Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution by Massimiliano Gaetani (241969)

“…Compared to standard approaches where curves are fitted to protein solubility data acquired at different temperatures and drug concentrations, Proteome Integral Solubility Alteration (PISA) assay increases the analysis throughput by 1 to 2 orders of magnitude for an unlimited number of factor variation points in such a scheme. The consumption of the compound and biological material decreases in PISA by the same factor. …”

Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution by Massimiliano Gaetani (241969)

“…Compared to standard approaches where curves are fitted to protein solubility data acquired at different temperatures and drug concentrations, Proteome Integral Solubility Alteration (PISA) assay increases the analysis throughput by 1 to 2 orders of magnitude for an unlimited number of factor variation points in such a scheme. The consumption of the compound and biological material decreases in PISA by the same factor. …”

Hydrogen Adsorption on Small Zeolite-Supported Rhodium Clusters. A Density Functional Study by Velina K. Markova (1688752)

“…Using a periodic density functional approach, we modeled the dissociative adsorption of hydrogen on small Rh clusters, supported inside the cavity of a faujasite-type zeolite. …”

Effect of oligomycin A on CV activity in the <i>c1-fdx</i> mutant. by Baoyin Chen (2635399)

Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution by Massimiliano Gaetani (241969)

“…Compared to standard approaches where curves are fitted to protein solubility data acquired at different temperatures and drug concentrations, Proteome Integral Solubility Alteration (PISA) assay increases the analysis throughput by 1 to 2 orders of magnitude for an unlimited number of factor variation points in such a scheme. The consumption of the compound and biological material decreases in PISA by the same factor. …”

The hybrid incompatibility proteins HMR and LHR interact in a defined HMR/LHR complex. by Andrea Lukacs (3752956)

Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution by Massimiliano Gaetani (241969)

“…Compared to standard approaches where curves are fitted to protein solubility data acquired at different temperatures and drug concentrations, Proteome Integral Solubility Alteration (PISA) assay increases the analysis throughput by 1 to 2 orders of magnitude for an unlimited number of factor variation points in such a scheme. The consumption of the compound and biological material decreases in PISA by the same factor. …”

Dose-dependent suppression mediated by PCE and QRNA fractions of TNP Ts Sup. by Krzysztof Bryniarski (731989)

“…<p><u><b>a</b></u>. Three-fold decreasing doses of TNP Ts Sup-derived PCE regressively suppresses adoptive CS responses down to a dose of 15μg per eventual recipient (Groups B and C). …”

Experiments were conducted in the operant conditioning box (A, protocols 1–6) or a home cage (B, protocol 6). by Agnieszka D. Wardak (17941139)

The mean moving angle of a shaking codend at each flow velocity and linear regression summary tested in a flume tank. by Vang Y. Nguyen (14492737)

Data_Sheet_1_Efavirenz restored NMDA receptor dysfunction and inhibited epileptic seizures in GluN2A/Grin2a mutant mice.PDF by Teng Zhao (1486717)

“…</p>Results<p>Mutant mice showed no significant change in the mRNA or protein expressions of NMDAR compared with wild type (WT) mice. Mice with GluN2A/GRIN2A-V685G mutation exhibited shorter latency to seizure, increased frequency of seizure-like events, decreased peak current and current area of NMDAR excitatory postsynaptic current, and decreased event frequency of micro-inhibitory postsynaptic current, compared to WT mice. …”

Variable importance plot. by Mariana S. Silva-Alves (3615719)

NMR-based metabolic profiling of urine, serum, fecal, and pancreatic tissue samples from the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer by Michelle J. Schmahl (5523305)

“…The goal of the research reported here was to determine if it was possible to identify metabolic biomarkers for detection of pre-cancerous pancreatic intraepithelial neoplasia (PanIN) that precede pancreatic adenocarcinoma. The transgenic Ptf1a-Cre; LSL-KrasG12D mouse strain was used as a model of pancreatic cancer progression. …”

Proposed model of PsrA regulation of PQS production in <i>P</i>. <i>aeruginosa</i>. by Greg Wells (4672462)

“…This apparently causes a shortage of the octanoyl-CoA needed for PQS synthesis and therefore PQS production greatly decreases.…”

Low and high threshold (panels a and b, respectively) of the two models calculated for several values of the ORNs sensitivity distance () in order of magnitude (OM). by Mario Pannunzi (553941)

Firing rates of PNs (as maximum activity) in response to a single synchronous triangular pulse of 50 ms duration applied to both ORN groups. by Mario Pannunzi (553941)

Firing rates of ORNs (as maximum activity) in response to a single synchronous triangular pulse of 50 ms duration applied to both ORN groups. by Mario Pannunzi (553941)

AZP-531, an unacylated ghrelin analog, improves food-related behavior in patients with Prader-Willi syndrome: A randomized placebo-controlled trial by Soraya Allas (4752756)

“…AZP-531, a first-in-class UAG analog, was shown to inhibit the orexigenic effect of AG in animals, to improve glycemic control and decrease body weight in humans. …”

Effects of clinical and environmental factors on bronchoalveolar antibody responses to <i>Pneumocystis jirovecii</i>: A prospective cohort study of HIV+ patients by Robert J. Blount (292240)

“…Prior PCP was associated with increased BALF IgA responses to Msg and current PCP was associated with decreased IgA responses. …”

Densitometry scan of X-ray film from normal-phase TLC of incorporation of [1-¹⁴C] acetate into lipid fraction from <i>S</i>. <i>aureus</i> following PYRC treatment. by Erica C. Larson (1344687)

“…Incorporation of radiolabeled [1-¹⁴C] acetate was decreased uniformly across the radiolabeled components of the extract in a dose-related fashion.…”