sequences, with most human IVs centered from clade 1 and clade 2.1 to clade 2.3. …”

Presentation_1_Randomized Controlled Trial of Modified Nasobiliary Fixation and Drainage Technique.PPTX by Na Mi (1592458)

“…The modified “tube-nose-ear” three-step technique was performed after surgery. The clinical efficacy of a modified nasobiliary fixation and drainage technique was evaluated and compared between the test group and the control group.…”

Presentation_1_Transcriptional Regulation of Stearoyl-Acyl Carrier Protein Desaturase Genes in Response to Abiotic Stresses Leads to Changes in the Unsaturated Fatty Acids Composit... by M. Luisa Hernández (60159)

“…In addition, darkness caused the down-regulation of SAD genes transcripts, together with a decrease in the UFA content of chloroplast lipids. …”

Species-level changes in biomass due to large mammalian herbivore exclusion. by Arjun B. Potter (6445646)

“…Biomass data suggested larger increases in <i>Desmodium trifolium</i> (DESTRI) and larger declines in <i>Digitaria</i> sp. 1 (DIGITA) than percent cover data. …”

Revealing Cooperation between Knotted Conformation and Dimerization in Protein Stabilization by Molecular Dynamics Simulations by Yan Xu (14594)

“…In addition to the knotted conformation, dimerization further improves the protein stability by restricting the α1−α5 separation, which is defined as a leading step for protein unfolding. These results provide important insights into the structure–function relationship of dimerization in knotted proteins.…”

Revealing Cooperation between Knotted Conformation and Dimerization in Protein Stabilization by Molecular Dynamics Simulations by Yan Xu (14594)

“…In addition to the knotted conformation, dimerization further improves the protein stability by restricting the α1−α5 separation, which is defined as a leading step for protein unfolding. These results provide important insights into the structure–function relationship of dimerization in knotted proteins.…”

Intermolecular Failure of L-type Ca²⁺ Channel and Ryanodine Receptor Signaling in Hypertrophy by Ming Xu (151206)

“…<div><p>Pressure overload–induced hypertrophy is a key step leading to heart failure. The Ca²⁺-induced Ca²⁺ release (CICR) process that governs cardiac contractility is defective in hypertrophy/heart failure, but the molecular mechanisms remain elusive. …”

Estimating Metabolic Fluxes Using a Maximum Network Flexibility Paradigm by Wout Megchelenbrink (523390)

“…By mapping measured flux data from central metabolism to the genome-scale models of <i>Escherichia coli</i> and <i>Saccharomyces cerevisiae</i> we show that i) indeed, most of the measured fluxes agree with a high adaptability of the network, ii) this result can be used to further reduce the space of feasible solutions iii) this reduced space improves the quantitative predictions made by FBA and contains a significantly larger fraction of the measured fluxes compared to the flux space that was reduced by a uniform sampling approach and iv) MMF can be used to select reactions in the network that contribute most to the steady-state flux space. …”

Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2. by P, Sneha

“…Molecular docking analysis revealed a decrease in interaction between the protein and ATP in all the 3 mutations, and molecular dynamic simulations of 50 ns showed a loss of stability and compactness in the mutant proteins. …”
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Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)^† by Vandana Purohit (2947848)

“…Finally, when the primer had a 3‘-OH, a fluorescence decrease with a rate equal to the rate of nucleotide incorporation was observed with both 0 and +1 position reporters. …”

<em>Bacillus anthracis</em> Interacts with Plasmin(ogen) to Evade C3b-Dependent Innate Immunity by Myung-Chul Chung (226513)

“…PLG-bound spores were capable of exhibiting anti-opsonic properties by cleaving C3b molecules <em>in vitro</em> and in rabbit bronchoalveolar lavage fluid, resulting in a decrease in macrophage phagocytosis. Our findings represent a step forward in understanding the mechanisms involved in the evasion of innate immunity by <em>B. anthracis</em> through recruitment of PLG resulting in the enhancement of anti-complement and anti-opsonization properties of the pathogen.…”

An Inducible Cell-Cell Fusion System with Integrated Ability to Measure the Efficiency and Specificity of HIV-1 Entry Inhibitors by Alon Herschhorn (198447)

“…<div><p>HIV-1 envelope glycoproteins (Envs) mediate virus entry by fusing the viral and target cell membranes, a multi-step process that represents an attractive target for inhibition. …”