Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-... by Schumacher, Austin E.

“…Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. …”
Get full text
Get full text
Get full text

Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021 by Austin, Carter

“…HIV-related deaths decreased by 39·7% (33·7–44·5), from 1·19 million (1·07–1·37) in 2010 to 718 000 (669 000–785 000) in 2021. …”
Get full text
Get full text
Get full text

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 by Khanh Bao, Tran

“…InterpretationThe leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. …”
Get full text
Get full text
Get full text

<i>ADF</i> with <i>th</i> variation. by Takayuki Niizato (162226)

“…The threshold parameter, <i>th</i>, decreases or increases 0.01 radians every 100 steps. …”

Activity Monitor Intervention to Promote Physical Activity of Physicians-In-Training: Randomized Controlled Trial by Anne N. Thorndike (581111)

“…Phase 1 was a 6-week randomized controlled trial comparing daily steps of residents assigned to an activity monitor displaying feedback about steps and energy consumed (intervention) or to a blinded monitor (control). …”

Training on the RI task reduced the intrinsic excitability of prelimbic neurons. by Scott J. Hayton (345714)

“…<p><b>A.</b> Action potentials were produced by increasing current steps (800 ms, 50 pA steps). …”

Diversity of mutational paths in the primary/promiscuous activity space. by Hector Garcia-Seisdedos (158269)

“…(B) The starting variant shows high level of both, the primary and promiscuous activities. Mutational steps are allowed if the primary activity is decreased and the promiscuous activity is maintained above a given threshold (shown as a horizontal black line).…”

Fig 1 - by Kunihiro Hasegawa (489742)

“…<p>Schematic illustrations of trials for the (A) decelerating condition and (B) accelerating condition during the pedal stepping task. …”

PoreWalker output for the bovine aquaporin-1 water channel (1j4n). by Marialuisa Pellegrini-Calace (27075)

“…D, U and S indicate conical frustums of decreasing diameter, conical frustums of increasing diameter and cylinders, respectively; (C) pore diameter profile at 3Å steps corresponding the pore shape in (B). …”

Simulations on the response of protein denaturation temperature to changes in environmental temperatures under conditions of threshold selection for kinetic stability. by M. Luisa Romero-Romero (347004)

“…However, after 5000 simulation steps, the T_ENV value is increased to 90°C and, after 15000 simulation steps, it is decreased to 70°C. …”

Evolution of cooperation over time. by Thomas Chadefaux (332782)

“…(A) We start at with 50% cooperators. (B) After only a few steps (), the number of cooperators has dramatically decreased, and only a few cooperative clusters survive. …”

HGP, gluconeogenesis (GNG), glycogenolysis (GLY) and GNG/HGP in short term fasting over 70 h. by Matthias König (156642)

“…(A) HGP decreases with increasing fasting time and reaches constant levels after around 25 h. …”

The effects of distributed delay on transcriptional signaling. by Krešimir Josić (155006)

“…<p>(A) For the simplified symmetric distribution where the delay takes values and with equal probability, the mean signaling time decreases with increasing variability in delay time, Eq. (8). …”

The Human Antiviral Factor TRIM11 Is under the Regulation of HIV-1 Vpr by Ting Yuan (293665)

“…In this study, we demonstrated that TRIM11 mainly suppressed the early steps of HIV-1 transduction, resulting in decreased reverse transcripts. …”

Numerical integration of the rate equations of the MerB reaction mechanism by Pedro Silva (532059)

“…</p> <p> </p> <p>Syntax is:</p> <p> </p> <p>HgMerB_kinetics [initial concentration of organomercurial (optional)] [number of steps with timestep tightening] [initial_timestep][pH] [type of molecule] [how many seconds of kinetic information you want] [HgMerB (or free MerB) concentration] [concentration of the Hg-removing molecules tested] [barriers in kcal.mol-1 for the 38 reaction steps] [name of output file]</p> <p> </p> <p>Type of molecule is : 1 for MerA, 2 for dithiothreitol, 3 for GSH or other monothiols</p> <p>Notes on the algorithm:</p> <p> </p> <p>A) concentrations are output whenever :</p> <p>A1) concentration of HgMerB decreases by 1%, or</p> <p>A2) concentration of product increases by 1% of initial MerB concentration, or</p> <p>A3) 10^7 integration timesteps have elapsed since the last output (or 3*10^5, if less than 10^7 integration timestpes have elapsed since the beginning of the simulation)</p> <p> </p> <p>B) Integration timestep is scaled to ensure that the concentration of every intermediate does not increase more than 10% of its previous concentration. …”

Quantitative phosphoproteomic analysis of the Sks1p signaling network in the filamentous Σ1278b genetic background. by Cole Johnson (222835)

“…<p>A) Schematic overview of major steps in the SILAC-based mass spectrometric analysis of Sks1p signaling; strain auxotrophies are indicated in the control and kinase-dead strains. …”

Dysregulation of immunological synapse formation during acute thymic atrophy. by Matthew J. Billard (227285)

“…Arrows may represent multiple steps. Plasma membranes are shown in gray. A detailed version of the original Metacore pathway is in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017940#pone.0017940.s006" target="_blank">Figure S6</a>. …”

Spatially distributed channels. by Romain Brette (157886)

“…B, Same as A, but with Na channel density linearly decreasing between 25 and 40 µm. …”

The coevolution of effort and replication, replicated and corrected by Florian Kohrt (13918527)

“…At this point the decline of effort has made low-effort novel research more attractive than low-effort replications (because publishing a novel positive result is associated with a higher payof than publishing a replication) and consequently the replication rate decreases again. …”

The NC algorithm reconstructs random and most small-world network topologies in all three dynamical regimes. by Sinisa Pajevic (267425)

“…<p>(A) Comparison in reconstruction efficacy between the FC (left) and the NC algorithm (right; , 20% noise). is plotted against the number of propagation steps. …”