Metformin inhibits glutaminase activity in a dose dependent manner: from 17.5% at 10 mM up to 68% at 100 mM (A) (* p<0.05). by M. Mar Díaz-Herrero (646639)

“…<p>This effect, analyzed by Dixon plot, showed competitive inhibition kinetics, with a K_i of 14.28 mM (B). In Caco2 cells, metformin 20 mM showed 24% inhibition of glutaminase activity at 72 hours compared to control cultures (p<0.05) (glutamate production was decreased from 26.85±0.74 µM to 19.9±2.05 µM; p<0.05) (C).…”

Helping as a Function of Depletion and Moral Identity for Participants High in Power. by Anne Joosten (746917)

Helping as a Function of Depletion and Moral Identity for Participants Low in Power. by Anne Joosten (746917)

A New Rotane Family:  Synthesis, Structure, Conformation, and Dynamics of [3.4]-, [4.4]-, [5.4]-, and [6.4]Rotane¹ by Lutz Fitjer (2466634)

“…The following special features were observed:  From <b>5</b> to <b>8</b>, the bond angles of the central ring increase while the bond angles at the spiro center of the spiroannelated cyclobutane rings decrease. As a consequence, the cyclobutane rings change their geometry from a regular trapezoid in <b>6</b> to a kite with the smallest angle at the spiro center in <b>7</b> and <b>8</b>. …”

A Difference Gel Electrophoresis Study on Thylakoids Isolated from Poplar Leaves Reveals a Negative Impact of Ozone Exposure on Membrane Proteins by Sacha Bohler (2186875)

“…The up-regulation of FNR would increase NAPDH production for reducing power and detoxification inside and outside of the chloroplast. Later on, FNR and a number of PS and ATPase subunits decrease in abundance. …”

A Difference Gel Electrophoresis Study on Thylakoids Isolated from Poplar Leaves Reveals a Negative Impact of Ozone Exposure on Membrane Proteins by Sacha Bohler (2186875)

“…The up-regulation of FNR would increase NAPDH production for reducing power and detoxification inside and outside of the chloroplast. Later on, FNR and a number of PS and ATPase subunits decrease in abundance. …”

Summary maps of hedonic and aversive shifts produced by GABA-A agonism and AMPA antagonism. by Alexis Faure (247166)

“…Criteria for including a site as hedonic was an increase >10 in ‘liking’ reactions and a decrease or no change in ‘disliking’ reactions. …”

Schematic diagram of the experimental design of a complex IBD mouse model. by Sun-Min Seo (13154880)

Myeloid lineage is affected by csrnp1a knockdown. by Jaime Espina (106906)

“…The <i>spi1</i> changes are accompanied by a significant decrease in proliferation (showed as the number of H3P within the <i>spi1</i> signal area) (E, F, and G). …”

The effect on plasma membrane expression of AMPA receptor subunits in hippocampal culture after presynaptic silencing with Bafilomycin (BAF). by Suleman Hussain (816864)

“…There is a slight, but significant decrease in labeling intensities after Bafilomycin treatment. …”

Influence of ghrelin treatment (0.5 μg/g BW, twice a day, intraperitoneal (ip.)) on bacterial load after cecal ligation and puncture (CLP)-induced sepsis. by Daniel Siegl (717509)

Influence of ghrelin treatment (0.5 μg/g BW, twice a day, intraperitoneal (ip.)) on inflammatory mediators after cecal ligation and puncture (CLP)-induced sepsis. by Daniel Siegl (717509)

Correlation of urinary CXCL1 level with proteinuria during follow-up period. by Yanfeng Zhao (308108)

“…<p>For patients with high baseline urinary CXCL1 levels (case 1 & case 2), the variation tendencies of urinary CXCL1 and proteinuria were almost the same (A & B). For patients with middle levels of baseline urinary CXCL1 (case 3 & case 4), although proteinuria relieved a lot, urinary CXCL1 levels just decreased a little (C & D). …”

Changes in the cell mortality and the percentages of clonal cells at different time points after PPP intervention. by Qi He (384033)

“…Cells at 0, 24, 48, 72, 96, and 168 h (7 d) after drug treatment were collected to calculate the mortality by Trypan Blue staining and smeared onto slides to detect the percentage of clonal cells using FISH. Over time, (A) the percentage of clonal cells progressively decreased. …”

Cumulative probabilities of achieving a CD4 count ≥650/μl (continuous lines) and a CD4/CD8 ratio ≥1 (dashed lines) after starting antiretroviral therapy as function of CD4 counts a... by Yusnelkis Milanés-Guisado (5774516)

Image4_Adenosine A2A Receptor: A New Neuroprotective Target in Light-Induced Retinal Degeneration.TIF by Manuel Soliño (5410001)

“…It also significantly decreased GFAP and activated caspase-3 levels as measured by WB and preserved retinal function, as treated eyes showed significantly greater amplitudes of a- and b-waves and oscillatory potentials. qRT-PCR revealed that SCH 58261 significantly decreased the expression of tumor necrosis factor-α. …”

Image1_Adenosine A2A Receptor: A New Neuroprotective Target in Light-Induced Retinal Degeneration.TIF by Manuel Soliño (5410001)

“…It also significantly decreased GFAP and activated caspase-3 levels as measured by WB and preserved retinal function, as treated eyes showed significantly greater amplitudes of a- and b-waves and oscillatory potentials. qRT-PCR revealed that SCH 58261 significantly decreased the expression of tumor necrosis factor-α. …”

Image3_Adenosine A2A Receptor: A New Neuroprotective Target in Light-Induced Retinal Degeneration.TIF by Manuel Soliño (5410001)

“…It also significantly decreased GFAP and activated caspase-3 levels as measured by WB and preserved retinal function, as treated eyes showed significantly greater amplitudes of a- and b-waves and oscillatory potentials. qRT-PCR revealed that SCH 58261 significantly decreased the expression of tumor necrosis factor-α. …”

Image2_Adenosine A2A Receptor: A New Neuroprotective Target in Light-Induced Retinal Degeneration.TIF by Manuel Soliño (5410001)

“…It also significantly decreased GFAP and activated caspase-3 levels as measured by WB and preserved retinal function, as treated eyes showed significantly greater amplitudes of a- and b-waves and oscillatory potentials. qRT-PCR revealed that SCH 58261 significantly decreased the expression of tumor necrosis factor-α. …”

Expression in the colonic crypts. by Johanne Davidsen (5485241)

“…<p>In normal crypts TCF4 is expressed at the base of the crypts [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200215#pone.0200215.ref008" target="_blank">8</a>] and as cells migrate towards the top of the crypts the expression of TCF4 decreases while expression of CDX2 increases [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200215#pone.0200215.ref017" target="_blank">17</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200215#pone.0200215.ref033" target="_blank">33</a>]. …”