Characteristics of microglial cells in the spinal cords of G93A mice. by Svitlana Garbuzova-Davis (81764)

“…MNC hUCB cell administrations significantly (p<0.001) decreased the number of microglia in the spinal cord of G93A mice compared to Media mice. …”

Silencing of Caspase-1 Reduced the SP-A Enhanced IL-1β Production Following Flagellin Stimulation. by Anastasia K. Ketko (491544)

“…Reduced caspase-1 (45kD band) was observed by immunoblot 48, 72 and 96 following cell transfection of caspase-1 siRNA (A). SP-A enhanced IL-1β production following flagellin stimulation which was decreased when caspase-1 activity was reduced (B, C).…”

Data Sheet 1_SIRT2-dependent CPT1A deacetylation in macrophages inhibits periodontitis.docx by Yixuan Jiang (7358318)

“…Additionally, ChIP-qPCR further confirmed the interaction between Sirtuin-2 (SIRT2)-CPT1A, thereby impacting the acetylation levels of CPT1A and decreasing CPT1A activity.…”

Supplementary Material for: VEGF-A Inhibition Ameliorates Podocyte Apoptosis via Repression of Activating Protein 1 in Diabetes by Bai X. (3629782)

“…Silencing VEGF-A decreased the level of c-fos and c-jun and bevacizumab and SP600125 treatment attenuated podocyte apoptosis. …”

Difference from baseline to 24 weeks for increasing and decreasing VW-MTR in T1-LV in patients. by Robert Zivadinov (105393)

Triptolide promotes pro-apoptotic condition in A549 and NCI-H460 cells. by Ilona Rousalova (470837)

“…<p>Triptolide treatment increased Apaf-1 mRNA expression level in both NSCLC cell lines (A and D). In parallel, caspase-9 activity was increased in both NSCLC cell lines (B and E). …”

Synopsis of progressively abnormal synaptic signaling in old A53T-SNCA striata. by Alexander Kurz (10807)

“…Postsynaptically, the upregulation of DRD1A and DRD2 and the decreased transcript levels of several DA-inducible genes suggest a progressively diminishing striatal DA response. …”

A and B, plots of <i>N vs. t</i> and <i>W vs. t</i> resulting from the numerical solution, with <i>k</i> = 1, of the equations corresponding to the networks in Figures 1A and 1B, r... by Moisés Santillán (85107)

“…<p>C and D, plots of <i>N vs. t</i> and <i>k vs. t</i> as <i>k</i> decays, for the models corresponding to the networks in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001561#pone-0001561-g001" target="_blank">Figures 1A and 1B</a>. …”

Walking path. by Saori Miyagishima (14593506)

Subjects:

Possible brain Aβ clearance mechanisms by Deng-Shun Wang (21099)

“…Increased production (like in familial AD) and/or decreased clearance (for most sporadic AD) will result in elevated brain Aβ levels and potentially trigger or accelerate the pathogenesis of AD. …”

The migratory behaviors of both Beas2B and A549 cells. by Shikun Wang (429367)

“…More Beas2B cells invaded after transfection with the pcDNA3-HA-RBP2 plasmid (<i>P</i> = 0.0011), whereas the number of invaded A549 cells significantly decreased when treated with RBP2 siRNA2 (<i>P</i> = 0.0005). …”

A model describing the functions of eEF1Bγ and eEF1A during tombusvirus replication. by Zsuzsanna Sasvari (193701)

“…<p>(A) Schematic representation of the secondary structure of the TBSV 3′ end and the RSE-gPR interaction. …”

TNFα and TGFβ1 induce EMT in A549 cells. by Atsushi Shiozaki (141857)

“…(D) The 72 h treatment with TNFα and TGFβ1 decreased expressions of E-Cadherin and Occludin, epithelial markers, and increased expressions of Vimentin, a mesenchymal marker, in A549 cells. …”

The mature form of miR-33a, miR-33a-5p downregulates the β-catenin gene. by Yi Fang (287944)

“…The β-catenin protein levels were normalized relative to β-actin in (A). (C) miR-33a-5p decreases β-catenin mRNA levels in Chang liver and HepG2 cells. …”

Increased total cell counts and pro-inflammatory cytokines in BAL fluid from SP-A -/- mice. by Anastasia K. Ketko (491544)

“…IL-1β was decreased in the lung of SP-A-/- mice 6 hours following PAK infection and no difference was observed in IL-1β between SP-A-/- and SP-A+/+ mice following <i>fliC</i> infection (B). …”

Recombinant IL-4 suppressed the stimulatory effect of PGI₂ analogs on IL-17A expression. by Weisong Zhou (165396)

“…<p>CD11c⁺ cell-containing CD4⁺CD62L⁺ cells isolated from spleens of OT II mice were activated with OVA_323–339 (1 µg/ml) and anti-CD28 (1 µg/ml) in the presence of IL-23 (10 ng/ml) and treated with iloprost, cicaprost, or respective vehicles for 4 days. (A and B) Iloprost and cicaprost decreased IL-4 production, but not IFN-γ production as determined by ELISA. …”

Effect of MDMA and HT on the a-wave and b-wave at 3 h and 24 h. by João Martins (5652628)

“…(A₂, B₂) Both MDMA and HT groups presented decreased time to peak values at 3 h time point when compared to Baseline ERG in both the a-wave and b-wave, while no significant differences were found at 24 h time point compared to Baseline ERG in all groups. *** p<0.001 MDMA group compared to Baseline ERG; ++ p<0.01, +++ p<0.001 HT group compared to Baseline ERG. …”

Human A53T α-Synuclein Causes Reversible Deficits in Mitochondrial Function and Dynamics in Primary Mouse Cortical Neurons by Li Li (14993)

“…Furthermore, we found that rapamycin, an autophagy inducer, rescued the decreased mitochondrial mobility. Taken together, these data demonstrate that A53T α-syn impairs mitochondrial function and dynamics and the deficit of mitochondrial transport is reversible, providing further understanding of the disease pathogenesis and a potential therapeutic strategy for PD.…”

Knockdown of transcription factors, SP1 and EGR1, attenuates miR-27a expression. by Bum-Yong Kang (350760)

“…HPAEC mRNA or proteins were then isolated. qRT-PCR was performed demonstrating decreases in SP1 (<b>A</b>) or EGR1 (<b>C</b>) mRNA levels following treatment with siRNA. …”

Efficient assembly of CENP-A at centromeres requires SMC2. by Alexander Samoshkin (260480)

“…<p>A) CENP-A levels are not significantly decreased in condensin-depleted cells. …”