N⁶-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon blac... by Bin Han (45760)

“…We found that both of m⁶A modifications of pri-miRNA-126 and its binding with DGCR8 were decreased after CB treatment, which resulted in the reduction of mature miRNA-126 accompanied by accumulation of unprocessed pri-miRNA-126. …”

Table_1_2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.DOCX by Wen-I Liao (586146)

“…</p><p>Results: 2ME significantly decreased all lung edema parameters, neutrophil infiltration, oxidative stress, proinflammatory cytokine production, lung cell apoptosis, tight junction protein disruption, and lung tissue injury in the IR-induced acute lung inflammation model. 2ME also increased the expression of the AnxA1 mRNA and protein and suppressed the activation of nuclear factor-κB (NF-κB). …”

Image_6_2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.JPEG by Wen-I Liao (586146)

“…</p><p>Results: 2ME significantly decreased all lung edema parameters, neutrophil infiltration, oxidative stress, proinflammatory cytokine production, lung cell apoptosis, tight junction protein disruption, and lung tissue injury in the IR-induced acute lung inflammation model. 2ME also increased the expression of the AnxA1 mRNA and protein and suppressed the activation of nuclear factor-κB (NF-κB). …”

Image_7_2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.JPEG by Wen-I Liao (586146)

“…</p><p>Results: 2ME significantly decreased all lung edema parameters, neutrophil infiltration, oxidative stress, proinflammatory cytokine production, lung cell apoptosis, tight junction protein disruption, and lung tissue injury in the IR-induced acute lung inflammation model. 2ME also increased the expression of the AnxA1 mRNA and protein and suppressed the activation of nuclear factor-κB (NF-κB). …”

Image_5_2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.TIF by Wen-I Liao (586146)

“…</p><p>Results: 2ME significantly decreased all lung edema parameters, neutrophil infiltration, oxidative stress, proinflammatory cytokine production, lung cell apoptosis, tight junction protein disruption, and lung tissue injury in the IR-induced acute lung inflammation model. 2ME also increased the expression of the AnxA1 mRNA and protein and suppressed the activation of nuclear factor-κB (NF-κB). …”

Image_3_2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.TIF by Wen-I Liao (586146)

“…</p><p>Results: 2ME significantly decreased all lung edema parameters, neutrophil infiltration, oxidative stress, proinflammatory cytokine production, lung cell apoptosis, tight junction protein disruption, and lung tissue injury in the IR-induced acute lung inflammation model. 2ME also increased the expression of the AnxA1 mRNA and protein and suppressed the activation of nuclear factor-κB (NF-κB). …”

Image_2_2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression.JPEG by Wen-I Liao (586146)

“…</p><p>Results: 2ME significantly decreased all lung edema parameters, neutrophil infiltration, oxidative stress, proinflammatory cytokine production, lung cell apoptosis, tight junction protein disruption, and lung tissue injury in the IR-induced acute lung inflammation model. 2ME also increased the expression of the AnxA1 mRNA and protein and suppressed the activation of nuclear factor-κB (NF-κB). …”

DataSheet_2_Immunotherapeutic Effects of Different Doses of Mycobacterium tuberculosis ag85a/b DNA Vaccine Delivered by Electroporation.pdf by Yan Liang (139654)

“…</p>Results<p>Compared with the phosphate-buffered saline (PBS) group, the CD4⁺IFN-γ⁺ T cells% in whole blood from 200 µg DNA IM group and four DNA EP groups increased significantly (P<0.05), CD8⁺IFN-γ⁺ T cells% (in 200 μg DNA EP group), CD4⁺IL-4⁺ T cells% (50 μg DNA IM group) and CD8⁺IL-4⁺ T cells% (50 μg and 100 μg DNA IM group, 100 μg and 200 μg DNA EP group) increased significantly only in a few DNA groups (P< 0.05). The CD4⁺CD25⁺ Treg cells% decreased significantly in all DNA vaccine groups (P<0.01). …”

DataSheet_1_Immunotherapeutic Effects of Different Doses of Mycobacterium tuberculosis ag85a/b DNA Vaccine Delivered by Electroporation.pdf by Yan Liang (139654)

“…</p>Results<p>Compared with the phosphate-buffered saline (PBS) group, the CD4⁺IFN-γ⁺ T cells% in whole blood from 200 µg DNA IM group and four DNA EP groups increased significantly (P<0.05), CD8⁺IFN-γ⁺ T cells% (in 200 μg DNA EP group), CD4⁺IL-4⁺ T cells% (50 μg DNA IM group) and CD8⁺IL-4⁺ T cells% (50 μg and 100 μg DNA IM group, 100 μg and 200 μg DNA EP group) increased significantly only in a few DNA groups (P< 0.05). The CD4⁺CD25⁺ Treg cells% decreased significantly in all DNA vaccine groups (P<0.01). …”

Relative abundance of (A) <i>Hypocreales</i>, (B), <i>Aspergillus</i>, (C) <i>Malasseziales</i>, and (D) Cladosporium identified in the synovial fluid of RA patients and healthy co... by Dargham Bayan Mohsen Hammad (7907630)

“…<p>Data determined by the amplification and sequencing of the ITS2 gene. (A) The relative abundance of order <i>Hypocreales</i> was increased in synovial fluid of RA patients relative to healthy control synovial fluid. …”

DataSheet_1_RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mou... by Mahmut Mijit (12283736)

“…Gene expression analysis demonstrated that Ref-1 inhibitors significantly decreased IL-8, FOSB, and c-Jun when functional RelA is present. …”

Data_Sheet_1_Non-canonical Interaction Between O-Linked N-Acetylglucosamine Transferase and miR-146a-5p Aggravates High Glucose-Induced Endothelial Inflammation.PDF by Wan-Yu Lo (444892)

“…Real time PCR analysis found that miR-146a-5p was decreased in HG- and glucosamine-stimulated HAECs. …”

Serum LRG levels in patients with DM-IP and the HC, and changes in serum LRG levels at baseline measurement and at 2, 4, and 8 weeks after the initiation of treatment. by Takaaki Ishida (525804)

“…<p>The serum LRG levels of the DM-IP patients were higher than those of the HC (A). The serum LRG levels at 2, 4, and 8 weeks after the initiation of treatment were significantly decreased in comparison with those before treatment (B). …”

C-terminal regions are required for interaction. by Erik C. Hett (244859)

“…Deletion of the C-terminal of RipA decreased the intensity of interaction and the C-terminal 25 amino acids of RipA were sufficient for interaction with PBP1. …”

Empirical Bayesian Random Censoring Threshold Model Improves Detection of Differentially Abundant Proteins by Frank Koopmans (1710484)

“…A challenge in proteomics is that many observations are missing with the probability of missingness increasing as abundance decreases. …”

Synthesis and Molecular Structure of Gold Triarylcorroles by Kolle E. Thomas (2043886)

“…A number of third-row transition-metal corroles have remained elusive as synthetic targets until now, notably osmium, platinum, and gold corroles. …”

Volcano plots of whole body, plasma and hepatic features in the blockade arm, including the RD, WDD, WDB and WDO Groups. by Kelli A. Lytle (845564)

“…The Pie Plots <b>[D]</b> represent a summary of the features that increased, decreased or did not change with diet treatment in each comparison.…”

Quantitative RT-qPCR demonstrate that Tat complex modulates expression of C5, CRLF2, APBA1, and BDNF. by Loreto Carvallo (4167607)

“…Significance was determined using a Wilcoxon signed-rank test. Error bars represent the median ± S.D.; **P < 0.01.…”

DataSheet_1_A20 Inhibits Intraocular Inflammation in Mice by Regulating the Function of CD4+T Cells and RPE Cells.docx by Jianping Hu (287208)

“…A decreased expression of A20 in CD4+T cells was noticed in active BD patients but not in VKH patients. …”

Data_Sheet_1_Adherence of Lactobacillus salivarius to HeLa Cells Promotes Changes in the Expression of the Genes Involved in Biosynthesis of Their Ligands.PDF by Carla Martín (8270910)

“…<p>The attachment of a variety of Lactobacilli to the mucosal surfaces is accomplished through the interaction of OppA, a superficial bacterial protein also involved in oligopeptide internalization, and the glycosaminoglycan moiety of the proteoglycans that form the epithelial cell glycocalyx. …”