Annotation of Allosteric Compounds to Enhance Bioactivity Modeling for Class A GPCRs by Lindsey Burggraaff (6243110)

“…Endogenous ligands, such as hormones and neurotransmitters, bind to the orthosteric site, while synthetic ligands may bind to orthosteric or allosteric sites, which has become a focal point in drug discovery. Usually, such allosteric modulators bind to a protein noncompetitively with its endogenous ligand or substrate. …”

Annotation of Allosteric Compounds to Enhance Bioactivity Modeling for Class A GPCRs by Lindsey Burggraaff (6243110)

“…Endogenous ligands, such as hormones and neurotransmitters, bind to the orthosteric site, while synthetic ligands may bind to orthosteric or allosteric sites, which has become a focal point in drug discovery. Usually, such allosteric modulators bind to a protein noncompetitively with its endogenous ligand or substrate. …”

Cavitation-on-a-Chip Enabled Size-Specific Liposomal Drugs for Selective Pharmacokinetics and Pharmacodynamics by Han Shan (11545150)

“…Intriguingly, as the liposome size decreased to approximately 80 nm, the preferential accumulation of liposomal drugs in the liver transitioned to a predominant enrichment in the kidneys. …”

Ischemia-Related Subcellular Redistribution of Sodium Channels Enhances the Proarrhythmic Effect of Class I Antiarrhythmic Drugs: A Simulation Study by Kunichika Tsumoto (217241)

“…</p><p>Results</p><p>We found in the myofiber model that the subcellular redistribution of the Na⁺ channels under myocardial ischemia, decreasing in Na⁺ channel expression of the lateral cell membrane of each myocyte, decreased the tissue excitability, resulting in conduction slowing even without any ischemia-related electrophysiological change. …”

A flow chart of cellular phenotype switching at the intracellular scale. by Minna Qiao (836556)

A comparison of the experimental and simulated data after Lidamycin treatment. by Minna Qiao (836556)

Formulations for the three experimental diets on a dry-matter-basis. by Richard W. Brill (2337940)

Conductance of Alkanedithiol Single-Molecule Junctions: A Molecular Dynamics Study by Magnus Paulsson (2277118)

Conductance of Alkanedithiol Single-Molecule Junctions: A Molecular Dynamics Study by Magnus Paulsson (2277118)

Conductance of Alkanedithiol Single-Molecule Junctions: A Molecular Dynamics Study by Magnus Paulsson (2277118)

Conductance of Alkanedithiol Single-Molecule Junctions: A Molecular Dynamics Study by Magnus Paulsson (2277118)

Conductance of Alkanedithiol Single-Molecule Junctions: A Molecular Dynamics Study by Magnus Paulsson (2277118)

Conductance of Alkanedithiol Single-Molecule Junctions: A Molecular Dynamics Study by Magnus Paulsson (2277118)

Conductance of Alkanedithiol Single-Molecule Junctions: A Molecular Dynamics Study by Magnus Paulsson (2277118)

Conductance of Alkanedithiol Single-Molecule Junctions: A Molecular Dynamics Study by Magnus Paulsson (2277118)

Transcription of the Y-linked gigantic genes attenuates upon RNAi-mediated knockdown of <i>U2af38</i> and <i>SRPK</i>. by Jaclyn M. Fingerhut (6685103)

“…<p>(<b>A</b> and <b>B</b>) Coverage plots of <i>kl-3</i> (<b>A</b>) and <i>kl-2</i> (<b>B</b>) showing the normalized read depth along the gene span (exons only) in the indicated genotypes. …”

Table 1_Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors.doc... by Yiping Cao (1229856)

“…Introduction<p>The paraventricular thalamic nucleus (PVT) is recognized for its critical role in pain regulation, yet the precise molecular mechanisms involved remain poorly understood. Here, we demonstrated an essential role of the microglial adenosine A_2A receptor (A_2AR) in the PVT in regulating pain sensation and non-opioid analgesia.…”

Image 1_Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors.tif by Yiping Cao (1229856)

“…Introduction<p>The paraventricular thalamic nucleus (PVT) is recognized for its critical role in pain regulation, yet the precise molecular mechanisms involved remain poorly understood. Here, we demonstrated an essential role of the microglial adenosine A_2A receptor (A_2AR) in the PVT in regulating pain sensation and non-opioid analgesia.…”

Image 2_Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors.tif by Yiping Cao (1229856)

“…Introduction<p>The paraventricular thalamic nucleus (PVT) is recognized for its critical role in pain regulation, yet the precise molecular mechanisms involved remain poorly understood. Here, we demonstrated an essential role of the microglial adenosine A_2A receptor (A_2AR) in the PVT in regulating pain sensation and non-opioid analgesia.…”

Supplementary Material for: Regulation of IgA Class Switch Recombination in Immunoglobulin A Nephropathy: Retinoic Acid Signaling and BATF by He L. (3215133)

“…RAR alpha (RARα) or BATF siRNA decreases IgA expression. We also built IgAN rat models and found that RARα, BATF and activation-induced cytidine deaminase were upregulated in the peripheral blood, spleen and BM. …”