Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... by Michael, Brauer

“…For younger demographics (ie, those aged 0–4 years and 5–14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9–27·7]) and environmental and occupational risks (decrease of 22·0% [15·5–28·8]), coupled with a 49·4% (42·3–56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. …”
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DataSheet_1_Long-term water use efficiency and non-structural carbohydrates of dominant tree species in response to nitrogen and water additions in a warm temperate forest.pdf by Xiyan Jiang (14064921)

“…The increased precipitation showed a negative effect on specific leaf area (SLA) and a positive effect on leaf WUE of Q. variabilis, while it increased the leaf C and N content and decreased the leaf cellulose content of L. formosana. …”

Table_1_Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance.do... by Ana Miguel Cruz (9418637)

“…The increases in PKB and S6K1 phosphorylation were completely prevented by pre-incubation with broad spectrum purinergic receptor (P2R) blockers PPADs and suramin but not by P2 × 4 or P2 × 7 blockers 5-BDBD or A-438079, respectively. Moreover, ATPγS increased IL-6 yet decreased MIF release, similar to the cytokine profile produced by exercise. …”

Major Sources of Organic Matter in a Complex Coral Reef Lagoon: Identification from Isotopic Signatures (δ¹³C and δ¹⁵N) by Marine J. Briand (764565)

“…<div><p>A wide investigation was conducted into the main organic matter (OM) sources supporting coral reef trophic networks in the lagoon of New Caledonia. …”

Supplementary Material for: Long-Term Effects of Cognitive Behavioral Therapy on Sickness Absence and Cognitive Functioning in Patients with Stress-Related Disorders: Secondary Res... by figshare admin karger (2628495)

“…Hurdle negative binomial models evaluated SA and linear mixed-effects models analyzed cognitive outcomes. …”

Table3_Colchicine efficacy comparison at varying time points in the peri-operative period for coronary artery disease: a systematic review and meta-analysis of randomized controlle... by Zhi-Yang Wei (16752897)

“…Administration at different periods had no significant effect on decreasing the occurrence of MACE, but when administered postoperatively, we advise continuous administration with a total daily dose of 0.5 mg to obtain the same benefit while minimizing the drug's side effects. …”

Data_Sheet_1_Drought Tolerance of Soybean (Glycine max L. Merr.) by Improved Photosynthetic Characteristics and an Efficient Antioxidant Enzyme Activities Under a Split-Root System... by Nasir Iqbal (5541251)

“…Treatment T4 exhibited greater potential for proline accumulation than treatment T1 at 0, 1, 3, and 5 days after treatment, thus showing the severity of the water stress conditions. …”

Table2_Colchicine efficacy comparison at varying time points in the peri-operative period for coronary artery disease: a systematic review and meta-analysis of randomized controlle... by Zhi-Yang Wei (16752897)

“…Administration at different periods had no significant effect on decreasing the occurrence of MACE, but when administered postoperatively, we advise continuous administration with a total daily dose of 0.5 mg to obtain the same benefit while minimizing the drug's side effects. …”

Table1_Colchicine efficacy comparison at varying time points in the peri-operative period for coronary artery disease: a systematic review and meta-analysis of randomized controlle... by Zhi-Yang Wei (16752897)

“…Administration at different periods had no significant effect on decreasing the occurrence of MACE, but when administered postoperatively, we advise continuous administration with a total daily dose of 0.5 mg to obtain the same benefit while minimizing the drug's side effects. …”

Data_Sheet_1_Drought Tolerance of Soybean (Glycine max L. Merr.) by Improved Photosynthetic Characteristics and an Efficient Antioxidant Enzyme Activities Under a Split-Root System... by Nasir Iqbal (5541251)

“…Treatment T4 exhibited greater potential for proline accumulation than treatment T1 at 0, 1, 3, and 5 days after treatment, thus showing the severity of the water stress conditions. …”

Data_Sheet_1_Drought Tolerance of Soybean (Glycine max L. Merr.) by Improved Photosynthetic Characteristics and an Efficient Antioxidant Enzyme Activities Under a Split-Root System... by Nasir Iqbal (5541251)

“…Treatment T4 exhibited greater potential for proline accumulation than treatment T1 at 0, 1, 3, and 5 days after treatment, thus showing the severity of the water stress conditions. …”

Image2_First-in-Human, Double-Blind, Randomized, Placebo-Controlled Trial of TQ-F3083, a New Dipeptidyl Peptidase-4 Inhibitor, in Healthy Chinese Adults.TIF by Jingrui Liu (1694983)

“…The accumulation factor was 1.39 after multiple dose for 7 days. Decreased plasma exposure (84.87% decrease in C_max, 49.23% in AUC_0-t, and 47.77% in AUC_0-∞) was observed with administration after a high-fat and high-calorie standardized breakfast. …”

Image1_First-in-Human, Double-Blind, Randomized, Placebo-Controlled Trial of TQ-F3083, a New Dipeptidyl Peptidase-4 Inhibitor, in Healthy Chinese Adults.TIF by Jingrui Liu (1694983)

“…The accumulation factor was 1.39 after multiple dose for 7 days. Decreased plasma exposure (84.87% decrease in C_max, 49.23% in AUC_0-t, and 47.77% in AUC_0-∞) was observed with administration after a high-fat and high-calorie standardized breakfast. …”

Image3_First-in-Human, Double-Blind, Randomized, Placebo-Controlled Trial of TQ-F3083, a New Dipeptidyl Peptidase-4 Inhibitor, in Healthy Chinese Adults.TIF by Jingrui Liu (1694983)

“…The accumulation factor was 1.39 after multiple dose for 7 days. Decreased plasma exposure (84.87% decrease in C_max, 49.23% in AUC_0-t, and 47.77% in AUC_0-∞) was observed with administration after a high-fat and high-calorie standardized breakfast. …”

Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of <i>Helicobacter pylori</i>-induced atrophic gastritis, autoimmune atrophic gastritis and... by Bryony N. Parsons (469436)

“…<div><p>Several conditions associated with reduced gastric acid secretion confer an altered risk of developing a gastric malignancy. <i>Helicobacter pylori-</i>induced atrophic gastritis predisposes to gastric adenocarcinoma, autoimmune atrophic gastritis is a precursor of type I gastric neuroendocrine tumours, whereas proton pump inhibitor (PPI) use does not affect stomach cancer risk. …”

miR-126-5p by direct targeting of JNK-interacting protein-2 (JIP-2) plays a key role in <i>Theileria</i>-infected macrophage virulence by Malak Haidar (3691492)

“…In attenuated macrophages Grb2 levels drop resulting in less PTP1B recruitment, greater AGO2 phosphorylation, less miR-126-5p associated with AGO2 and a consequent rise in JIP-2 levels. …”

Does Ecophysiology Determine Invasion Success? A Comparison between the Invasive Boatman <i>Trichocorixa verticalis verticalis</i> and the Native <i>Sigara lateralis</i> (Hemiptera... by Cristina Coccia (392616)

“…<div><p>Background</p><p><i>Trichocorixa verticalis verticalis</i>, a native of North America, is the only alien corixid identified in Europe. …”

Duplex ddPCR for <i>IGF1</i> and <i>EPO</i> transgene elements. by Dirk A. Moser (655732)

“…<p>500 ng human gDNA were spiked with serial dilutions (1∶5; 1∶2; 1∶5; 1∶2 and 1∶5) of <i>IGF1</i>-standard (A), decreasing amounts of <i>IGF1</i> and <i>EPO</i>-standard (B), inverse amounts of <i>IGF1</i> (decreasing) and <i>EPO</i> (increasing) (C), <i>EPO</i> only (D) and <i>IGF1</i> multiplexed with ICS at ∼100 copies/reaction (E). …”

DataSheet_1_Assessment of the association between genetic factors regulating thyroid function and microvascular complications in diabetes: A two-sample Mendelian randomization stud... by Hongdian Li (13896276)

“…</p>Conclusion<p>In diabetic patients, an elevated TSH within the reference range was linked to a greater risk of DKD and decreased eGFR. Similarly, decreased FT4 and an increased FT3:FT4 ratio within the reference range were associated with increased ACR in diabetic patients. …”

Table_3_Weight loss improves β-cell function independently of dietary carbohydrate restriction in people with type 2 diabetes: A 6-week randomized controlled trial.PDF by Mads N. Thomsen (13270053)

“…</p>Conclusion<p>A moderately carbohydrate-restricted diet for 6 weeks decreased HbA_1c but did not improve β-cell function or glucose tolerance beyond the effects of weight loss when compared with a conventional diabetes diet in people with T2D.…”