Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

General conditions and periodontal parameters at follow-up in the primary analysis. by Hirofumi Mizuno (4597621)

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Blood soluble factors related to wound healing vary with the age. by María Paz Saldías (4430032)

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Middle-aged and aged serum do not induces GF proliferation. by María Paz Saldías (4430032)

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Characteristics of participants at baseline. by Hirofumi Mizuno (4597621)

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The effects of non-surgical periodontal treatment on glycemic control, oxidative stress balance and quality of life in patients with type 2 diabetes: A randomized clinical trial by Hirofumi Mizuno (4597621)

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Old rat serum present higher levels of pro-inflammatory cytokine. by María Paz Saldías (4430032)

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Young serum induces differentiation to myofibroblast with α-SMA incorporated into stress fiber. by María Paz Saldías (4430032)

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Flowchart of the study design. by Hirofumi Mizuno (4597621)

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Middle-aged and aged serum induces some senescent cells. by María Paz Saldías (4430032)

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Old rats present impaired wound healing compared to young rats. by María Paz Saldías (4430032)

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General conditions and periodontal parameters at baseline and follow-up in the sub-group analysis [moderately poor glycemic control (HbA1c; 7.0 to 10.0%)]. by Hirofumi Mizuno (4597621)

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Performance of <i>MH</i>_<i>G</i> vs. <i>H</i>_<i>G</i>. by Almiqdad Elzein (13141038)

APRIL blockade reduces glomerular monocyte/macrophage infiltration. by Yang Gyun Kim (792884)

“…<p>(A) Immunofluorescence analysis of F4/80 expression in the glomeruli of the Control Ab group (<i>left</i>) and the anti-APRIL Ab group (<i>right</i>) (original magnification, ×400). …”

L1 fracture illustration shows that a middle portion of the L1 vertebral body was removed and a vertical osteotomy was made to create defect of the L1 for the fracture model. by Chunfeng Zhao (320370)

APRIL blockade affects the abundance of Gr1⁻/CD115⁺ cells among PBMCs. by Yang Gyun Kim (792884)

“…<p>(A) The numbers of total monocytes, Gr1⁺/CD115⁺ monocytes, and Gr1⁻/CD115⁺ monocytes in peripheral blood were measured using flow cytometry. …”

Genotype distribution of the miR146a polymorphisms in AD patients stratified according to the decreased MMSE scores of cognitive decline in AD patiemts (n = 196) with two-year periods. by Lili Cui (418196)

VEGF-A knockdown via RNAi in mouse endothelial cells and cardiomyocytes in a doxycycline-regulatable fashion. by Mari Merentie (4781907)

“…In cardiomyocytes the knockdown of VEGF-A with the T-1 vector was shown to be dependent of the amount of virus (MOI) and dox exposure time and the decrease was larger at the cellular level in comparison to the secreted protein (d-e). …”

Decrease of Cav-1b expression negatively affects the IFN pathway. by Kristin A. Gabor (431769)

Scatter plot for the absolute decrease in CS rates (A) and the relative decrease in CS rates (B) from 2008 to 2016 among hospitals in Guangzhou grouped by their baseline CS rates. by Xiaoyan Xia (560153)

“…<p>A total of 112 hospitals with more than 100 live births both at baseline and in Stage 2 were included and were grouped by their baseline CS rates. …”